Navigation Links
Study Finds Parkinson’s Cell Death Blocked by Stopping Inflammatory Facto

ve cells in an area of the brain called the substantia nigra. By the time serious symptoms appear, more than 80 percent of the dopamine-producing nerve cells are already dead, and the damage is irreversible.

In addition to its beneficial role, TNF has been a suspected player in Parkinson’s because elevated levels of it are found in post-mortem brains and cerebrospinal fluid of people with the disease. A previous study by other researchers found that non-steroidal anti-inflammatory drugs that block production of TNF and related molecules can reduce the risk of developing Parkinson’s by 46 percent.

In the current study, UT Southwestern researchers injected two different substances into the rats’ brains to cause cell death in the substantia nigra – low-dose infusion of LPS, a toxin from bacteria often used to mimic chronic inflammation of the central nervous system, and 6-hydroxydopamine, which kills cells by creating an overwhelming amount of reactive oxygen and nitrogen molecules. Cell death was measured by counting neurons in stained brain slices.

When an experimental TNF inhibitor called XENP345, designed specifically to block soluble TNF, was also introduced into the brain, dopamine neuron death was reduced by about half.

The same effect was found on cultured dopamine neurons exposed to either toxin.

The researchers are now looking into why TNF inhibition did not fully protect against cell death. For example, the drug may not have been able to fully diffuse throughout the tissue, it might take longer to work than the weeks allowed in the experiment, or dopamine neuron loss might also involve processes independent of TNF.

“If an intervention could still reduce the extent or rate of cell death by 50 percent, it could make a huge difference in the life of a Parkinson’s disease patient,” Dr. Tansey said.



Sorce-Newswise
SRM
'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
(Date:8/21/2014)... Living in a quality residential community means ... with it. A quality Home Owners Association like the ... available. , Simpson Mill Plantation, ... Association Management, LLC made a recent investment in a ... an additional amenity for their neighborhood. , Situated near ...
(Date:8/21/2014)... 21, 2014 Recently, Van Uden ... patients. Alternative medicine is on the rise and ... According to The Fiscal Times, young people are ... conventional medicine. , The Fiscal Times published an ... are embracing alternative medicine. The article can be ...
(Date:8/21/2014)... the coronary arteries of chronic kidney disease patients may ... to a new study in the Journal of ... Researchers at the Johns Hopkins Bloomberg School of Public ... used measures of subclinical atherosclerosis in predicting the risk ... Approximately 50 percent of all patients with chronic kidney ...
(Date:8/21/2014)... cancer appear to have better survival if they ... Author: Uchechukwu C. Megwalu, M.D., M.P.H., of the ... York, and colleagues. , Background: Approximately 11,000 to ... year and squamous cell carcinoma accounts for the ... total surgical removal of the larynx with postoperative ...
(Date:8/21/2014)... Improv performers from Fun House Theatre and Film ... Turtle Creek memory care community in Dallas. The Unicorn ... ages 10 to 16, delivers a groundbreaking and fun-filled ... troupe's philosophy is that improv is based on relationships, ... audiences regardless of their circumstance — including bringing joy ...
Breaking Medicine News(10 mins):Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Van Uden Center Sees Growth in Alternative Medicine 2Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Surgery associated with better survival for patients with advanced laryngeal cancer 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2
... Cant smell the roses? Maybe youre depressed. Smell too ... same problem. Scientists from Tel Aviv University recently linked ... glands. It might explain why some women, without realizing ... that supports this theory was published this year in ...
... developed a novel anti-tumor compound that represents a distinct strategy: ... cells. , The results of research on the compound in ... The article is highlighted on the cover. , The compound ... solid tumors in 2007. , The idea behind the intercept ...
... Study supports hormone therapy with radiation, finding no raised ... -- New research suggests that a common but controversial ... greatly boosting patients, risk of heart problems, as some ... cases of prostate cancer, a combination of testosterone-lowering drugs ...
... a Fresh, New Look, SAN JOSE, Calif., Jan. ... ) today announced the launch of a striking,new corporate ... logo. The,new logo elevates the profile of visionary JMSR ... that has worked with numerous national industry,brands., "When ...
... Fitness Professionals Predict Fun Focused Fitness, SAN ... Exercise,(ACE) has completed its annual survey of its ... advanced health and fitness,specialists and lifestyle and weight ... fitness industry. 2008 promises to be filled with,water ...
... 3 MedCath Corporation,(Nasdaq: MDTH ) announced that ... Annual JPMorgan Healthcare Conference held January,7 - 10, 2008 ... MedCath,s senior management will give its presentation on ... presentation will be,webcast live over the Internet via MedCath,s ...
Cached Medicine News:Health News:Why some depressed girls can't smell the roses 2Health News:Novel anticancer strategy moves from laboratory to clinic 2Health News:Novel anticancer strategy moves from laboratory to clinic 3Health News:Combo Therapy Cuts Prostate Cancer Death Rates 2Health News:Combo Therapy Cuts Prostate Cancer Death Rates 3Health News:Jan Marini Skin Research Gives Familiar Logo a Facelift 2Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 2Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 3Health News:American Council On Exercise (ACE) 2008 Fitness Trend Predictions 4
(Date:8/20/2014)... The National Association of Drug Diversion ... by the real-time, pseudoephedrine (PSE) blocking system in ... Exchange (NPLEx), automatically blocks unlawful pseudoephedrine sales and ... and make arrests. Data released by NPLEx shows ... blocked the sale of more than 7,481 boxes of ...
(Date:8/20/2014)... LUTHERVILLE, Md. , Aug. 20, 2014 /PRNewswire/ ... today lauded the latest results achieved by the ... known as the National Precursor Log Exchange (NPLEx), ... enforcement officials track down methamphetamine offenders and make ... in Michigan blocked the ...
(Date:8/20/2014)... , Aug. 20, 2014 ... research report is available in its ... Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html Given the ... (HAIs), demand has increased for solutions ...
Breaking Medicine Technology:Kansas's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Michigan's Stop-Sale System Achieves Significant Results In Battle Against Meth 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6
... MedNet Solutions, a global life sciences technology solutions ... pleased to announce that iMedNet™ EDC , ... solution, is now commercially available.   ... and easy-to-use web-based solution that allows non-technical research ...
... 2011 Reportlinker.com announces that a new market research ... Top 200 Biopharmaceuticals Industry Report (Global) ... Biopharmaceuticals Industry Report Plimsoll Publishing Ltd. ... the Global Biopharmaceuticals Industry. Using the unique Plimsoll method ...
Cached Medicine Technology:MedNet Solutions Announces the Release of iMedNet EDC 2Reportlinker Adds Top 200 Biopharmaceuticals Industry Report (Global) 2Reportlinker Adds Top 200 Biopharmaceuticals Industry Report (Global) 3Reportlinker Adds Top 200 Biopharmaceuticals Industry Report (Global) 4
BioSoft alcohol gel hand antiseptic with soothing moisturizers is a fast-acting, broad-spectrum antimicrobial solution. BioSoft alcohol gel hand antiseptic applies easily, requires no rinsing and dri...
... Scrub Care povidone-iodine (PVP-I) antimicrobial solutions ... control in all hospital and health-care settings. ... gel have a broad spectrum of activity, ... bacteria that may cause infection. The new ...
... hand sanitizers like Aplicare No Rinse Isopropyl ... as the recommended product for hand disinfection ... Guidelines for hand hygiene., According to the ... be prevented with better infection control programs. ...
This is long known for its purity and mildness, Castile Soap is also an effective cleaning agent that is used in a variety of applications. It rinses clean while leaving the skin soft and healthy....
Medicine Products: