Navigation Links
Study Finds No Survival Benefit for Gastric Cancer Patients

A more intensive postoperative chemotherapy regimen for high-risk gastric cancer patients did not improve their survival,// according to a randomized controlled trial in the April 18 Journal of the National Cancer Institute.

The five-year survival rate for gastric cancer patients who undergo radical surgery is typically between 15 and 32 percent. Efforts to improve survival with new therapies, including postoperative chemotherapy, have yet to yield statistically significant results.

Stefano Cascinu, M.D, of the Universita Politecnica delle Marche in Ancona, Italy, and colleagues conducted a multi-center, randomized phase III trial of 397 high-risk gastric cancer patients who were given either eight weekly treatments of five chemotherapy drugs or six monthly treatments of only two of the drugs. After their treatment, the patients were followed for a median of 54 months.

The researchers found no significant difference in survival between the two groups. The five-drug regimen did not reduce the risk of death or relapse. Both groups had about a 50 percent five-year survival rate, which is much higher than previous studies have shown.

"The unexpectedly long survival time in our trial may be due to several factors, among them, the high quality of surgery…observed in our trial," the authors write. "Furthermore, toxicity associated with postoperative chemotherapy as reported in our trial and in other studies…suggest that it may be preferable to move toward preoperative approaches."

In an accompanying editorial, Susan Ellenberg, Ph.D., and Weijing Sun, M.D., of the University of Pennsylvania School of Medicine in Philadelphia, discuss the lessons to be learned from this negative result. "Unfortunately, some legislators, pushed by patient advocacy groups, seem willing to ignore the lessons of the past and are pushing for an extensive rollback of regulatory policy such that drugs for cancer and other life-threatening diseases could be marketed without being shown to be beneficial in a rigorously designed and conducted trial such as this study's authors have described. This trial provides an important reminder of how much patients have to lose should such efforts prevail," the authors write.

Source-Eurekalert/
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about ... intend to develop to enable prevention of a major side effect of chemotherapy ... especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Calif. , Oct. 11, 2017  BioPharmX Corporation ... scientific team that developed an innovative way to use ... of the delivery of new drugs. ... Fall Clinical Dermatology Conference will show how researchers from ... Hospital, Harvard Medical School used a suite of imaging ...
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology: