Navigation Links
Study Finds No Survival Benefit for Gastric Cancer Patients

A more intensive postoperative chemotherapy regimen for high-risk gastric cancer patients did not improve their survival,// according to a randomized controlled trial in the April 18 Journal of the National Cancer Institute.

The five-year survival rate for gastric cancer patients who undergo radical surgery is typically between 15 and 32 percent. Efforts to improve survival with new therapies, including postoperative chemotherapy, have yet to yield statistically significant results.

Stefano Cascinu, M.D, of the Universita Politecnica delle Marche in Ancona, Italy, and colleagues conducted a multi-center, randomized phase III trial of 397 high-risk gastric cancer patients who were given either eight weekly treatments of five chemotherapy drugs or six monthly treatments of only two of the drugs. After their treatment, the patients were followed for a median of 54 months.

The researchers found no significant difference in survival between the two groups. The five-drug regimen did not reduce the risk of death or relapse. Both groups had about a 50 percent five-year survival rate, which is much higher than previous studies have shown.

"The unexpectedly long survival time in our trial may be due to several factors, among them, the high quality of surgery…observed in our trial," the authors write. "Furthermore, toxicity associated with postoperative chemotherapy as reported in our trial and in other studies…suggest that it may be preferable to move toward preoperative approaches."

In an accompanying editorial, Susan Ellenberg, Ph.D., and Weijing Sun, M.D., of the University of Pennsylvania School of Medicine in Philadelphia, discuss the lessons to be learned from this negative result. "Unfortunately, some legislators, pushed by patient advocacy groups, seem willing to ignore the lessons of the past and are pushing for an extensive rollback of regulatory policy such that drugs for cancer and other life-threatening diseases could be marketed without being shown to be beneficial in a rigorously designed and conducted trial such as this study's authors have described. This trial provides an important reminder of how much patients have to lose should such efforts prevail," the authors write.


Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:

(Date:11/24/2015)... ... November 24, 2015 , ... ... their knowledge and experiences at a live taping of the next CURE ... the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & Conference ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... With Thanksgiving ... Insurance is sharing safety tips to help protect your family and vehicle. , According ... around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips from ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... Cleveland University-Kansas City (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester ... University President Carl S. Cleveland III on October 16. , “Katie is very ...
(Date:11/24/2015)... , ... November 24, 2015 , ... Bibliomotion ... and Detroit Taught Me about Reinvention and Diversity by Nancy M. Schlichting, ... suffer, with hospitals failing to adequately address the needs of patients and their families, ...
(Date:11/24/2015)... , ... November 24, 2015 , ... All her life, Don Peck’s mother wondered if ... obituary said she might have been. After a 25-year search for information, Don and ... whom she shared a last name. Turns out, it was Don’s father who was ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 25, 2015 WuXi PharmaTech (Cayman) ... a leading open-access R&D capability and technology platform company ... operations in China and ... at an extraordinary general meeting of shareholders held today, ... to authorize and approve the previously announced agreement and ...
(Date:11/24/2015)... , Nov. 24, 2015  Natera, ... in non-invasive genetic testing and the analysis ... it will present at the 27 th ... December 2, 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, Ph.D., ... financial results, business activities and financial outlook. ...
(Date:11/24/2015)... 24, 2015  In the pharmaceutical industry, companies want ... to quickly uncover new insights, tactics and strategies that ... --> However, organizations often find it ... and ensure that all rules and regulations are met ... major barrier to efficiently launching market research projects is ...
Breaking Medicine Technology: