Navigation Links
Study Finds No Survival Benefit for Gastric Cancer Patients

A more intensive postoperative chemotherapy regimen for high-risk gastric cancer patients did not improve their survival,// according to a randomized controlled trial in the April 18 Journal of the National Cancer Institute.

The five-year survival rate for gastric cancer patients who undergo radical surgery is typically between 15 and 32 percent. Efforts to improve survival with new therapies, including postoperative chemotherapy, have yet to yield statistically significant results.

Stefano Cascinu, M.D, of the Universita Politecnica delle Marche in Ancona, Italy, and colleagues conducted a multi-center, randomized phase III trial of 397 high-risk gastric cancer patients who were given either eight weekly treatments of five chemotherapy drugs or six monthly treatments of only two of the drugs. After their treatment, the patients were followed for a median of 54 months.

The researchers found no significant difference in survival between the two groups. The five-drug regimen did not reduce the risk of death or relapse. Both groups had about a 50 percent five-year survival rate, which is much higher than previous studies have shown.

"The unexpectedly long survival time in our trial may be due to several factors, among them, the high quality of surgery…observed in our trial," the authors write. "Furthermore, toxicity associated with postoperative chemotherapy as reported in our trial and in other studies…suggest that it may be preferable to move toward preoperative approaches."

In an accompanying editorial, Susan Ellenberg, Ph.D., and Weijing Sun, M.D., of the University of Pennsylvania School of Medicine in Philadelphia, discuss the lessons to be learned from this negative result. "Unfortunately, some legislators, pushed by patient advocacy groups, seem willing to ignore the lessons of the past and are pushing for an extensive rollback of regulatory policy such that drugs for cancer and other life-threatening diseases could be marketed without being shown to be beneficial in a rigorously designed and conducted trial such as this study's authors have described. This trial provides an important reminder of how much patients have to lose should such efforts prevail," the authors write.

Source-Eurekalert/
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... Dallas, TX (PRWEB) , ... December 07, 2016 ... ... service based in Dallas, Texas, is condemning "scam operations" carried out by unethical ... to bring these scam operations to a halt. According to Texas Premier Locksmith, ...
(Date:12/7/2016)... Aliso Viejo, California (PRWEB) , ... December 07, 2016 , ... ... placed above any and all media," said Christina Austin - CEO of Pixel Film ... of logo with easy to use drop zones. Editors can select from a variety ...
(Date:12/7/2016)... ... 2016 , ... Maureen McLaughlin, LA.c., a certified acupuncturist, is ... Connecticut (RMACT). McLaughlin brings nearly 20 years of experience with fertility patients to ... their family building goals. Acupuncture helps fertility patients by supporting the ...
(Date:12/7/2016)... , ... December 07, 2016 , ... “Walking With God: ... stories that will inspire the reader to be aware of God's direction in their ... published author, Sanford Smith, retired teacher and active church leader. , Sanford ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Business Architecture Guild ... Reston, VA on March 21-22, 2017. This premier event features business practitioners and ... a cross-section of industries such as financial services, insurance, healthcare, manufacturing, transportation, retail, ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 2016  "Blood Tests replace Surgical Biopsies. Single ... The Diagnostic, Monitoring and Screening Test opportunities are ... occurring using in vitro blood testing to identify ... backing, has announced a single blood test to ... than the market. New technology that definitively identifies ...
(Date:12/6/2016)... Anaplastic Oligoastrocytoma - Pipeline Review, H2 ... Pharmaceutical and Healthcare disease pipeline guide Anaplastic Oligoastrocytoma ... of the Anaplastic Oligoastrocytoma (Oncology) pipeline landscape. ... when two types of cells in the brain, ... to form a mass. These brain cells are ...
(Date:12/6/2016)... LOUISVILLE, Ky. , Dec. 6, 2016 /PRNewswire/ ... notice of accreditation from the College of American ... Improvement Amendments (CLIA) for its new laboratory in ... company recently moved its North American headquarters. ... offers Sanger sequencing -- which is still considered ...
Breaking Medicine Technology: