Navigation Links
Study Finds No Survival Benefit for Gastric Cancer Patients

A more intensive postoperative chemotherapy regimen for high-risk gastric cancer patients did not improve their survival,// according to a randomized controlled trial in the April 18 Journal of the National Cancer Institute.

The five-year survival rate for gastric cancer patients who undergo radical surgery is typically between 15 and 32 percent. Efforts to improve survival with new therapies, including postoperative chemotherapy, have yet to yield statistically significant results.

Stefano Cascinu, M.D, of the Universita Politecnica delle Marche in Ancona, Italy, and colleagues conducted a multi-center, randomized phase III trial of 397 high-risk gastric cancer patients who were given either eight weekly treatments of five chemotherapy drugs or six monthly treatments of only two of the drugs. After their treatment, the patients were followed for a median of 54 months.

The researchers found no significant difference in survival between the two groups. The five-drug regimen did not reduce the risk of death or relapse. Both groups had about a 50 percent five-year survival rate, which is much higher than previous studies have shown.

"The unexpectedly long survival time in our trial may be due to several factors, among them, the high quality of surgery…observed in our trial," the authors write. "Furthermore, toxicity associated with postoperative chemotherapy as reported in our trial and in other studies…suggest that it may be preferable to move toward preoperative approaches."

In an accompanying editorial, Susan Ellenberg, Ph.D., and Weijing Sun, M.D., of the University of Pennsylvania School of Medicine in Philadelphia, discuss the lessons to be learned from this negative result. "Unfortunately, some legislators, pushed by patient advocacy groups, seem willing to ignore the lessons of the past and are pushing for an extensive rollback of regulatory policy such that drugs for cancer and other life-threatening diseases could be marketed without being shown to be beneficial in a rigorously designed and conducted trial such as this study's authors have described. This trial provides an important reminder of how much patients have to lose should such efforts prevail," the authors write.

Source-Eurekalert/
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... GrassrootsHealth published ... rate of type 2 diabetes in the GrassrootsHealth cohort with substantially higher vitamin ... a change in public health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Guruji Mahendra ... 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... happiness. Mahendra Trivedi is known by over 250,000 people from over 40 different ...
(Date:2/7/2016)... ... February 07, 2016 , ... Women's Excellence staff, in all four locations, wore ... Wear Red Day is the first Friday each February and a day to bring ... in 3 deaths among women each year – more than all cancers combined. Go ...
(Date:2/6/2016)... San Rafael, CA (PRWEB) , ... February 06, 2016 , ... ... 2016 Youth Ultimate Coaching Conference (YUCC) . This event brings together top non-profit leaders, ... is “Gender Equity and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of ...
(Date:2/5/2016)... ... February 05, 2016 , ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran ... it started in 2003. This year, he ran all 26.2 miles with a green ... team the Miami Heat. , This Sunday, while many are watching the Superbowl, Steven ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)...   GS1 US will hold a series ... GS1 Standards implementation to address the requirements of the ... (UDI) rule. Scott Brown , director ... senior director industry development, medical devices, GS1 US; and ... --> Scott Brown , director ...
(Date:2/8/2016)... NORRITON, Pa. , Feb. 8, 2016 /PRNewswire/ ... of November Research Group (NRG),s pharmacovigilance technology ... pharmacovigilance system-related consulting services and an Oracle Argus ... compliance services to Life Sciences companies. ... strengthens and expands HighPoint,s life sciences capabilities and ...
(Date:2/8/2016)... PALO ALTO, Calif. , Feb. 8, 2016 ... chemical manufacturing, and Kodiak Sciences Inc., a biopharmaceutical company ... retinal disease, announced today agreements for the clinical supply ... manufacture material at multiple sites, including Slough (UK), Visp ... --> Retinal diseases, such as age-related ...
Breaking Medicine Technology: