Navigation Links
Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model

A just-published research study by Dr. R Preston Mason and colleagues at Elucida Research has determined that astaxanthin, a relatively //unknown carotenoid found in nature, shows significant promise as a viable scaffold for a new therapy to treat cardiovascular disease based on its exceptional antioxidant properties in membrane models.

Combined with published proof-of-concept, pre-clinical and anecdotal human data, the results of the Mason study (Differential effects of carotenoids on lipid peroxidation due to membrane interactions; xray diffraction analysis by McNulty et al.) signify that astaxanthin exhibits potential utility for use as the scaffold for antioxidant/anti-inflammatory agents in the treatment of cardiovascular and other chronic inflammatory diseases. An astaxanthin derivative may improve, or augment, the restoration of the cellular oxidation balance (i.e. redox status) of mitochondria and cell signaling pathways upstream from the point that produces activation of bioactive inflammatory mediators.

"These data clearly demonstrate a differentiation within the carotenoid class of medically promising antioxidants and provided, in part, the impetus for Cardax Pharmaceuticals to advance an astaxanthin-based derivative into an IND development program,” according to Fredric Pashkow, Executive Vice President and Chief Medical Officer of the Company and former head of U.S. Medical Affairs for cardiovascular drugs at Sanofi-Aventis.

Pashkow also said that the work from Mason’s lab suggests astaxanthin could provide a platform for discovery of an entirely new class of safe, cardiovascular drugs. “These potent antioxidants may be the third big wave in the modern therapy for the secondary prevention of heart attack and stroke. In the heart, these agents probably will work by recalibrating the cellular oxidation balance in order to blunt the cell and tissue inflammatory response to injury and limit damage to the myocardium.”

In addition, by limiting the amount of oxidative damage to LDL, the “bad cholesterol,” an astaxanthin derivative could alter the progress of atherosclerosis, the underlying inflammatory process that clogs arteries and is responsible for most heart attacks and strokes when an atherosclerotic plaque ruptures.

Pashkow maintains that statins represented the “first big wave” of cardiovascular preventive therapy. They proved to lower the risk of a second heart attack or cardiovascular death by 45% over 5 years, though more than half of the people treated did not realize their benefit. Increasing the dose of the statin improves the outcome and extends the benefits to people who have risk factors alone such as high cholesterol, but dose limiting side effects emerge especially when the drugs are taken for a long time. Pashkow said that the recent problems encountered with Pfizer’s torcetrapib highlight the impact of a late stage pipeline non-approval combined with the looming patent expiry of the current market leading therapy.

Antiplatelet therapies, particularly aspirin and aspirin in combination with other antiplatelet agents represent the “second big wave” of preventive therapies following a heart attack. In combination, they reduce the risk of future heart attacks and strokes by about 30% over a one-year period.

However, an appreciable segment of the population are 'resistant' to antiplatelet therapy and remain relatively unprotected. More potent antiplatelet therapies, or increased doses of aspirin increase the risk of bleeding. “This wave of treatments,” said Pashkow “may be peaking as well.”

Cardax Pharmaceuticals is exploring the use of astaxanthin and novel astaxanthin derivatives, as well as other carotenoids, for use as medical therapeutics (i.e. antioxidant/anti-inflammatory) in disease states characterized by abnormal cellular oxidation and chronic inflammation (e.g. cardiovascular, liver, ocular, prostatic and neurodegenerative diseases).

Source-Nwswise
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... , ... January 20, 2017 , ... Source Vitál Apothecary, ... 100 percent pure essential oils, announced the company had a successful visit to the ... annual ECRM event gives companies that work in the nutritional, sports and health industries ...
(Date:1/20/2017)... ... January 20, 2017 , ... ATP Science, ... everyday lives, recently attended the January ECRM Trade Show in Hilton Head, SC, ... for its large range of supplements that keep the body functioning at its ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... sugar-free alternative VW+ 002. The drinks have been produced in collaboration with Zlatan ... perform during your workout. , After a successful launch in Sweden last year, ...
(Date:1/20/2017)... ... , ... “I Forgive You”: a fine examination of how God handles sin, including how ... published author, Stephen Miller, who, for over ten long years has been waiting to release ... Trinidad and Tobago, he has been serving the Lord for over twenty years, and he ...
(Date:1/20/2017)... ... ... “Knowledge is God’s Lighthouse”: a moving and colorful collection of prayers that reminds ... published author, Gene Gaapf, a retired truck driver, and a long-time writer, whose published ... high school and have many different titles,” Gaapf mentions about his different works. “I ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017  Abaxis, Inc. (NasdaqGS: ABAX ... instruments and consumables for the medical and veterinary markets ... financial results for the third quarter fiscal year 2017, ... 4:15 p.m. ET on Thursday, January 26, 2017.  The ... fiscal year 2017 after the market closes on Thursday, ...
(Date:1/19/2017)...   Science Exchange , the leading marketplace ... the first five replication studies from the ... in eLife today. Despite intense scrutiny around reproducibility ... evaluation of reproducibility rates that may identify specific ... assessments of reproducibility, the results of this project ...
(Date:1/19/2017)... , January 18, 2017 , , Marks E-QURE ... distribution agreement, following similar agreements in ... Wound care is $2 5 ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment ... - Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia for ...
Breaking Medicine Technology: