Navigation Links
Study Finds Abdominal Fat Not the Prime Cause for Metabolic Syndrome

Researchers have found that abdominal fat is not the primary factor for causing metabolic syndrome but insulin resistance also plays a part in leading to a cluster of conditions that includes the most dangerous heart attack risk factors including pre-diabetes, diabetes, high blood pressure, and changes in cholesterol.

Abdominal fat or the spare tire that many of us carry has long been linked to metabolic syndrome, a combination of medical disorders that increase one's risk for cardiovascular disease and diabetes.

However, the study conducted by a team of researchers led by Gerald I. Shulman and Kitt Falk Petersen at Howard Hughes Medical Institute (HHMI), Yale University School of Medicin, found otherwise.

Insulin resistance is a condition in which the body's cells become resistant to insulin, a hormone secreted by the pancreas that plays an essential role in regulating the carbohydrates, lipids, and proteins obtained from food.

As part of the study, researchers used powerful new magnetic resonance imaging techniques to observe how nutrients are channelled in the body in both insulin resistant and insulin sensitive human subjects which included young, lean, non-smoking, healthy people who were sedentary and matched for physical activity.

The volunteers had no confounding factors typically associated with obesity and type 2 diabetes, which have been thought to play a key role in the pathogenesis of the metabolic syndrome, apart from insulin resistance in one cohort.

Researchers provided the volunteers with two meals high in carbohydrates, and turned to magnetic resonance spectroscopy to measure the production of liver and muscle triglyceride, the storage form of fat, glycogen, and carbohydrate.

The study found that in the insulin resistant subjects, the energy obtained from their carbohydrate rich meals was rerouted to liver triglyceride production, elevating triglyceri des in the blood by as much as 60 percent and lowering HDL cholesterol, the good cholesterol by 20 percent.

"What we found is that (insulin) sensitive individuals took the energy from carbohydrate in the meals and stored it away as glycogen in both liver and muscle," Shulman said.

"In contrast to the young, lean, insulin-sensitive subjects, who stored most of their ingested energy as liver and muscle glycogen, the young, lean, insulin-resistant subjects had a marked defect in muscle glycogen synthesis and diverted much more of their ingested carbohydrate into liver fat production, the researchers said.

The study demonstrated that insulin resistance in skeletal muscle, caused by decreased ability of muscle to make glycogen, the stored form of carbohydrate from food energy, can promote an elevated pattern of lipids or fats in the bloodstream that underpins the metabolic syndrome.

Researchers also found that skeletal muscle insulin resistance preceded the development of insulin resistance in liver cells, and that fat production in the liver was increased.

The findings of the study were published in the July issue of the Proceedings of the National Academy of Sciences (PNAS).


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and ... to shed lights on the variety of topics detailing why we appreciate nurses in ... why this career has gone from being in a major recession to one of ...
(Date:5/27/2016)... ... , ... Beleza Medspa has initiated a new program to assist ... first time that Coolsculpting is being used for for more than just cosmetic purposes. ... meet the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test ...
(Date:5/26/2016)... ... May 26, 2016 , ... Despite last week’s media reports hinting ... and company to wait until March 2017 for an interest rate increase, according to ... College of Business. , “The Federal Open Market Committee (FOMC) dot charts are of ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University ... specialty academic programs. , Answering to the increasing demand for curricular specializations, the ... law, and environmental and land use law. ,  , “The demand for lawyers ...
(Date:5/26/2016)... ... 2016 , ... There are nearly 14.5 million people living with and beyond ... Sunday, June 5, 2016, communities around the world will gather to recognize these cancer ... Cancer Survivors Day® is an annual worldwide Celebration of Life that is held on ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... India , May 26, 2016 ... drugs market growth is the emergence of new treatments. ... astaxanthin therapies for osteoarthritis treatment. The therapy is expected ... Moreover, Arthritis Research UK is conducting studies to develop ... arcOGEN study, where the genes involved in osteoarthritis are ...
(Date:5/25/2016)... , May 25,2016 FDA ... near-infrared Cellvizio platform for urological and surgical applications ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... milestone in the US with the 12 th ... Drug Administration (FDA). This new FDA clearance covers ...
(Date:5/25/2016)... 2016  Zymo Research Corp. announced today the ... materials that help researchers obtain the most accurate ... The rapid growth of the study of microbiomes ... standard methods to improve the reproducibility and quality ... at every step of the measurement process including ...
Breaking Medicine Technology: