Navigation Links
Study Finds Abdominal Fat Not the Prime Cause for Metabolic Syndrome

Researchers have found that abdominal fat is not the primary factor for causing metabolic syndrome but insulin resistance also plays a part in leading to a cluster of conditions that includes the most dangerous heart attack risk factors including pre-diabetes, diabetes, high blood pressure, and changes in cholesterol.

Abdominal fat or the spare tire that many of us carry has long been linked to metabolic syndrome, a combination of medical disorders that increase one's risk for cardiovascular disease and diabetes.

However, the study conducted by a team of researchers led by Gerald I. Shulman and Kitt Falk Petersen at Howard Hughes Medical Institute (HHMI), Yale University School of Medicin, found otherwise.

Insulin resistance is a condition in which the body's cells become resistant to insulin, a hormone secreted by the pancreas that plays an essential role in regulating the carbohydrates, lipids, and proteins obtained from food.

As part of the study, researchers used powerful new magnetic resonance imaging techniques to observe how nutrients are channelled in the body in both insulin resistant and insulin sensitive human subjects which included young, lean, non-smoking, healthy people who were sedentary and matched for physical activity.

The volunteers had no confounding factors typically associated with obesity and type 2 diabetes, which have been thought to play a key role in the pathogenesis of the metabolic syndrome, apart from insulin resistance in one cohort.

Researchers provided the volunteers with two meals high in carbohydrates, and turned to magnetic resonance spectroscopy to measure the production of liver and muscle triglyceride, the storage form of fat, glycogen, and carbohydrate.

The study found that in the insulin resistant subjects, the energy obtained from their carbohydrate rich meals was rerouted to liver triglyceride production, elevating triglyceri des in the blood by as much as 60 percent and lowering HDL cholesterol, the good cholesterol by 20 percent.

"What we found is that (insulin) sensitive individuals took the energy from carbohydrate in the meals and stored it away as glycogen in both liver and muscle," Shulman said.

"In contrast to the young, lean, insulin-sensitive subjects, who stored most of their ingested energy as liver and muscle glycogen, the young, lean, insulin-resistant subjects had a marked defect in muscle glycogen synthesis and diverted much more of their ingested carbohydrate into liver fat production, the researchers said.

The study demonstrated that insulin resistance in skeletal muscle, caused by decreased ability of muscle to make glycogen, the stored form of carbohydrate from food energy, can promote an elevated pattern of lipids or fats in the bloodstream that underpins the metabolic syndrome.

Researchers also found that skeletal muscle insulin resistance preceded the development of insulin resistance in liver cells, and that fat production in the liver was increased.

The findings of the study were published in the July issue of the Proceedings of the National Academy of Sciences (PNAS).


Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:

(Date:11/30/2015)... ... 30, 2015 , ... The Progressive Dental Institute ... 29 and 30, 2016. The course welcomes dental professionals and members of their ... how to better succeed in the modern dental marketplace. The course combines presentations ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... key disease-causing component of bacteria could be effective in fighting methicillin-resistant Staphylococcus aureus ... State University. , Their study showed that small molecule analogs that target the ...
(Date:11/30/2015)... NJ (PRWEB) , ... November 30, 2015 , ... Dr. ... With three office locations, patients can visit Dr. Margulies to experience the best available ... to hold the title of "NJ Top Dentist"! , Orthodontics is the branch of ...
(Date:11/30/2015)... ... November 30, 2015 , ... ”Dying Words: The AIDS Reporting ... on December 1, 2015, to coincide with World AIDS Day. The multi-media project will ... covered the AIDS epidemic as he was dying of the disease. , A collaborative ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to RF Safe, the ... scientist at Consumer Reports as supporting a “A Call for Clarity” on cell ... The original Nov 2015 CR story titled, “Does Cell-Phone Radiation Cause Cancer?” ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015 iCAD, Inc. (Nasdaq: ... feature its latest solutions for advanced image analysis ... cancer at the Radiological Society of North American ... from November 29 to December 4, ... including iReveal®, an automated breast density assessment solution, ...
(Date:11/30/2015)... 30, 2015  Hanger, Inc. (NYSE: HGR ) ... the terms of its previously announced consent solicitation (as ... $200,000,000 aggregate principal amount 7⅛% Senior Notes due 2018 ... consent fees payable pursuant to the Consent Solicitation, (ii) ... (iii) the expiration date of the Consent Solicitation.    ...
(Date:11/30/2015)... , November 30, 2015 Mexico Healthcare and ... Life Sciences Report 2015 . --> Pharmaboardroom releases its ... Latin America , a country of over ... a country of over 122 million people. --> It ... pharmaceuticals, or life sciences insights into the second largest pharma and ...
Breaking Medicine Technology: