Navigation Links
Study Confirms No HRT Benefit for Older Women

New evidence confirms that hormone replacement therapy (HRT) should not be prescribed to older women who are many years past menopause to help prevent chronic conditions such as heart disease .

But the authors support the view that HRT is a safe short term treatment for younger women in early menopause to relieve symptoms and improve quality of life.

In 2002, the Womens Health Initiative (WHI) trial found that postmenopausal women taking HRT had more heart attacks and strokes than non-HRT users. The trial was halted early and millions of women around the world stopped taking HRT. But scientists now believe that these risks may only apply to older women who do not normally use HRT.

In 1999, another trial (WISDOM) began to assess the long-term risks and benefits of HRT after the menopause. This trial was also stopped after the first WHI results appeared, but the WISDOM findings, published today, make an important contribution to the body of knowledge about HRT when it is initiated in older postmenopausal women.

The WISDOM team identified 5,692 healthy women registered at general practices in the UK, Australia and New Zealand with an average age of 63 years and 15 years after the menopause.

The women who had not had a hysterectomy were split at random into two groups. One was given a daily dose of combined hormone therapy (oestrogen and progestogen) and the other group was given a placebo pill. Women who had had a hysterectomy were split between combined hormone treatment, oestrogen only and a placebo.

All women were monitored for an average of 12 months and main outcomes such as cardiovascular disease, osteoporotic fractures, breast cancer and deaths, were recorded.

There was a significant increase in the number of major cardiovascular events (angina, heart attack or sudden coronary death) and blood clots (venous thromboembolisms) in the combined hormone therapy group compar ed to the placebo group. However, rates for cerebrovascular disease, breast or other cancers, fractures and overall deaths were not significantly different in these two groups.

This study confirms an early increase in thromboembolic and cardiovascular risk in older women starting hormone replacement therapy many years after the menopause, say the authors.

It shows that there is no overall disease prevention benefit, and some potential risk, for women who start hormone replacement therapy many years after menopause.

The results are also consistent with the early findings of the WHI and other trials, and support the conclusion that combined oestrogen and progestogen therapy should not be initiated to prevent cardiovascular disease in older postmenopausal women.

However, the authors stress that these results cannot necessarily be applied to younger menopausal women starting hormone replacement therapy to relieve symptoms such as hot flushes and night sweats. For these women, recent studies suggest there may be cardiovascular benefits of taking HRT around the time of menopause. The authors say that more research is needed to assess conclusively the long term benefits and risks among these women.

Those helping women make choices about treatment should consider both the results and limitations of the WHI and WISDOM trials, particularly those women who may be influenced by the timing of initiation of hormone replacement therapy, they conclude.

In an accompanying editorial, Dr Helen Roberts at the University of Auckland says that this study does not change current advice to postmenopausal women. Healthy women in early menopause are unlikely to face substantially increased risks when using hormones for a few years, she writes. However, long term use of hormone replacement therapy to prevent chronic disease is no longer recommended as the available randomised evidence shows that the negative outcomes outweigh the positive benefits.


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/1/2017)... York, NY & Greenwich, CT (PRWEB) , ... March 01, 2017 ... ... many runners, especially in the winter months when people don’t want to stop training ... the knees – and setting the treadmill to a small incline can help protect ...
(Date:3/1/2017)... ... , ... “McFarnia”: a suspenseful tale of a father who vanishes without a ... disappearance. “McFarnia” is the creation of published author Tony Pierzchala, a former Army man, ... a Chaplain with Transport for Christ at a truck stop in the Greensboro area. ...
(Date:3/1/2017)... ... ... of Love”: a tale of young love and war. ““Letter of Love”” is the ... Salvador, wife, mother, and co-founder of a Christian College. , “I turned to ... poor communities, and I study psychology. I lived the civil war. ” --Maria Teresa ...
(Date:3/1/2017)... ... , ... “The Affair is Over Now Go Live Your Life Abundantly”: a ... affair. “The Affair is Over Now Go Live Your Life Abundantly” is the creation ... dedicated her professional life to teaching and writing about marriage and family life in ...
(Date:2/28/2017)... ... , ... Answering strong demand for its medical device software design and development ... in the Soma neighborhood in San Francisco on March 1, 2017. The opening also ... systems architecture subject matter experts. , Orthogonal serves a sizeable clientele in the Bay ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... DIEGO , March 1, 2017  Aethlon ... European Patent Office has granted European Patent Number ... In recent years, exosomes have emerged ... a wide range of disease conditions, including cancer, ... (CTE).  This granted European Patent is an important ...
(Date:3/1/2017)... 1, 2017  Numotion, the nation,s leading provider of ... Tek RMD ("robotic mobilization device") by Matia Robotics in ... is a motorized standing movement device that offers the ... to complete everyday activities from a standing position. Unlike ... RMD unassisted. Numotion is the exclusive distributor of the ...
(Date:3/1/2017)... ... and Markets has announced the addition of the "Global Infertility ... The Global Infertility Therapy Partnering Terms and Agreements since 2010 ... into by the world,s leading healthcare companies. The report ... discovery or development stage whereby the licensee obtains a right or ...
Breaking Medicine Technology: