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Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

between those taking ART and those who were therapy na?ve. Males tended to have a higher risk of LEE than females.

The authors noted that one potential limitation of the study was that HCV-positive patients who were non-viraemic were analysed as being HCV coinfected; but, in a sample of the cohort, there was only a small proportion of patients with HCV antibodies and undetectable HCV RNA. Data on alcohol intake were also not included in the multivariate analysis.

Of clinical significance in this study were that there was no increase in the risk of LEE for patients on ART and that the risk of LEE in coinfected patients is not modified by the use of ART. Longer follow-up is needed to confirm these findings. Also of interest would be further explanation of a male gender-associated risk of LEE.



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