Navigation Links
Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

Many HIV/hepatitis coinfected individuals on antiretroviral therapy (ART) experience liver enzyme elevation (LEE), and for that reason,// caution is generally advised when prescribing ART in this population. Results from the ICoNA (Italian Cohort of Na?ve for Antiretrovirals) study indicate that coinfection itself may be the major risk factor for LEE.

The study investigated whether coinfected individuals on antiretroviral therapy had a higher risk of LEE than coinfected patients who were not on therapy. Results indicate this may not be the case.

ICoNA is an Italian prospective observational study of HIV-infected patients enrolled when na?ve for antiretroviral therapy. Included in this analysis were patients with one or more positive HCV antibody tests and more than one positive HBV surface antigen. Patients who began ART with one or two drugs were excluded from the analysis, as were those with signs and symptoms of acute hepatitis.

LEE was defined as alanine aminotransferase (ALT) levels (>5 x the baseline level or >3.5 x baseline when the baseline was >40 IU/l). Changes of ALT from time of enrolment in the study were analysed as a continuous variable to see if findings were affected by the choice of a cut-off point to define elevation.

HBV or HCV coinfection, use of ART, baseline ALT, and demographics were analysed using Poisson regression with generalized estimating equation correction to identify the most important predictors for the development of LEE. Demographics included age, body mass index, African origin, and risk factors for HIV infection.

The analysis included 5,272 patients of whom 30% were female, 39% were intravenous drug users, and nearly 48% were HCV/HBV coinfected. In the 18,259 person years follow-up, there were 275 episodes of LEE. The use of ART did not significantly increase the risk of LEE (adjusted RR 1.19); however, coinfection did (adjusted RR 5.07) with no significant differences
'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
(Date:5/29/2015)... University, the first cannabis college in America, will return to Las ... demanded Basic and Advanced Classic Seminars on June ... each day. Certification is available upon completion of the seminars and ... 14 from 12:00 pm to 6:00 pm. Both the seminars and ... Casino in downtown Las Vegas. , Seminar topics covered ...
(Date:5/29/2015)... Dr. Rodger Murphree, author of Treating ... now offering free weekly call in teleconferences each ... to reduce symptoms associated with fibromyalgia including chronic ... fog. , To find out more about ... in teleconferences simply go to http://www.endfibronow.com ...
(Date:5/29/2015)... 29, 2015 Designed with the versatile ... to create an all new, exclusive line of supplementation ... with the latest and greatest, high impact, result driven ... be effective. The 24/7 Series can be used by ... even the casual fitness enthusiasts. There are no stimulant ...
(Date:5/29/2015)... 29, 2015 Healthpointe’s electromyography and ... the Los Angeles County clinics including its newest ... now being offered at all Healthpointe locations throughout ... San Bernardino County. , As the muscles ... send electrical impulses throughout the body and dictate ...
(Date:5/29/2015)... 2015 As spring has sprung and ... outdoor saunas have increased in popularity as people finish ... at summer cottages. While a perennial favorite, the ... projects a few weeks earlier than usual. , Similar ... lot sizes tend to prefer the Patio series rooms ...
Breaking Medicine News(10 mins):Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 2Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 3Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 2Health News:BPI Sports and Bodybuilding.com Partner Up to Bring an Innovative New Line of Supplements 3Health News:Healthpointe Is Now Offering EMG and NCV Diagnostics at All Clinics throughout Southern California. 2Health News:As Summer Approaches, Finnleo Notes Increased Interest in Patio and Metro Outdoor Saunas 2
... to Other Food ManufacturersCHICAGO, April 1 Fonterra ... water in New Zealand, called Whole. The product, ... first for the market, and food and beverage ... markets can currently leverage the product,s constituent ingredients. ...
... Largest Independent Online Retailer of Beauty and Skin-Care ... 24 Sandow Media, parent company of ... and Salu Beauty, parent company of SkinStore.com, today ... reach for beauty product manufacturers. This powerful new ...
... HLS ) today announced it will host an investor ... 2009, to discuss its results for the first quarter of ... 406-5369 and giving the pass code 91485741. International callers should ... call approximately 10 minutes before the start of the call ...
... p.m. EDT -- SOUTH SAN FRANCISCO, Calif., April ... ) today announced the execution of a securities purchase ... of up to $43.5 million in a tranched financing, ... stock and common stock warrants, and a tranche of ...
... April 1 Misonix, Inc. (Nasdaq: MSON ... technology, which in Europe is used for the ablation ... has entered into a new, three year, exclusive distribution ... for the distribution of the SonaStar(TM) Ultrasonic Surgical Aspirator ...
... suggests link to modifiable maternal habit, , , WEDNESDAY, April ... infants sleeping on their stomachs as the greatest modifiable ... Australian researchers suggest. , They found that when mothers ... them in response to a life-threatening situation, is altered, ...
Cached Medicine News:Health News:Fonterra's New ClearProtein(TM) Satiety Water a First for New Zealand Market 2Health News:Fonterra's New ClearProtein(TM) Satiety Water a First for New Zealand Market 3Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 2Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 3Health News:HealthSouth Announces Date of 2009 First Quarter Earnings Conference Call 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 3Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 4Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 5Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 6Health News:Misonix Announces New Distribution Agreement for Belgium and Luxembourg 2Health News:Misonix Announces New Distribution Agreement for Belgium and Luxembourg 3Health News:Mom's Smoking May Lead to SIDS 2
(Date:5/29/2015)... MEMPHIS, Tenn. , May 29, 2015  Dr. ... his practice to resolve vaginal health issues often caused by ... painless and requires no anesthesia, received FDA clearance in 2014. ... Tennessee to offer the special fractional CO ... well as breast cancer survivors. In 2010 ...
(Date:5/29/2015)... May 29, 2015  The annual customer satisfaction survey ... Praxis EMR as #1 across all specialties. Every year, ... LLC conducts a poll of EHR users and publishes ...   Praxis EMR topped 348 other ... performance based criteria used by Black Book. In addition ...
(Date:5/29/2015)... BOSTON , May 29, 2015 /PRNewswire/ ... custom automation, and contract manufacturing, and Vaxxas , ... drug delivery technology, have been named winners of the ... Nanopatch Jet Coating Instrument , an advanced technology platform ... development.  The award was announced last evening at the ...
Breaking Medicine Technology:The Newest FDA-Cleared Breakthrough In Women's Health Treatments 2Praxis EMR Ranks #1 for Physician Satisfaction in Black Book's 2015 Survey of Solo and Small Practices 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 2Invetech And Vaxxas Named Recipients Of The 2015 Good Design Award For Development Of Nanopatch Jet Coating Instrument For Needle-Free Drug Delivery 3
... BETHESDA, Md., March 26, 2007--Having a build-up of ... heart attacks and,death from heart disease in multiple ... Study of Atherosclerosis (MESA),funded by the National Heart, ... Health. Previous studies have shown that,increased coronary artery ...
... WIRE)--Mar 26, 2007 - Two-year results from,the ... positive,clinical profile of the Endeavor(R) drug-eluting coronary ... of Endeavor patients who have at,least two ... patients, there have been no reported cases ...
Cached Medicine Technology:Calcium Plaque Build-up in the Arteries Leads to Coronary Heart,Disease in Multi-Ethnic Groups 2Two-Year Results from the Medtronic ENDEAVOR III Trial Confirm,Stent's Positive Clinical Profile 2Two-Year Results from the Medtronic ENDEAVOR III Trial Confirm,Stent's Positive Clinical Profile 3
The Needle Loading Platform / Shield is designed to provide superior operator shielding during the loading of prostate implant needles with iodine or palladium seeds. It is constructed of 3/8" alumin...
The seed alignment tray aligns seeds and spacers for easy access to be picked up by the SeedVac™. It also interfaces with the seed sterilization and sorting tray for protection from radiation....
MT-BT-5011-25 Prostate seeding needle (set of 25 unloaded needles).,MT-BT-5011-P Prostate seeding needle, pre-plugged and pre-sterilized, unloaded or for use with MEDTECs ASAP™ pre-load seedin...
... ACMI™ offers five classes of ... vaporization, cutting loops, knife, roller bar ... are the only electrodes specifically integrated ... surgical tissue removal with minimal bleeding, ...
Medicine Products: