Navigation Links
Study Aims to Find Which Breast Cancer Patients Need Chemotherapy

Most postmenopausal women with small breast tumors don’t need chemotherapy to reduce their recurrence risk after lumpectomy//.

To try to determine who does, a test that measures a tumor’s aggressiveness based on its DNA will be tested nationally in more than 10,000 of these women.

“The dilemma physicians have with these patients is, because they have such small tumors, it’s hard to tell who needs chemotherapy,” said Dr. Thomas A. Samuel, Medical College of Georgia hematologist/oncologist specializing in breast cancer and a study principal investigator.

If you take 100 postmenopausal women with a small tumor that has estrogen receptors – most do – and no sign the disease has spread to the lymph nodes, probably 12 to 15 of the women need chemotherapy to reduce recurrence, Dr. Samuel says.

To save those patients’ lives, all 100 have to be treated with chemotherapy, because no definitive test indicates who really needs it, says Dr. Samuel. Yet the vast majority will do well with lumpectomy, radiation and hormone therapy that keeps cells from being refueled by estrogen.

Although chemotherapy is a powerful tool, he’s seen many patients struggle with notorious side effects such as hair loss, nausea, vomiting and increased risk for leukemia and heart problems. Some patients even opt to stop treatment. “I know that a number of these patients probably don’t need it but there is no way for me to know who they are ahead of time. I think this trial will help us find who should get it and who should not.”

“The Oncotype DX? looks at the DNA of the breast cancer cells and tells us if this cancer is more likely to spread or grow,” says Dr. Samuel of the commercially-available test that looks at 16 tumor genes and uses five reference genes as controls. “How cancers behave largely depends on what the DNA is like.”

Although it’s been on the market more than a year, the test is not widely used, possibly because its efficacy was studied in a relatively small number of women and it costs several thousand dollars, says Dr. Samuel, who used the test only twice before the study.

If the federally funded study of thousands of women over the next five-plus years backs up smaller studies, the test likely will become part of the standard of care for this group of women, he says.

The Trial Assigning Individualized Options for Treatment, or TAILORx trial, coordinated by the Eastern Oncology Group, is the first study resulting from the National Cancer Institute’s Program for the Assessment of Clinical Cancer Tests.

Enrollees with the lowest recurrence scores will have radiation therapy and hormonal treatment following lumpectomy. Those with the highest will also get chemotherapy. “The debate is in the intermediate risk group. That is where most women fall and the ones where we are not really sure what to do,” Dr. Samuel says. That majority of patients will be randomized to either get chemotherapy or not.

Dr. Samuel hopes to enroll about two patients per month; the trial likely will be open several years depending on how long it takes to get a total of 10,000 nationally. Participants will be followed for at least five years.

He notes the highest risk for recurrence is within two years after diagnosis. While the risk never goes away, it is very low after the five-year mark.

Breast cancer is most common in postmenopausal women and chemotherapy, tends to cause even more problems in older women, Dr. Samuel notes.

In fact, in this group of patients hormonal therapy is probably better tolerated and more efficacious, he says. Any patient who has a lumpectomy needs radiation therapy on remaining breast tissue. “We add chemotherapy if the tumor is big enough and we think the risk is high enough that the cancer may come back,” says Dr. Samuel. Chemotherapy must precede radiation therapy because it worse ns the toxicity related to radiation. When patients get both, the treatment course can last eight to nine months. “If we can better determine who needs chemotherapy, we can shorten that time significantly,” Dr. Samuel says. Hormonal therapy comes last and can exceed five years.

Source-Bi-Bio Technology
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... ... February 09, 2016 , ... ... to expand access to affordable hearing aids , increase industry transparency, and ... in the United States. , “For the average consumer, the hearing aid industry ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... sealing company , is proud to announce that many of their franchises have ... customer service. The hard surface restoration franchises received customer recognition through positive reviews ...
(Date:2/8/2016)... ... 08, 2016 , ... The Federal Laboratory Consortium for Technology ... site houses a wealth of federal resources that businesses can leverage to further ... transfer (T2). As a network of over 300 federal laboratories, the FLC’s mission ...
(Date:2/8/2016)... ... ... who has struggled to quit smoking, a man who has struggled with hair loss – ... his problems – and he did. Now Nabat, a serial entrepreneur featured as the October ... to the world and better people's lives. His own experience with nicotine addiction led to ...
(Date:2/8/2016)... ... 2016 , ... The Bell Agency, a full service insurance ... their ongoing community enrichment program. The current campaign fundraises for Angels & Doves, ... being accepted at: http://www.angelsanddoves.com/donate.html . , Angels & Doves was founded in ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... DUBLIN , Feb. 9, 2016  Jazz Pharmaceuticals ... will report its 2015 fourth quarter and full year ... close of the financial markets.  Company management will host ... 4:30 p.m. EST/9:30 p.m. GMT to discuss fourth quarter ... business and financial update and guidance for 2016 financial ...
(Date:2/9/2016)... February 9, 2016 Amarantus BioScience ... on developing products for Regenerative Medicine, Neurology and Orphan ... presenting company at Source Capital Group,s 2016 Disruptive Growth ... 2016 in New York City . ... 10, 2016 at 12:30 pm by Gerald E. ...
(Date:2/9/2016)... , Feb. 9, 2016 The new report "Global Blood Monitoring ... Acuity Business Research & Consulting group reveals that global market for ... million in 2014 and expected to grow to US$ 24,830.1 million ... North America , Europe ... , Middle-East and Africa ...
Breaking Medicine Technology: