Navigation Links
Studies Reveal Inappropriate Use Of Drug-Coated Stents

Drug-releasing stents, till recently the rage among doctors treating patients with blocked arteries, do not seem as promising now. Studies currently link them with a low, but serious risk of fatal complications arising from blood clots.

The research by American scientists in two different studies published in the Journal of the American Medical Association show that many doctors have stretched the limit of their use- testing the effectiveness of such stents, even in unapproved conditions.

Drug-releasing stents or drug- eluting stents refer to stents, which have impregnated drugs that release slowly, in order to keep arteries open. The previous models with such drugs were plain metal stents i.e. wire-meshed tubes used to prop up de-clogged arteries.

When they were first approved for U.S. sale three years ago, the drug-infused devices were heralded as a revolution because they dramatically reduced the chances of an artery closing again.

The newer devices quickly supplanted the older bare-metal versions, generating almost 90 percent of all stent sales by early 2006 and creating a $6 billion market.

Yet studies reveal that off-label or untested use of drug-coated stents make up almost half of all uses of these devices for doctors treating blocked coronary arteries. However, even though the risk for complications is higher with off-label use, the absolute rate for patients are still low overall, the researchers say.

In one study of 5,541 patients, Dr. Nirat Beohar of Northwestern Memorial Hospital in Chicago and colleagues found the risk of death, heart attack or blood clots more than doubled 30 days after drug-eluting stents were used in patients with conditions such as acute heart attack.

But the overall complication rate was relatively low at 2.5 percent, despite their use in high-risk patients.

Says Dr. Charles Davidson, one of the study's authors:'I look at this study as be ing very reassuring. Once you adjust for the more complex patient, there really is no safety issue.'

According to Davidson, drug-eluting stents are slightly less effective at keeping arteries clear in these sicker patients, but they are still much better than bare-metal stents because there are far fewer instances of restenosis, or artery reclogging.

In a second study of 3,323 patients treated with drug-eluting stents in 2004 and 2005, 54.7 percent of the patients were treated off label.

'Clinicians should be cautious about extrapolating the benefits of drug-eluting stents over bare metal stents,' the researchers were quoted.

So, what should a patient choose in this situation? Robert A. Harrington of Duke University and director of the Duke Clinical Research Institute opines that the problem is that the U.S. device-safety system is flawed. There simply isn't a reliable system for systematically following up on and reporting what happens when newly approved implanted devices are used in the real world.

So what patients should do, Harrington says, is ask to their doctors about the evidence that a drug-coated stent would be effective and safe for them as individuals.

If a patient is in the 'on-label' group, the evidence is good. If the patient is in the 'off-label' group, there isn't a lot of evidence and doctors should explain why they think a drug-coated stent's benefits might outweigh its risks.

Says Harrington:' Doctors need to say, yes, we know that when we use these devices off label, there is a higher risk. 'The doctor should say, 'Here is how I interpret the evidence available, and here is how it applies to your situation.' This does not mean don't use the stents outside their approved indications, but if you start to do that, you'd better have a pretty good reading on what the risks are.'

In conclusion, all experts stress one additional point: Anyone who gets a drug-c oated stent, on- or off-label, must be willing to take anticlotting medications for a year or more.


Related medicine news :

1. Studies On Hearing Loss Discovers New Causes
2. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
3. Cure For Autism Could Be Established Through Hamster Studies
4. Despite More Studies Researchers Are Still Confound With ADHD
5. Studies Show Brain becomes Less Specialized With Age
6. ISB To Establish Research Chair On Real Estate And Urban Studies
7. Studies Show Combination Drugs As A Poor Substitute For Anti-Coagulants In Stroke
8. Further Studies Needed To Completely Understand About Ventricular Fibrillation
9. Studies Report Mammograms Unsafe
10. Six Indians Win Australian Studies Fellowships
11. Circumcision Studies to Continue Says Health Panel
Post Your Comments:

(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated ... latest FDA requirements, which stipulates new criteria regarding medical device manufacture ... Medical ID jewelry such as Medical ID Bracelets, can rest assured ... of the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process ...
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
Breaking Medicine Technology: