Navigation Links
Studies Reveal Inappropriate Use Of Drug-Coated Stents

Drug-releasing stents, till recently the rage among doctors treating patients with blocked arteries, do not seem as promising now. Studies currently link them with a low, but serious risk of fatal complications arising from blood clots.

The research by American scientists in two different studies published in the Journal of the American Medical Association show that many doctors have stretched the limit of their use- testing the effectiveness of such stents, even in unapproved conditions.

Drug-releasing stents or drug- eluting stents refer to stents, which have impregnated drugs that release slowly, in order to keep arteries open. The previous models with such drugs were plain metal stents i.e. wire-meshed tubes used to prop up de-clogged arteries.

When they were first approved for U.S. sale three years ago, the drug-infused devices were heralded as a revolution because they dramatically reduced the chances of an artery closing again.

The newer devices quickly supplanted the older bare-metal versions, generating almost 90 percent of all stent sales by early 2006 and creating a $6 billion market.

Yet studies reveal that off-label or untested use of drug-coated stents make up almost half of all uses of these devices for doctors treating blocked coronary arteries. However, even though the risk for complications is higher with off-label use, the absolute rate for patients are still low overall, the researchers say.

In one study of 5,541 patients, Dr. Nirat Beohar of Northwestern Memorial Hospital in Chicago and colleagues found the risk of death, heart attack or blood clots more than doubled 30 days after drug-eluting stents were used in patients with conditions such as acute heart attack.

But the overall complication rate was relatively low at 2.5 percent, despite their use in high-risk patients.

Says Dr. Charles Davidson, one of the study's authors:'I look at this study as be ing very reassuring. Once you adjust for the more complex patient, there really is no safety issue.'

According to Davidson, drug-eluting stents are slightly less effective at keeping arteries clear in these sicker patients, but they are still much better than bare-metal stents because there are far fewer instances of restenosis, or artery reclogging.

In a second study of 3,323 patients treated with drug-eluting stents in 2004 and 2005, 54.7 percent of the patients were treated off label.

'Clinicians should be cautious about extrapolating the benefits of drug-eluting stents over bare metal stents,' the researchers were quoted.

So, what should a patient choose in this situation? Robert A. Harrington of Duke University and director of the Duke Clinical Research Institute opines that the problem is that the U.S. device-safety system is flawed. There simply isn't a reliable system for systematically following up on and reporting what happens when newly approved implanted devices are used in the real world.

So what patients should do, Harrington says, is ask to their doctors about the evidence that a drug-coated stent would be effective and safe for them as individuals.

If a patient is in the 'on-label' group, the evidence is good. If the patient is in the 'off-label' group, there isn't a lot of evidence and doctors should explain why they think a drug-coated stent's benefits might outweigh its risks.

Says Harrington:' Doctors need to say, yes, we know that when we use these devices off label, there is a higher risk. 'The doctor should say, 'Here is how I interpret the evidence available, and here is how it applies to your situation.' This does not mean don't use the stents outside their approved indications, but if you start to do that, you'd better have a pretty good reading on what the risks are.'

In conclusion, all experts stress one additional point: Anyone who gets a drug-c oated stent, on- or off-label, must be willing to take anticlotting medications for a year or more.


'"/>




Related medicine news :

1. Studies On Hearing Loss Discovers New Causes
2. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
3. Cure For Autism Could Be Established Through Hamster Studies
4. Despite More Studies Researchers Are Still Confound With ADHD
5. Studies Show Brain becomes Less Specialized With Age
6. ISB To Establish Research Chair On Real Estate And Urban Studies
7. Studies Show Combination Drugs As A Poor Substitute For Anti-Coagulants In Stroke
8. Further Studies Needed To Completely Understand About Ventricular Fibrillation
9. Studies Report Mammograms Unsafe
10. Six Indians Win Australian Studies Fellowships
11. Circumcision Studies to Continue Says Health Panel
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations ... Latin America . ... ... ... ...
Breaking Medicine Technology: