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Studies Identify Interactions Between Heart Disease, Kidney Disease

Anemia and other conditions related to chronic kidney disease are independently associated with the risk of cardiovascular disease ; conversely, heart disease is associated with a decline in kidney function and the development of kidney disease, according to two reports in the issue of Archives of Internal Medicine.

Chronic kidney disease is becoming increasingly prevalent in the United States and worldwide, according to background information in the articles. Chronic kidney disease is associated with a wide variety of complications, including anemia (low red blood cell count, or red blood cells that are deficient in oxygen-transporting hemoglobin), nerve pain, bone disease, death and cardiovascular disease. Most patients with chronic kidney disease die of complications from heart disease rather than of kidney failure.

In one study, Peter A. McCullough, M.D., M.P.H., of William Beaumont Hospital, Royal Oak, Mich., and colleagues assessed a group of 37,153 individuals who were screened for kidney disease through a community-based program between 2000 and 2003. The participants (average age of 52.9 years) all reported a personal or family history of diabetes, hypertension or kidney disease on a screening survey. Patients had their blood pressure measured and provided blood and urine samples, which were processed to assess three markers of chronic kidney disease:

estimated glomerular filtration rates (eGFR), or the rate at which kidneys filter blood, calculated based on levels of the waste product creatinine in the blood anemia, determined by blood hemoglobin levels and microalbuminuria, or slightly high levels (20 milligrams per liter or more) of the protein albumin in the urine.

Of the participants who were followed for a maximum of 47.5 months, 5,504 (14.8 percent) had eGFR values of less than 60 milliliters per minute per 1.73 square meters, which were considered abnormal and signs of declining kidney function
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