Navigation Links
Stubborn Ulcerative Colitis Responds to Arthritis Drug

In good news for patients with stubborn cases of ulcerative colitis, a serious intestinal disorder, a new research review suggests// that the drug infliximab can be a useful alternative if other treatments don’t work.

The drug is currently used to treat rheumatoid arthritis and Crohn’s disease.

“For people with active ulcerative colitis who do not respond to corticosteroids or immunosuppressive agents, infliximab is effective in inducing clinical remission, inducing clinical response, promoting mucosal healing and reducing the need for colectomy, at least in the short term,” said review co-author Dr. Anthony Kwaku Akobeng.

Akobeng, a gastroenterologist at Manchester Children’s University Hospitals in England, and colleagues examined seven randomized controlled studies comprising 860 patients that evaluated infliximab as a treatment for ulcerative colitis.

The review of studies appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews like this one draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic.

“Infliximab is another option if steroids fail,” said Peter Higgins, M.D., an assistant professor in gastroenterology at the University of Michigan Medical Center in Ann Arbor.

Still, infliximab “has known infectious risks, which while rare, can be fatal,” said Higgins, who was not involved with the review. He added that it’s not clear if it’s a better option than cyclosporine, another drug commonly used when other medications fail.

The disease afflicts an estimated 600,000 Americans, and occurs when ulcers form in the rectum and colon, leading to frequent diarrhea and bleeding.

According to Higgins, the causes of ulcerative colitis aren’t clear, but they may have someth ing to do with an interaction between a person’s genetic makeup and another factor, such as infection or the use of non-steroidal anti-inflammatory drugs, a class of painkillers that includes ibuprofen (Advil) and naproxen (Aleve).

The interactions may cause “an abnormal interaction between bacteria in the gut and the immune system,” Higgins said.

Meanwhile, “mechanisms that lead to a reduction of inflammation in response to bacterial products are defective, so the body has a hard time ‘resetting’ itself, and the inflammation becomes chronic,” said Gerald Dryden, Jr., M.D., an associate professor at the University of Louisville in Kentucky.

There are a number of drug treatments for colitis, including steroids, which reduce inflammation by dampening the body’s immune system, and aminosalicylates, which also help control inflammation.

In some cases, however, the colon must be removed; some patients must use colostomy bags for the rest of their lives.

In recent years, researchers have begun looking at infliximab — also known by the brand name Remicade — as a possible treatment for moderate and severe colitis.

In the review studies, patients were given either infliximab or a placebo for moderate and severe cases of ulcerative colitis. All the patients failed treatment with steroids and/or other drugs that suppress the immune system.

Three intravenous infusions of infliximab (at zero, two and six weeks) were 3.2 times more likely than placebos to lead to remission of symptoms and two times more likely to induce a clinical response at eight weeks.

The researchers also found that a single infusion of infliximab was more effective than placebo in reducing the need for colectomy within three months.

Serious side effects were “not common” in the studies, but the authors report that infliximab can be dangerous to some patients.

The drug has been used to tre at rheumatoid arthritis and Crohn’s disease, an intestinal disorder that is closely linked to colitis. Infliximab appears to tinker with a protein known as tumor necrosis factor alpha that contributes to inflammation.

“There are some theories that this drug works by inducing ‘apoptosis,’ which means programmed cell death,” Dryden said. “In other words, inflammatory cells, which are contributing to the disease state, will ‘die’ as a result of this medication.”

Both Higgins and Dryden praised the review. However, Higgins said a limitation was the small number of studies and Dryden said that the review didn’t offer a comparison with cyclosporine.

“Looking at the published studies, infliximab appears to be less effective than cyclosporine, but less toxic,” Higgins said. “However, the two agents have never been compared head to head, so it is difficult to know how they would compare in similar patients.”

What should patients think about this research? The review suggests that infliximab does benefit patients, Dryden said.

However, it’s not clear if the drug actually improves the lives of patients enough that they feel “back to their normal baseline,” Dryden said. “There is still room for improvement.



Source-Newswise
SRM
'"/>




Related medicine news :

1. Bifidogenic Growth Stimulator: A Non-Toxic Way To Treat Ulcerative Colitis
2. Bifidogenic Growth Stimulator: A Non-Toxic Way To Treat Ulcerative Colitis
3. Acute Gastroenteritis Responds To Treatment With Either Gatorade Or Pedialyte
4. Marijuana Abuse Responds to Psychotherapy, Overall Is Hard to Treat
5. Brain Responds Better to Name Brands
6. Another ray of hope for Arthritis Sufferers
7. Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
8. B Vitamin protects and lowers toxicity of Arthritis Drug
9. FDA Approves New Arthritis Drug, Bextra
10. Risk Of Developing Arthritis
11. Arthritis Drug May Cause Liver Damage
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... ... Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair ... hour by 2020 and then adjusting it yearly to increase at the same rate as ... the wage floor does not erode again, and make future increases more predictable. , The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: