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Structure of TB Enzyme Points the Way to New Drugs: Study

ign compounds that are highly effective against PknG," said Pieters.

Tuberculosis kills millions of people every year, and many millions more carry the bug in a latent form.

Antibiotics that are used to treat the illness are decades old, can be toxic and don't work on the bacteria in its dormant stage. What's more, some virulent strains of the airborne germ have emerged that are extensively drug resistant.

Pieters said that the new drugs by targeting different pathways than those used by existing antibiotics should side-step various problems with these drugs, specifically their inability to destroy the bacteria in its dormant form, which is one of the reasons that resistance has emerged.

The study appears in the Proceedings of the National Academy of Sciences.


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