Navigation Links
Structure of DNA-modifying enzyme In Small Pox Determined

cture was determined in a collaborative effort between the Bushman lab and the lab of the other senior author Gregory D. Van Duyne, PhD, Professor of Biochemistry and Biophysics and an Investigator with the Howard Hughes Medical Institute (HHMI). Using purified topoisomerase enzyme that had been expressed in bacterial cells, they bound the enzyme to short segments of DNA that contained the viral topoisomerase's specific recognition sequence. They then determined the three-dimensional structure of the topoisomerase-DNA complex using X-ray crystallography.

One of the primary differences between the viral topoisomerase enzyme and the closely related human enzyme that functions in the nucleus of all human cells is that the viral enzyme only relaxes supercoiled DNA when it binds to specific DNA sequences. The structure of the poxvirus topoisomerase-DNA complex provides some important clues about how this recognition and activation mechanism works.

"The more the viral enzyme differs from the human nuclear enzyme, the more likely it is that inhibitors could be developed that are specific to the viral enzymes," says Bushman.

Knowing the three-dimensional structure of the smallpox virus topoisomerase-DNA complex will also facilitate the design of agents to combat poxvirus infections. Topoisomerases are some of the most widely targeted proteins by drugs that are intended to inhibit growth of the cell. Drugs that target topoisomerases generally stabilize an intermediate of the enzyme's reaction in which one of the DNA strands is broken. If these breaks are not repaired, the DNA cannot be replicated and the cell dies.

In the case of smallpox virus, the hope is that drugs targeted to the viral topoisomerase enzyme will prevent viral replication through a similar mechanism. The X-ray structure provides a template for designing small molecules that could stabilize the broken DNA in the intermediate form, thereby killing smallpox virus p
'"/>




Page: 1 2 3

Related medicine news :

1. Relationship Between Genetic Structure And Quality of Life
2. Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
3. Structure of the brain to increase risk for anxiety disorders
4. Changes In Brain Structure From Methamphetamine Abuse And HIV Infection
5. Almond Structure in the Brain Intrigues Researchers
6. Controversy over Fees Structure in Private Medical Colleges
7. Controversy Over The Fee Structure In Private Medical Colleges Surfaces Yet Again
8. Education Structure In Indian Schools To Be Revamped Soon
9. Neither Management Nor Students Happy With New Fee Structure
10. DNA-bound p53 Tumor Suppressor Protein Structure Determined
11. Penn Researchers Throw Light on the Structure Of Smallpox Virus Protein
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Structure DNA modifying enzyme Small Pox Determined

(Date:12/26/2014)... 2014 Plugin and template developers from ... Plugin for Final Cut Pro X. , “TransPack Volume 5 ... to pull off an industry professional look” Said Christina Austin, ... on TransPack Volume 5, a new level of professionalism will ... of over 50 Final Cut Pro X transitions featuring organic ...
(Date:12/26/2014)... 26, 2014 Parker & Sons, ... best in heating, cooling and plumbing contractor services ... emergency services in 2014 with regard to air-conditioning ... Arizona is known for its incredibly hot summers. ... the intricacies and details of a wide variety ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – ... current treatment landscape, unmet needs, current pipeline and commercial ... anti-cancer drug which is typically used for treating colorectal ... for treating gastric cancer and pancreatic cancer. TS-1 is ... was first approved in 1999 in Japan for the ...
(Date:12/25/2014)... Angeles, CA (PRWEB) December 25, 2014 The ... Dolcemaschio was created in honor of a true 9/11 ... at two film festivals including the 24 hours of Nuremberg ... Festival in Bangladesh. , Actress, screenwriter and director ... helped produce this film together with her husband, Gregory ...
(Date:12/25/2014)... LunaDress.co.uk has updated its blog to provide professional shopping tips on ... models at LunaDress.co.uk come with big discounts, up to 80 percent ... turn out to be a most exciting memory and can show ... surprise to a wedding. On the updated fashion blog, ladies can ... a big day . , Going out with friends to a ...
Breaking Medicine News(10 mins):Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2
... , BOCA RATON, Fla., July 13 Laura E. ... and only FDA-approved microsphere-enhanced collagen filler for the correction of smile ... dermal filler. Dr. Skellchock has been an avid Artefill user the ... the correction of wrinkles. , , ...
... , DALLAS, July 13 As Americans hit the gym ... the world,s leading authority on health and fitness, is exposing some of ... have nutrition and fitness facts to help everyone reach their individual goals. ... running on a treadmill versus running outside, the fitness experts at Gold,s ...
... Amsterdam, 13 July 2009 Elsevier announced today the ... research tool developed in collaboration with the Allen Institute ... George Paxinos and Charles Watson, Prince of Wales Medical ... the Society for Neuroscience,s Neuroscience 2008 tradeshow last November, ...
... , LAS VEGAS, July 13 /PRNewswire/ -- ... welcomes its first patients today, opening the doors to an architectural ... , The Cleveland Clinic Lou Ruvo ... the research, early detection and treatment of neurological diseases, including Alzheimer,s, Huntington,s, Parkinson,s ...
... , LEXINGTON, Ky., July 13 ... its subsidiary Secure eHealth, LLC has entered into a preliminary ... CIFRA, a secure messaging and data delivery platform that will ... to Jim Renfro, VHGI President, "CIFRA will finally give healthcare ...
... Long term care costs in Idaho continue to rise at ... in or near retirement. As a leader in the long ... products to help people proactively plan for their future. Now, ... a new program designed to simplify the process of purchasing ...
Cached Medicine News:Health News:Integrative Dermatology of Boca Raton Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 2Health News:Integrative Dermatology of Boca Raton Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 3Health News:Gold's Gym Debunks America's Most Common Fitness Myths 2Health News:Gold's Gym Debunks America's Most Common Fitness Myths 3Health News:Elsevier launches official version of BrainNavigator 2Health News:Cleveland Clinic Lou Ruvo Center for Brain Health Opens for Business 2Health News:Cleveland Clinic Lou Ruvo Center for Brain Health Opens for Business 3Health News:Secure eHealth and DRM Security Partner to Provide Most Secure Healthcare Network Available 2Health News:Secure eHealth and DRM Security Partner to Provide Most Secure Healthcare Network Available 3Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Idaho AARP Members 2Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Idaho AARP Members 3Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Idaho AARP Members 4Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Idaho AARP Members 5
(Date:12/24/2014)...  Lockton Dunning Benefits, the Dallas ... addition of Vice President Kim Foerster ... Consulting team, Excelsior Solutions. Foerster ... the position.  Most recently, she worked as the ... Pharmacy, where she has held various managerial positions ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... UV disinfection robot, announced today that the General Services ... through November 2019.   This newly formed ... all levels of government purchasers, including Department of Veteran ... as Homeland Security contacts purchasing solutions for the Ebola ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... MINNEAPOLIS, May 3, 2011 Nonin Medical, Inc., the ... OEM and a leader in noninvasive physiological monitoring, announced ... 3012LP, OEM Pulse Oximeter for medical monitoring manufacturers. ... low-power, externally wired pulse oximeter will provide a new ...
... FRANCISCO, May 3, 2011 Castlight Health, the ... take control of health care costs through easy-to-use ... announced that Life Technologies Corporation has implemented the ... the U.S. Since implementation in ...
Cached Medicine Technology:Nonin Medical Launches Low Power Xpod®, Model 3012LP, OEM Pulse Oximeter Globally 2Castlight Health Enables Life Technologies to Take Control of Health Care Costs 2
... The new Chanel optical collection, ... elegance dear to Mademoiselle's heart, ... to the quilted effect. Combining ... the sparkle of Strass and ...
... a wonderfully fresh restatement of everything thats ... Salvatore Ferragamo.,The creations include eighteen ladies models ... of four Sole models.,The style icons of ... brilliant show of intriguing designs, striking details ...
... has been manufacturing the Anne Klein brand ... eyewear collections are designed for an all-female ... Anne Klein eyewear identifies herself with the ... career woman who is image-conscious and quality-conscious ...
... collections - Nike Suns, Nike Flexon Suns ... consumers the latest vision technology for both ... feature Nikes Max Lens technology that reduces ... sweet spot for optimal sport performance. New ...
Medicine Products: