Navigation Links
Stress Protein Inactivation Cuts Alzheimer's Peptide in Mice

While previous studies have already revealed that stress boosts the production of a brain peptide critical to Alzheimers disease, a new study on mice has now shown that blocking a different brain peptide slows the stress-induced increases.

The study, reported online in the Proceedings of the National Academy of Sciences by scientists from Washington University School of Medicine in St. Louis, is among the first studies to elaborate the basic biomolecular mechanisms that may underlie the increased risk of Alzheimer's disease.

Last November, the researchers had shown that the raising of genetically modified mice under isolated conditions in smaller cages accelerated the deposition of brain plaques and declines in cognitive ability. Since brain plaques are mostly comprised of a peptide known as amyloid beta, the researchers suspected that stress was increasing its levels.

In the present study, the scientists used a technique known as micro dialysis to monitor amyloid beta levels in the brains of mice exposed to the same stressorsisolation and smaller cages.

"Stress remarkably elevated soluble amyloid beta levels in the spaces between brain cells," says senior author Dr. David Holtzman, the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology.

"But we didn't know based on those initial experiments if it was a chronic effect or a much more immediate effect. If it was more immediate, we thought we might be able to identify some of the brain molecules involved in increasing the levels," he added.

Initially, the researchers suspected corticosterone molecules, the mouse equivalent of the human stress hormone cortisol, to be behind the rapid change in the levels of amyloid. But upon seeing that a large dose of corticosterone didn't cause a similar rapid change in amyloid beta levels, they began searching for molecules released in the mouse brain by stress. '"/>




Page: 1 2

Related medicine news :

1. Stress reduces your immunity- startling but true!!!!!
2. Stress can make you overweight
3. Stress response increases suicide risk
4. Stress triggers acne
5. Stress make acne worse
6. Stress may Worsen Acne
7. Stress can Trigger Heart Problems
8. The Best Way To Decrease Post-Mammogram Stress
9. Education Levels Found To Predict Stress
10. The Harmful Effects Of Stress in Young Adults
11. Diabetics To Seek Mental Counseling To Cope With Stress
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stress Protein Inactivation Cuts Alzheimer Peptide Mice

(Date:11/29/2014)... 29, 2014 ... both qualitative and quantitative analysis ... strategies preferred by key market ... the growth, and restraints in ... the opportunities in the baking ...
(Date:11/28/2014)... 2014 The emerging blend ... research in all the healthcare segments such ... support and population health management. The demand ... innovation in machine learning, logical methodologies, computational ... full report with full table of contents ...
(Date:11/28/2014)... Tbdress.com has recently announced its ... on Nov. 28, 2014. The special offer will provide ... more) at greatly discounted prices. , The website ... holiday, celebrated generally on December 25 by billions of ... sales, are always provided in December.” , Tbdress.com ...
(Date:11/28/2014)... Recently, SWAccessControl.com, a renowned smartware manufacturer, has ... all these high end products are offered at discounted ... will last from today to Dec 16, 2014. , ... launch the promotion. We are proud of our new ... latest information about our hottest items, we have listed ...
(Date:11/28/2014)... FL (PRWEB) November 28, 2014 The month ... over 20,000 car accidents occurring in Florida every year ... on the importance of auto insurance policies. , "Optional auto ... drop. Auto insurance is not cheap I know, actually Florida ... the costs are even higher, but what I see is ...
Breaking Medicine News(10 mins):Health News:Global Baking Ingredients Market with an Analysis and Forecast to 2019 - New Research Report Available at ReportsnReports.com 2Health News:Global Baking Ingredients Market with an Analysis and Forecast to 2019 - New Research Report Available at ReportsnReports.com 3Health News:Global Baking Ingredients Market with an Analysis and Forecast to 2019 - New Research Report Available at ReportsnReports.com 4Health News:Medical & Healthcare Analytics Market Report: Global Industry Size, Share, Trends, Growth and Forecast by Researchmoz.us 2Health News:Tbdress.com Announced Its Christmas Eve Sales 2Health News:New Access Control Systems Now Offered At Low Prices By Smartware Manufacturer SWAccessControl.com 2Health News:Car Accident Attorney Sean M. Cleary on Auto Insurance Policies Essential for Florida Drivers 2
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) today ... PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) for the treatment ... the Phase 2 clinical study in late June or ... the clinical trial sites. The U.S. Food and ...
... on Tumors and Tumor Blood Vessel Cells , ... subsidiary of Eisai Corporation of North America, announced that ... investigational new drug (IND) application to study MORAb-004 in ... endosialin, a protein expressed on cells associated with tumors ...
... June 9 Bruce Matter has joined healthcare IT ... for company growth and client satisfaction. Peminic, with offices ... process management solutions to over 400 acute care and ... management and legal matters. , , Teaming with ...
... Million From 2008 to 2018, According to a New Report ... Decision Resources, one of the world,s leading research and ... in the Parkinson,s disease drug market, fueled by the launch ... generic erosion of key currently-available agents. As a result, sales ...
... American Diabetes Association Meeting Validate Mechanistic and Therapeutic Potential ... , , SOUTH SAN FRANCISCO, Calif., June 9 ... three posters that validate the mechanistic activity and therapeutic ... orally-administered soluble epoxide hydrolase (sEH) inhibitor that is in ...
... Four Locations to Hold Discussions on Aging in Place throughout ... , WASHINGTON, June 9 As part of a national ... America will be hosting workshops throughout the month of June, ... Americans remain in their communities. , , Attendees ...
Cached Medicine News:Health News:Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study 2Health News:Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study 3Health News:Results From Phase 1 Clinical Study of PEG-PAL in PKU and Update on Phase 2 Clinical Study 4Health News:Morphotek(R), Inc. Announces FDA Acceptance of Investigational New Drug Application for MORAb-004, a Monoclonal Antibody for the Treatment of Solid Tumors 2Health News:Morphotek(R), Inc. Announces FDA Acceptance of Investigational New Drug Application for MORAb-004, a Monoclonal Antibody for the Treatment of Solid Tumors 3Health News:Industry Recognized and Trusted Leader, Bruce Matter, Joins Healthcare IT Company, Peminic, Inc. as Company Growth in the Areas of Patient Safety, Risk Management, and Patient Satisfaction Accelerates 2Health News:Growth in the Parkinson's Disease Drug Market, Fueled by the Launch of Several New Therapies, Will be Offset by Generic Erosion of Key Agents 2Health News:Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281 2Health News:Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281 3Health News:Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281 4Health News:How Prepared are America's Communities to Handle the Aging Boom? 2Health News:How Prepared are America's Communities to Handle the Aging Boom? 3Health News:How Prepared are America's Communities to Handle the Aging Boom? 4
(Date:11/26/2014)... The medical magnetic resonance imaging (MRI) ... with world market revenues for 2013 at $5.1 ... types of medical imaging have led to improvements ... conditions in children and adults, each imaging procedure ... Medical Imaging Markets , analyzes the current and ...
(Date:11/26/2014)... 2014 According to the ... Source (Electric, Battery, Pneumatic), by Product (Drill, Saw, ... by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) - ... Powered Surgical Instruments Market is estimated to be ... and is expected to grow at a moderate ...
(Date:11/26/2014)... SAN FRANCISCO , Nov. 25, 2014  goBalto, ... solutions, has been recognized as a winner of Red ... received a Global Top 100 North America award in ... the international technology landscape. Red Herring,s Top ... for identifying promising new companies and entrepreneurs. Red Herring ...
Breaking Medicine Technology:Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4goBalto Selected as a 2014 Red Herring Top 100 Global Company 2goBalto Selected as a 2014 Red Herring Top 100 Global Company 3
... 2012 What do the leaders of "America,s pastime," a free ... and the founder of Camp Abilities have in common? All ... life for people who are blind or visually impaired, which ... Access Awards, announced today by the American Foundation for the ...
... 27, 2012 A journal for researchers, professionals ... Elsevier , a world-leading provider of scientific, ... announce the launch of the official journal of the Society ... of Applied Research in Memory and Cognition. Published quarterly, ...
Cached Medicine Technology:American Foundation for the Blind Announces 2012 Access Award Winners 2American Foundation for the Blind Announces 2012 Access Award Winners 3Elsevier Launches New Journal: Journal of Applied Research in Memory and Cognition 2
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Halogen III Classic is,lightweight, comfortable and durable....
... InterGro DBM putty is a product ... trusted names in human tissue processing, ... bone grafting technology. InterGro combines ... carrier (lecithin) to deliver a unique ...
... The UrinQuick Urine Chemistry Analyzer is a ... of urine test strips. The UrinQuick is ... QuickVue UrinChek 10+ SG and QuickVue UrinChek ... the urine test strips by reflectance spectrophotometry. ...
The NOW Flu A test is the most frequently adopted rapid flu test on the market today. Testing could not be easier and the results are available in 15 minutes. Now you can focus on the results and tre...
Medicine Products: