Navigation Links
Stress Produces PTSD-like Symptoms in Rats

Researchers at the University of South Florida and the James A. Haley Veterans’ Hospital in Tampa have developed new ways of assessing Post-Traumatic Stress Disorder// (PTSD). These new studies show that strong, purely psychological stress produces behavioral symptoms in animal models similar to those commonly observed in people diagnosed with PTSD.

The investigators found that test rats exposed to two intense periods of stress, in conjunction with daily social stress, exhibited increased anxiety, heightened cardiovascular activity and impaired memory.

Phillip Zoladz, a USF doctoral student in psychology, conducted the research under the guidance of David Diamond, a research scientist with the Tampa VA and a professor of psychology and pharmacology at USF.

“Rats were exposed to a cat for one hour,” Zoladz said. “No physical harm came to the rats because of a barrier between the rats and cat.”

Diamond and Zoladz reasoned that because rats have a powerful instinctual fear of cats, the inability of the rats to escape from the cat would be traumatic, and that the experience would be analogous to the terror that people feel in life-threatening situations.

The rats were forced to “relive” their traumatic experience when they were unexpectedly exposed to the cat a second time, 10 days after the first exposure. Researchers also took into account the finding that a lack of social support can increase the likelihood that traumatized people will develop PTSD. The rats were housed with different cage mates on a daily basis to disrupt their social behaviors, followed by behavioral testing three weeks after the second exposure to cats.

People who experience horrific, life-threatening trauma, such as when soldiers are exposed to wartime combat, are at a substantial risk for developing post-traumatic stress disorder (PTSD). PTSD victims typically suffer from post-trauma distress because they relive their trauma through frequent flashback memories of the experience.

The USF and VA investigators suggested that this research can serve as a tool to develop pharmacological treatments which may alleviate the symptoms of PTSD in people.

“A substantial number of troops returning from the war in Iraq have been diagnosed with PTSD, according to the latest studies conducted by the U.S. Army,” said Diamond. “As a result, there’s an urgent need for research into the biological basis of PTSD to facilitate the development of treatments for this disorder.”

Just as veterans of combat with PTSD have heightened anxiety that may persist long after they return to civilian life, rats displayed high levels of anxiety, an exaggerated response to being startled, and increased blood pressure long after they were exposed to the cat, explained Diamond. The cat-exposed rats also exhibited PTSD-like behavioral responses when they were given yohimbine, a drug that causes panic in people with PTSD. Importantly, the stressed rats exhibited profound memory deficits, which indicates they had impaired functioning of the hippocampus, a brain structure which is necessary for learning and memory and shows impaired functioning in people with PTSD.

“The animal model of PTSD is unique because it utilizes purely psychological forms of stress to produce long-lasting PTSD-like symptoms in rats,” said Zoladz. “An advantage of this animal model of PTSD is that it will enable researchers to examine mechanisms in the brain that may be responsible for the pathological effects of traumatic stress on people.”

Source-ewswise
SRM
'"/>




Related medicine news :

1. Stress reduces your immunity- startling but true!!!!!
2. Stress can make you overweight
3. Stress response increases suicide risk
4. Stress triggers acne
5. Stress make acne worse
6. Stress may Worsen Acne
7. Stress can Trigger Heart Problems
8. The Best Way To Decrease Post-Mammogram Stress
9. Education Levels Found To Predict Stress
10. The Harmful Effects Of Stress in Young Adults
11. Diabetics To Seek Mental Counseling To Cope With Stress
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... (PRWEB) , ... February 12, ... ... Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the ... partnership will recruit top students from U.S. universities who will draw from ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American ... held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across ... therapy products in action, learn more about their chosen field and network with their ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... PA (PRWEB) , ... February 12, 2016 , ... ... families of the Pittsburgh metro area, celebrates the beginning of the latest charity ... children develop social skills through art. Donations to this worthy cause are currently ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Ambulances announces its first delivery in the state of ... Emergency Medical Services (EMS) consisting of four vehicles: three ... Emergency Vehicles in Lecanto, FL , USA, ... the latest in Demers, ongoing expansion of sales.  ... --> Benoit LaFortune , Executive Vice President at Demers. ...
(Date:2/12/2016)... -- Memorial Hermann Health System has teamed up with Houston ... a one-of-a-kind experience to pediatric patients at Children,s ... 360-degree video and Google Cardboard, Howard was able to ... the patients and their families an unexpected, and energetically ... video . Memorial Hermann IRONMAN Sports ...
(Date:2/12/2016)... , Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... announced the Company will ring the Nasdaq Closing Bell ... New York at 4:00 p.m. ET on ... Aralez. Adrian Adams , will perform ... 3:50 to 4:00 p.m. ET.  A live webcast will ...
Breaking Medicine Technology: