Navigation Links
Sticky Proteins Provide New Insight Into Drug Action

How drugs such as adrenalin do primarily one thing – in this case, increase the heart rate – now makes more sense to scientists.//

“Any time you get a sudden jolt, adrenaline (a.k.a. epinephrine) is why your heart rate goes up,” says Dr. Nevin A. Lambert, a biophysicist at the Medical College of Georgia. “If your heart is about to stop and the doctor administers epinephrine, that is what he or she is trying to do.”

New research, to be published in the Nov. 21 print issue of Proceedings of the National Academy of Sciences and already available online in Early Edition, may help explain how cells respond correctly to epinephrine.

Most drugs never get inside cells; they interact with external receptors that activate G proteins roaming inside cells. “If you are going to change the way the cell works, you have to transduce a signal from outside a cell inside,” says Dr. Lambert. “It’s like a relay. G proteins interact with receptors; they run into them, they collide with them. The receptor itself does not do anything other than turn on these G proteins.”

There are only four classes of G proteins, but cells contain thousands of copies of them which interact with hundreds of surface receptors. Each G protein is actually three protein subunits stuck together: alpha, beta and gamma.

Textbooks have long said that once G proteins are activated, the alpha protein splits from the beta and gamma subunits, which are irrevocably stuck together as a beta-gamma pair. Each half of the now dissociated G protein can cause the cell to do something different. “Sometimes they help each other out; sometimes they work at cross purposes,” says Dr. Lambert.

With epinephrine, that should mean the alpha subunit enables production of cyclic AMP, which increases the heart rate, while the beta-gamma pair should activate ion channels, making cells less electrically excitable and decreasing the heart rate.

However, it ha
'"/>




Page: 1 2 3

Related medicine news :

1. Levels Of Blood Proteins May Help Heart Disease Care
2. Cholesterol can be lowered using combination of Soy Proteins and Sterols
3. Neurological Disorders Overcome By Proteins
4. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
5. NR2B Proteins Lead To Chronic Pain
6. Methyl-DNA binding Proteins To Fight Cancer
7. Ape Humans? Alterations in Proteins Affects Genes.
8. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
9. Blood Clotting Disorders Linked To Three Proteins
10. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sticky Proteins Provide New Insight Into Drug Action

(Date:1/22/2015)... January 22, 2015 Blue Cross and Blue ... who exemplify what it means to “Live Fearless.” ... people to share their stories about how they or someone ... inspired others by living in the moment. By telling these ...
(Date:1/22/2015)... A new white paper by The Beryl Institute ... long-term care environment as well as provides recommendations for ... “The Power of Person-Centeredness in Long-Term Care: A View ... patient, resident and family experience in long-term care and ...
(Date:1/22/2015)... has released a new blog post presenting the basic features ... Purchasing an accidental death and dismemberment rider for a car ... provides benefits if the insured dies in an accident. Accidental ... life insurance. , AD&D is not expensive and can ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
(Date:1/22/2015)... January 22, 2015 EBSCO Information Services ... are expanding their relationship in an effort to further promote ... world. While EBSCO has long made AMA journals available via ... agent for The JAMA Network. , Long known ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... Blood-lead Tests to Pregnant Women and Young Children , ... today reminded Pennsylvania parents to test young children for ... Week, Oct. 18-24. , "Parents and caregivers need ... tested for lead poisoning," said Secretary of Health Everette ...
... Contrary to what was previously assumed, overweight is not increasing ... of the Faculty of Mathematics, Computer Science, and Natural Sciences ... and other results in the current issue of Deutsches ... 641𔃆)., Most Germans are overweight, with a body mass index ...
... (HAART) to treat HIV-1 infection are less likely than ... through breastfeeding, according to a new study. The findings, ... The Journal of Infectious Diseases , suggest HAART ... eligible mothers in areas with limited resources, such as ...
... ... keeps students informed to combat flu , ... Victoria, BC (PRWEB) October 16, 2009 -- While most Canadians ... still a very real health concern. That’s why University Canada West is keeping its ...
... cost for sugary drinks haven,t slowed obesity epidemic, study finds ... taxes and levies on soft drinks are slowing consumption, but ... States, researchers say. , In an analysis of 16 years ... soft drink taxation affected body mass index, researchers found that ...
... Medifast, Inc. (NYSE: MED ), a provider of leading ... one of "America,s 200 Best Small Companies" by Forbes magazine. ... has recognized Medifast, advancing to number 16 on the list ... the article Forbes states, "Our list of the 200 Best ...
Cached Medicine News:Health News:Pennsylvania Observes National Lead Poisoning Prevention Week 2Health News:Maternal HIV-1 treatment protects against transmission to newborns 2Health News:Schools Still on Alert for H1N1 Outbreaks 2Health News:Soda Taxes Not Making a Dent in U.S. Waistlines 2Health News:Medifast, Inc. Named by Forbes as One of 'America's 200 Best Small Companies' 2Health News:Medifast, Inc. Named by Forbes as One of 'America's 200 Best Small Companies' 3
(Date:1/23/2015)... analysis of Centers for Medicare and Medicaid Services, (CMS) ... percent of seniors chose lower-cost preferred pharmacy plans that ... The findings were released by Drug Channels . ... of Medicare Part D," said Pharmaceutical Care Management Association ...
(Date:1/23/2015)... YORK , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ... board of directors of Advaxis, Inc. ("Advaxis" or the ... board has breached its fiduciary duties to shareholders. ... on an investing website reporting that Advaxis had misrepresented ...
(Date:1/23/2015)... Biotechnology Holdings, Inc. (OTCQB: LIXT), announced that the number of ... compound, LB‑100, is being conducted, has been expanded from 1 ... M.D., the founder and President of Lixte, said that, "the ... site. Accrual of patients, however, was slower than projected. The ...
Breaking Medicine Technology:New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3
... WASHINGTON, June 15, 2011 A new ad campaign launched ... country have in finding savings for their state,s Medicaid program: ... drugstores. States and the federal government could save $33 ... overpayments and modernizing pharmacy benefits to be more like those ...
... 2011 MedNet Solutions, a global life sciences technology ... pleased to announce that MedNet will be showcasing its ... Drug Information Association (DIA) Annual Meeting in Chicago, IL ... the commercial release of iMedNet EDC earlier this year, ...
Cached Medicine Technology:The Medicaid Choice: Cut Benefits for Patients or Overpayments to Independent Drugstores 2MedNet Solutions to Showcase Its Complete Suite of eClinical Solutions at the 47th DIA Annual Meeting 2
... new highly sensitive and specific second-generation peptide-based ... on the detection of autoantibodies against the ... residues in human serum or plasma. Enabling ... Anti-CCP assay provides an additional tool in ...
Latex agglutination inhibition slide test for the qualitative detection of hCG in urine....
Color-enhanced slide test for the rapid qualitative and semi-quantitative detection of antibodies to streptococcal extracellular antigens in serum, plasma and peripheral blood....
Latex agglutination slide test for the qualitative and quantitative detection of rubella virus antibody in serum....
Medicine Products: