Navigation Links
Steroid Treatment after head injury may be fatal

According to a report from Lancet, Patients with head injury who were treated with methylprednisolone had a significantly increased risk of death within //the following 2 weeks compared with untreated group of patients.

"Our early results show that corticosteroids should not be used routinely to treat head injury, whatever the severity," Dr. Ian Roberts. He is clinical coordinator of the CRASH (corticosteroid randomization after significant head injury) trial. In 1997, a systematic review suggested the risk of death could be reduced by up to 2% by treating head injury victims with steroids, the CRASH trial collaborators note. However, the 95% confidence interval ranged between 6% fewer to 2% more deaths.

CRASH was supposed to enrol 20,000 patients with Glasgow coma score of 14 or lower within 8 hours of head injury. However after studying 10,008 patients in 239 hospitals from 49 countries the trail found 21% mortality rate within 2 weeks for those treated with the 48-hour methylprednisolone infusion, versus 18% among those allocated placebo (relative risk 1.18, p = 0.0001).

"The relative increase in deaths due to corticosteroids did not differ by injury severity (p = 0.22) or time since injury (p = 0.05)," the authors note.

"By clearly refuting a mortality benefit from corticosteroids in head injury, the CRASH trial results should protect many thousands of patients from any increased risk of death associated with these drugs," they add. These findings could have similar implications for use of corticosteroids in spinal cord injury.

The lesson learnt from CRASH according to Dr. Stefan Sauerland, at the University of Cologne, and Dr. Marc Maegele at the University of Witten-Herdecke, in Germany, is that "we should avoid trusting in underpowered clinical trials with surrogate rather than clinical endpoints, and transferring evidence from one disease to another."


'"/>




Page: 1

Related medicine news :

1. Inhaled Steroids Safe & Effective for Children with Asthma
2. Mislabeled Body-building Steroid Supplements
3. Steroid Treatment for Wheezing Questioned
4. Steroid-Free Liver Transplants
5. The Use Of Steroids for Dizziness Questioned
6. Biofeedback Found To Reduce Steroid Dependence In Asthmatics
7. The Link Between High-dose Steroid Use And Heart Disease Questioned
8. The Use Of Oral Steroids For Muscular Dystrophy Questioned
9. No Steroids for Traumatic Brain Injury
10. Steroids Effective For Treating Carpel Tunnel Syndrome
11. FDA to bring about changes in Marketed Non-Steroidal Anti-Inflammatory Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
Breaking Medicine Technology: