Navigation Links
Stem cells offer hope for muscular dystrophy

Italian researchers said on Thursday they were combining two new and experimental therapies -- using stem cells and gene therapy -- to try to treat muscular dystrophy. Their early work has shown some success in mice but they warned any real progress is years away.
Writing in the journal Science, the team lead by Dr. Giulio Cossu of the Stem Cell Research Institute in Milan and the University of Rome said certain stem cells //had been coaxed into strengthening the muscles of mice with muscular dystrophy.

There are nine forms of muscular dystrophy, which affect 300,000 people in the United States alone. This group of genetic diseases is marked by progressive weakness and degeneration of the muscles that control movement, as well as, sometimes, the heart and other organs. There is no treatment or cure.

Cossu and colleagues worked with cells called mesoangioblasts, a type of stem cell. Stem cells are master cells that can produce a whole range of cells and tissues. Mesoangioblasts are called "adult" stem cells although this particular kind has so far been found only in fetuses.

The researchers injected mesoangioblasts into the arteries of mice genetically engineered to lack the alpha sarcoglycan gene -- in effect giving the mice a form of MD. These mesoangioblasts turned up downstream. The team then genetically engineered the stem cells, putting in healthy versions of alpha sarcoglycan gene, and injected these into the mice. Three months later, they found healthy alpha sarcoglycan proteins in the muscles of the treated mice. "The muscle cells of a dystrophied mouse are extremely weak, but a cured mouse recovered almost entirely all its strength," said Roberto Bottinelli from the University of Pavia, who worked on the study.

The experiment proves a theory but some real-world stumbling blocks remain. For instance, the approach would work best if a patient's own mesoangioblasts were used, but these cells have so far only been isolated from fetuses. "I'm convinced this is an important result, but this is still not the therapy, for the mice or for patients," Cossu said.
'"/>




Related medicine news :

1. Action of nerve cells
2. Therapy for stopping the spread of cancer cells
3. Hydroxyurea derivatives kill colon cancer cells
4. Creating brain cells from bone marrow
5. A Chinese herb kills cancer cells
6. Immune cells halt round in space
7. Transforming stem cells to lung cells
8. Changing stem cells to liver cells
9. Enzyme stimulates growth of adult stem cells
10. Stem cells aid to cure brain cancer
11. Brain cells protected by new compounds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
Breaking Medicine Technology: