Navigation Links
Stem cells offer hope for muscular dystrophy

Italian researchers said on Thursday they were combining two new and experimental therapies -- using stem cells and gene therapy -- to try to treat muscular dystrophy. Their early work has shown some success in mice but they warned any real progress is years away.
Writing in the journal Science, the team lead by Dr. Giulio Cossu of the Stem Cell Research Institute in Milan and the University of Rome said certain stem cells //had been coaxed into strengthening the muscles of mice with muscular dystrophy.

There are nine forms of muscular dystrophy, which affect 300,000 people in the United States alone. This group of genetic diseases is marked by progressive weakness and degeneration of the muscles that control movement, as well as, sometimes, the heart and other organs. There is no treatment or cure.

Cossu and colleagues worked with cells called mesoangioblasts, a type of stem cell. Stem cells are master cells that can produce a whole range of cells and tissues. Mesoangioblasts are called "adult" stem cells although this particular kind has so far been found only in fetuses.

The researchers injected mesoangioblasts into the arteries of mice genetically engineered to lack the alpha sarcoglycan gene -- in effect giving the mice a form of MD. These mesoangioblasts turned up downstream. The team then genetically engineered the stem cells, putting in healthy versions of alpha sarcoglycan gene, and injected these into the mice. Three months later, they found healthy alpha sarcoglycan proteins in the muscles of the treated mice. "The muscle cells of a dystrophied mouse are extremely weak, but a cured mouse recovered almost entirely all its strength," said Roberto Bottinelli from the University of Pavia, who worked on the study.

The experiment proves a theory but some real-world stumbling blocks remain. For instance, the approach would work best if a patient's own mesoangioblasts were used, but these cells have so far only been isolated from fetuses. "I'm convinced this is an important result, but this is still not the therapy, for the mice or for patients," Cossu said.

Related medicine news :

1. Action of nerve cells
2. Therapy for stopping the spread of cancer cells
3. Hydroxyurea derivatives kill colon cancer cells
4. Creating brain cells from bone marrow
5. A Chinese herb kills cancer cells
6. Immune cells halt round in space
7. Transforming stem cells to lung cells
8. Changing stem cells to liver cells
9. Enzyme stimulates growth of adult stem cells
10. Stem cells aid to cure brain cancer
11. Brain cells protected by new compounds
Post Your Comments:

(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... out by the University of Toronto and the University of British Columbia suggested that ... for head injuries. The article explains that part of the reason for the controversial ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at ... people age, more care is needed, especially with Alzheimer’s, dementia and other cognitive ... being overworked. The forgotten part of this equation: 80 percent of medical care ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ... , ... Lizzie’s Lice Pickers just announced a special promotion that will run ... purchase of lice treatment product. In addition, customers will receive a complimentary head Check ... lice is a sure way to ruin the holidays, so we encourage all of ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a set of ... With ProSidebar: Fasion, video editors can easily add an informative sidebar to any FCPX ... Utilize presets featuring self-animating drop zones, lines, bars, and text with the ease ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... --> ... att använda SyMRI för att hitta optimal ... med multipel skleros (MS) eller hjärntumörmetastaser och ... för att kunna använda SyMRI Research Edition ... kan man generera flera konstrastbilder från en ...
Breaking Medicine Technology: