( A new study has highlighted that patien...)Stem cell transplant recipients face significant risk of second cancer,Health

A new study has highlighted that patients who receive a hematopoietic stem cell transplant (HSCT), face a considerable risk of developing a second cancer, especially// if they are older during the time of the transplant or have received stem cells from a female donor.

A peer-reviewed journal of the American Cancer Society, the study shows that within a decade of an allogeneic HSCT, the comparative risk of a second cancer is twice that of the general population. In addition, cancer risk almost quadruples for patients who were over 40 years old at the time of transplant or for patients who received stem cells from a female donor.

Myeloablative, allogeneic HSCT is an effective standard therapy for specific life-threatening diseases, such as leukemia or myelodysplastic syndrome, for which blood cell lineages (which originate principally in the bone marrow and circulate in the blood) are abnormal. Destroying the patient's own unhealthy stem cells in the bone marrow and replacing them with a compatible donor's stem cells offers the chance of cure for a disease that otherwise has a high mortality rate with non-transplant therapies. While the procedure can be lifesaving, it is associated with serious short-term adverse effects, such as mucostitis, infections, and liver vascular obstruction as well as the potential long-term complication of developing of a second, usually solid cancer.

To estimate the risk and identify risk factors associated with this outcome, Genevieve Gallagher, M.D. and Donna L. Forrest, M.D. of the BC Cancer Agency and the University of British Columbia, retrospectively reviewed the medical records of 926 patients treated with myeloablative stem cell transplants over an 18-year period.

They found that at their institution the 10-year incidence of second cancers in these patients was 3.1 percent. When nonmelanoma skin cancer and carcinoma in situ of the cervix were excluded, incidence was 2.3 percent. That
'"/>




Page: 1 2
Related medicine news :

1. Infant receives first bloodless liver transplant
2. Liver donors can thrive after transplant
3. ATG useful in transplant patients as substitute for steroids
4. Stem cell transplantation of eye
5. Woman gets cancer from transplanted kidney
6. Parasite infections linked to organ transplants
7. Vitamins enhances recuperation of organ transplant patients
8. Vitamins suppress artery injury after transplant
9. Liver transplant oversight urged
10. Cell transplants used to fend off Parkinsons symptoms
11. Stem cell transplantation of eye