Navigation Links
Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours

Boffins have developed a new gene therapy by using 'suicide genes' derived from mesenchymal stem cells taken from human fat tissue, which hunt for and kill cancerous tumours.

The study was conducted by a team of researchers led by Cestmir Altaner at the Cancer Research Institute of the Slovak Academy of Sciences in Bratislava.

As part of the study to find a less toxic method than chemotherapy to treat colon cancer, researchers extracted the mesenchymal stem cells from human fat tissue, and after expanding their number in the lab, used a retrovirus vector to insert the gene cytosine deaminase into the cell.

The gene can convert a less toxic drug, 5-fluorocytosine (5-FC), used in chemotherapy, to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumour, producing a lethal by-stander effect.

Researchers first injected the engineered mesenchymal stem cells, then 5-FC in nude mice, animals with an inhibited immune system, engrafted with human colon cancer.

The study found that tumour growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

"The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments," Altaner said.

Researchers suggested that mesenchymal stem cells 'see' a tumour as a damaged organ and migrate to it, and so it might be used as a 'vehicle' for treatment that can find both primary tumours and small metastases.

The findings of the study were published in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.


'"/>




Page: 1

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/18/2017)... Massachusetts (PRWEB) , ... February 17, 2017 , ... ... the leading source of disruptive innovation in the industry, according to the recent ... Reports are based on surveys of the NEJM Catalyst Insights Council, a qualified ...
(Date:2/18/2017)... ... February 18, 2017 , ... ... Use Pixel Film Studios ’ ProParagraph Fashion Volume 2 for all multi-line ... other applications. Users can pick and choose from hand-crafted trend-setting designs with ...
(Date:2/17/2017)... ... February 17, 2017 , ... The Alliance ... change designed to further positively impact the health and wellness of our community ... considered it our duty to seriously consider releasing our assets beyond our 5% ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering ... Francis' goals for each and every seminar, session and class she offers. ... five different brainwave tools which help energize creativity, focus mental functions, enhance athletic ...
(Date:2/17/2017)... ... , ... Program will serve more than 5,000 kids in ... Foundation announced today that they have awarded nine grants to expand the Foundation’s ... mentoring program, teaches kids the fundamentals of soccer while striving to help them ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017 ... health offerings at the  2017 HIMSS ... PHG,AEX: PHIA), a global leader ... broad range of population health ... health solutions, fully integrated in a highly ...
(Date:2/16/2017)... , Feb. 16, 2017 Research and ... for Emerging Medical Device Technologies" report to their offering. ... ... open procedures, general instruments, non-drug coated implantables, large endoscopes, needle ... in use over the last two to three decades for ...
(Date:2/16/2017)... The Lockwood Group (Lockwood), a medical communications agency, ... in Connecticut list by the ... a row that Lockwood has been in the top 10, ... spot in 2017. The award recognizes companies that have been ... determined through a survey conducted by The Best Companies Group ...
Breaking Medicine Technology: