Navigation Links
Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours

Boffins have developed a new gene therapy by using 'suicide genes' derived from mesenchymal stem cells taken from human fat tissue, which hunt for and kill cancerous tumours.

The study was conducted by a team of researchers led by Cestmir Altaner at the Cancer Research Institute of the Slovak Academy of Sciences in Bratislava.

As part of the study to find a less toxic method than chemotherapy to treat colon cancer, researchers extracted the mesenchymal stem cells from human fat tissue, and after expanding their number in the lab, used a retrovirus vector to insert the gene cytosine deaminase into the cell.

The gene can convert a less toxic drug, 5-fluorocytosine (5-FC), used in chemotherapy, to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumour, producing a lethal by-stander effect.

Researchers first injected the engineered mesenchymal stem cells, then 5-FC in nude mice, animals with an inhibited immune system, engrafted with human colon cancer.

The study found that tumour growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

"The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments," Altaner said.

Researchers suggested that mesenchymal stem cells 'see' a tumour as a damaged organ and migrate to it, and so it might be used as a 'vehicle' for treatment that can find both primary tumours and small metastases.

The findings of the study were published in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.


'"/>




Page: 1

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
Breaking Medicine Technology: