Navigation Links
Stem Cells from Human Fat Tissue to Hunt for and Kill Cancerous Tumours

Boffins have developed a new gene therapy by using 'suicide genes' derived from mesenchymal stem cells taken from human fat tissue, which hunt for and kill cancerous tumours.

The study was conducted by a team of researchers led by Cestmir Altaner at the Cancer Research Institute of the Slovak Academy of Sciences in Bratislava.

As part of the study to find a less toxic method than chemotherapy to treat colon cancer, researchers extracted the mesenchymal stem cells from human fat tissue, and after expanding their number in the lab, used a retrovirus vector to insert the gene cytosine deaminase into the cell.

The gene can convert a less toxic drug, 5-fluorocytosine (5-FC), used in chemotherapy, to 5-FU inside the stem cells, and the chemotherapy can then seep out into the tumour, producing a lethal by-stander effect.

Researchers first injected the engineered mesenchymal stem cells, then 5-FC in nude mice, animals with an inhibited immune system, engrafted with human colon cancer.

The study found that tumour growth was inhibited by up to 68.5 percent in the animals, and none of the mice exhibited any signs of toxic side effects.

"The procedure was quite effective even though we applied the stem cells just once. Obviously, repeated treatment will increase the efficacy, as would using this strategy in combination with other treatments," Altaner said.

Researchers suggested that mesenchymal stem cells 'see' a tumour as a damaged organ and migrate to it, and so it might be used as a 'vehicle' for treatment that can find both primary tumours and small metastases.

The findings of the study were published in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.


'"/>




Page: 1

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: