Navigation Links
Stem Cells Research in Parkinsons Disease

A University of South Florida neuroscientist reports that the cutting-edge research study of human stem cells in primates with Parkinsons disease is compelling on several fronts particularly how the transplanted cells did their job of easing disease symptoms.

Paul R. Sanberg, DSc, PhD, Distinguished Professor of Neurosurgery and Director of the Center for Aging and Brain Repair at USF Health, wrote the commentary Neural Stem Cells for Parkinsons Disease: To Protect and Repair published July 9 in the Early Edition online version of journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

That NIH-funded study showed that only a small number of stem cells turned into dopamine-producing cells not enough to improve the primates function by replacing missing neurons. Instead, some stem cells turned into astrocytes, a supportive brain cell that produces neuron-nourishing chemicals.

The researchers also identified in the brains of the primate recipients a significant amount of dopamine-producing neurons that were not derived from stem cells. The results suggest that stem cells may actually trigger the brains own self-repair mechanisms by pumping out molecules that boost nerve survival and blood vessel development and decrease neural degeneration.

We at the Center for Aging and Brain Repair at USF Health have been arguing, for some time now, that stem cells are important for brain repair because they provide growth factors and because they send signals to the brain to help it repair itself, Dr. Sanberg said.

This study in primates showed the same effects that the stem cells are there to act as facilators of repair versus the original hypothesis that stem cells are transplanted to merely replace an injured cell.

Dr. Sanberg said the study has relevance to all audiences. This was one of the first studies to look at stem cells in primates with Parkinsons disease. Its the first step in translating that research, he said.

We hear about new sources of stem cells monthly, but how we take those cells and treat disease is going to be a significant amount of translational work. This is one of the first studies that starts that process looking at primates before going into people with Parkinsons disease.

While the transplanted cells appeared not to form tumors following transplant, Dr. Sanberg said the translational research in primates raises questions that need to be addressed before moving to human trials, including determining the most effective cell dosing and brain sites to target.

Pending further preclinical studies, he writes in the commentary, the results so far from the current study are supportive for developing a safe and effective stem cell treatment for Parkinsons disease.

Dr. Sanbergs commentary and the study it highlights will also be published in the magazine edition of PNAS, a prestigious publication with a global audience. PNAS has been a resource for multidisciplinary research since 1914. Its online edition, where Dr. Sanbergs commentary appears this week, receives nearly 6 million e-visitor hits per month.

Content includes research reports, commentaries, reviews, perspectives, colloquium papers, and actions of the Academy. Coverage in PNAS spans the biological, physical, and social sciences.


'"/>




Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology: