Navigation Links
Stem Cells Provide New Tool for Studying Disease and Identifying ALS Drugs

Results of two studies funded by Project A.L.S. and appearing in today's advance online publication of Nature Neuroscience //demonstrate that embryonic stem cells may provide a new tool for studying disease mechanisms and for identifying drugs to slow ALS, also known as Lou Gehrig's disease.

Both studies were completed by researchers participating in an ongoing collaboration with the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, the world's first and only privately funded laboratory focused exclusively on stem cells and ALS.

The complementary studies, led by Kevin Eggan, of the Harvard Stem Cell Institute, and Serge Przedborski, of Columbia University Medical Center compellingly demonstrate that embryonic stem cells can be used to create an in vitro model of ALS, a fatal neurodegenerative disease that selectively destroys motor neurons, messenger cells responsible for virtually all voluntary movement.

Until now, scientists have not known whether motor neurons in ALS die because of a problem within the cell—or from outside the cell. The study by Eggan's group describes successful use of a novel embryonic stem cell-based model for ALS that will help scientists to answer this and other questions. Utilizing this model both Eggan and Przedborski's groups observed that non-neuronal cells called astrocytes may have a toxic effect on motor neurons in ALS.

The Columbia study provides further evidence that astrocytes are toxic to motor neurons in ALS. The Columbia team's discovery of astrocyte-toxic mediators provides not only an insight into how the damage associated with ALS occurs, and a potential biomarker for early diagnosis of the disease — but also provides a target for potential new therapies aimed at slowing motor neuron degeneration in ALS.

"That's what happens when scientists from major institutions work together toward shared goals. Project A.L.S. prides itself on building productive re search teams from elegant parts," said Valerie Estess, director of research for Project A.L.S.

"The remarkable interest, curiosity and open-mindedness for new and promising lines of research is emblematic of Project A.L.S.," added Serge Przedborski, Page and William Black Professor of Neurology, at Columbia.


Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:

(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners is ... sequencing and genomics experience, as Vice President of North American Capital Sales at ... for leading the sales team in the commercialization of the HTG EdgeSeq system and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: