Navigation Links
Stem Cells In Brain Have Potential For Sensing Damage And To Repair

Adult stem cells have the ability to trace damaged tissue in the brain and repair it accordingly, says a US led study on mice.//

This finding is of great interest because the same type of cells are also present in the human brain, and this knowledge can be put to therapeutic use in future, to treat brain tissues damaged by disorders such as traumatic injury.

Dr. Chay Kuo, a University of California-San Francisco postdoctoral fellow in the laboratory of senior investigator Yuh-Nung Jan, led the study.

'The results were very surprising,' said Kuo. 'They show that neural stem cells in mice have the ability to sense damage in their environment that leads to their subsequent proliferation to help restore local tissue integrity.'

In this study, mice, genetically engineered to have holes in a region of their brain, recovered due to the work of stem cells in the area.

The next step is to determine how these stem cells sense damage and then begin to work on the injured tissue. "If we can figure out how this happens, and determine that it occurs in human neural stem cells," says Chay T. Kuo, a researcher in Jan's lab, "we may be able to increase the effect and harness it for therapeutic use."

This study was conducted to throw light upon the molecular programs that control neural stem cells in the postnatal mouse and how the neural stem cells respond to tissue damage.

Kuo and his colleagues genetically engineered neural stem cells and ependymal cells in the SVZ of newborn mice in such a way that they lacked two key proteins, named Numb and Numblike.

A postnatal mouse brains autopsy conducted 7 and 14 days after the genetic modification revealed that absence of proteins Numb and Numblike led to severe brain ventricle enlargement.

To the astonishment of the researchers, the damage to the left ventricular wall was substantially repaired when these sick mice were examined six weeks later. This was suspected to be due to the limitation of the technique-some neural stem cells escaped gene deletion, thus allowing the Numb protein they synthesized to remain intact and some neural stem cells had continued to function.

As a response to the damage sensed in the region, these cells had, mediated and rebuilt the ventricular wall lining and succeeded in establishing a modified neural stem cell environment.

The scientists have still not deciphered the precise mechanism by which the stem cells carried out the response.

"The holes that had formed in the brain ventricular wall had largely been repaired. These adolescent mice looked quite good. The finding shows that the brain has the ability to repair itself and that it is more plastic than previously appreciated," said Dr Jan.
PRI
'"/>




Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... LEXINGTON, Mass. , June 24, 2016   ... specialty pharmaceutical company developing innovative inhaled drugs, announced today ... when Russell Investments reconstituted its comprehensive set ... 2016. "This is an important milestone for ... "It will increase shareholder awareness of our progress in ...
Breaking Medicine Technology: