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Stanford Researchers Identify A Gene Causing Downs Syndrome

responsible for early onset Alzheimer's disease, having three copies of the gene could somehow have a harmful effect on the brain.

Professor Mobley said, “There are all of these genes on chromosome 21, and undoubtedly all of them contribute in some way to these changes that you see in people with Down's syndrome. The challenge is to say can you find specific abnormalities linked to specific genes.” Stating that as the next step, the mechanism for this process should be found, and then it should be seen if there is any way by which these manifestations by the gene can be ‘turned down’, He said, “If we can decrease the expression of this gene, we may be able to provide something more than supportive care to people with Down's syndrome.”

Professor Elizabeth Fisher, of the Institute Neurology, UCL, said, “This is a very interesting paper. This may be some way towards an explanation of why people with Down's syndrome develop the hallmark brain signs of Alzheimer's disease”


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