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Standard Therapy More Effective in Common Fertility Disorder

te more cycles of ovulation than clomiphene alone, these extra cycles might result in a higher number of eggs that are not capable of fertilization or development.

“Our results show that you can’t use ovulation as a surrogate for pregnancy,” Dr. Legro said “An ovulation on clomiphene treatment is twice as likely to result in pregnancy as an ovulation on metformin, thus all ovulations are not alike.”

The researchers also reported that women in the clomiphene groups had more occurrences of multiple pregnancy: 6.4 percent for the clomiphene-only group, 3.3 percent for the combination group and 0 percent for the metformin group. Clomiphene is known to stimulate the release of more than one egg at a time. Dr. Legro noted that the rate of multiple pregnancy seen in the study for women treated with clomphene was less than the multiple pregnancy rate after in vitro fertilization, which averages about 33 percent.

The study authors noted that while metformin alone did not improve the chances for pregnancy, it was useful for lowering the high blood testosterone levels that occur with PCOS.

“In summary, our study supports the use of clomiphene citrate alone as first-line therapy for infertility in women with PCOS,” the study authors wrote.

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