Navigation Links
Sperm stem cells could be an alternative to embryonic stem cells in future

Stem cells are one of the fascinating areas of biology today, with new experiments continually replacing our existing knowledge about the potential applications of stem cells.

Scientists have now been successful in manipulating rat // sperm cells to behave like embryonic stem cells, which are capable of giving rise to various cell lineages such as a nerve cell, blood cell or a skin cell. In simple terms, the issue is all about making sperm cells pluripotent. The use of these cells in the treatment of diabetes and Parkinson’s disease is still in infancy due to unresolved ethical issues stemming from the source of these cells - human embryos or mouse cells.

Ordinarily, when germ stem cells divide into two cells, one "daughter" cell differentiates to become a sperm while the other remains a stem cell. The study represents a remarkable breakthrough as the fate of the male germ cells that give rise to sperms have been altered. Surprisingly, the stem cells even retained their capacity to transform into sperms after they were transplanted back into rat testes.

One of the breakthroughs in this study was the development of a new culture medium to grow the cells and the incorporation of a tag, the green fluorescent protein to help enable easy identification of germ cells from a mixture.

The findings of the present study have valuable clinical implications. It can pave way for the development of male contraceptives and a refinement in the animal models used in the study of infertility. It can even serve as an ideal alternative to embryonic stem cells.

"The ability to manipulate male germ-line stem cells and get them to grow and self-renew is a major step," said Dr. Garbers, a Howard Hughes Medical Institute investigator at UT Southwestern.

The researchers have now focused their attention towards genetic manipulation of the derived rat cells so that it can be extrapolated to produce ‘knock out mice’ that ca n be used in studying health and behavioral effects related to the knocked off genes.

The next step is to determine whether human male germ-line stem cells can also be conferred immortality under artificial laboratory conditions. Perhaps, someday, it might be possible to correct genetic defects in humans such as cystic fibrosis in the near future
'"/>




Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. Now you can identify Sperm and Egg donors
3. Elevated Ozone Levels Hurt Sperm Count
4. Sperm washing helps couples
5. The Falling Sperm Count In Men
6. Anonymous Sperm Donor Traced On Internet
7. Declining Rates Of Sperm Donors Over The Past 5 Years
8. Sperm Retrieval, Difficult in Klinefelter’s Syndrome Patients after 35 Year
9. Researchers Identify Role Of Protein In Sperm Hyperactivation
10. Sperms not silent in the Female reproductive Tract
11. Non-Hormonal Male Contraceptive Based on Sperm Block Underway
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... ... 27, 2017 , ... It’s no secret that aging causes ... a host of health issues, including urinary incontinence. However, results published in late ... good overall muscle strength in older women, particularly in the abdominal and pelvic ...
(Date:2/27/2017)... ... 2017 , ... Robert E. Burke, MD, PhD, had a successful career as ... life experiences could have led him down a much different path. , In his ... Perseverance and Pediatrics,” Dr. Burke shares a personal account of the tribulations he encountered ...
(Date:2/27/2017)... NEW PORT RICHEY, Fla. (PRWEB) , ... February 27, 2017 , ... ... substance use disorder, but concern for women who become dependent on opioid painkillers has ... 400% among female patients, compared to a 237% increase in fatal overdoses in male ...
(Date:2/27/2017)... Ohio (PRWEB) , ... February 27, 2017 , ... Elisa Guajardo Carothers is not your ... Life” to studying to become a nun. Now, she writes about God, when she isn’t ... “You Know BC and AD, Here is BS! (Before Satan),” she offers a comedic look ...
(Date:2/27/2017)... ... February 27, 2017 , ... This webinar ... analysis as a tool to characterize particle size distributions in the field of ... results and novel scientific findings. It describes methods of optimized and standardized sample ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017  RegeneRx Biopharmaceuticals, Inc. ... drug development company focused on tissue protection, repair ... RGN-137, GtreeBNT Co., Ltd., received a positive response ... clinical trial design for RGN-137 to treat epidermolysis ... gel that incorporates Thymosin beta 4 ("Tß4") as ...
(Date:2/27/2017)... NEW YORK , February 27, 2017 ... (PII) celebrates the pharmaceutical companies that are most successful at ... ... question: if you gave the same molecule to two different ... it? Based on systematic, objective analysis of each ...
(Date:2/27/2017)... Leading Countries, Technologies and Companies ... grow at a CAGR of 8.9% from 2016-2021 and CAGR of ... CAGR of 9.1% from 2016 to 2027. The market is estimated ... ... Read on to discover how you can exploit the future ...
Breaking Medicine Technology: