Navigation Links
Sperm Cells attracted By Ovary Scent, Even in Weakened State

A new study by scientists at Indiana University Bloomington have reported that mouse sperm cells are capable of tracking the faintest of scents. //Sperm cells were bang on target, even when ovary extracts were extremely diluted.

"Sperm are known to exhibit chemotaxis toward extracts from various female reproductive organs, but the role of chemotaxis in reproduction is not known," said IUB Associate Professor of Chemistry Stephen C. Jacobson. "The chemicals that actually attract sperm have not been identified. Systematic study of various compounds released by the female reproductive organs under various conditions might further our understanding of these processes." Understanding why, how and when sperm are attracted to ovaries may help scientists understand problems with human conception.

"Defects in sperm chemotaxis may be a cause of infertility, and consequently, sperm chemotaxis could potentially be used as a diagnostic tool to determine sperm quality or as a therapeutic procedure in male infertility," Jacobson said.

The project is a collaboration between research groups led by Jacobson and IUB Distinguished Professor of Chemistry Milos V. Novotny. Their work led to the development of a "flow-through" device, a sort of liquid treadmill for sperm cells, which allows researchers to follow the lateral movement of sperm as the cells swim through a liquid medium.

The device feeds three streams of liquid into a single chamber. Beyond the chamber, flows are split into three exit streams. Flow rate can be regulated simply by raising or lowering the height of the source medium, in this case a buffer solution. The researchers affixed a microscope and camera to the device and then recorded video of the sperm during assays.

"We combined in a microfluidic device the ability to generate a chemical gradient with transporting sperm cells to evaluate sperm chemotaxis," Jacobson said. "The use of microfluidic devices appears to be an ideal approach for precisely controlling the chemical gradient and accurately tracking chemotactic events. This combination led to greater repeatability in the experimental conditions over the course of the assays, which is currently not possible with conventional assays. These results are an important first step toward having an easy-to-use platform to rapidly evaluate and quantify chemotaxis." The researchers hope their device will help other scientists more accurately examine the chemotaxis of all types of cells. The method also eliminates the phenomenon of "trapping," which causes study results to become ambiguous.

"The ability to differentiate chemotaxis from trapping helps to determine whether sperm were attracted to the test substance or the swim velocity was reduced close to the test substance," Jacobson said. "In the latter case, the test substance may have had a negative influence on the sperm, resulting in suppression of their movement." Novotny is the Lilly Chemistry Alumni Chair in the Indiana University Bloomington Department of Chemistry, where he also directs the Institute for Pheromone Research.

Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. Now you can identify Sperm and Egg donors
3. Elevated Ozone Levels Hurt Sperm Count
4. Sperm washing helps couples
5. The Falling Sperm Count In Men
6. Anonymous Sperm Donor Traced On Internet
7. Declining Rates Of Sperm Donors Over The Past 5 Years
8. Sperm stem cells could be an alternative to embryonic stem cells in future
9. Sperm Retrieval, Difficult in Klinefelter’s Syndrome Patients after 35 Year
10. Researchers Identify Role Of Protein In Sperm Hyperactivation
11. Sperms not silent in the Female reproductive Tract
Post Your Comments:

(Date:10/12/2015)... , ... October 12, 2015 , ... Advera Health ... no charge to qualified Managed Care Organizations (MCOs) in order to provide health plans, ... into their decision making process. In addition, the DSM is also being offered to ...
(Date:10/12/2015)... ... October 12, 2015 , ... To ... announced its charitable donation to the National Breast Cancer Foundation. The National Breast ... by breast cancer through early detection, education, and support services. , The annual ...
(Date:10/12/2015)... ... ... Clara dentist , Dr. Alan Frame, shares his insight on today’s dental hygiene and the ... “I want each one of my patients to be at their optimum level of health, ... implants dentist , Dr. Frame. He mentions, "As the white paper mentions, oral health care ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... receive a Eugene Washington Engagement Award by the Patient-Centered Outcomes Research Institute (PCORI) ... the research community. , The project, entitled “Training Patients with Asthma to ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... secured a new corporate headquarters, located at 485 Madison Avenue, New York, NY ... and increased emphasis on cloud-based technology. , “Care to Care is a dynamic ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... Cell Therapy Catapult to advance development of large ... cell immunotherapy. Under the agreement, the Cell Therapy ... AST-VAC2 to support advanced clinical trials and eventual ... --> The Cell Therapy Catapult is ...
(Date:10/12/2015)... 13, 2015 the United States ... a non-clinical capacity. --> the United States ... a non-clinical capacity. --> The University of Texas MD ... the first high field (1.5 Tesla) MRI-guided linear accelerator in ... system will be operating in a non-clinical capacity. Royal ...
(Date:10/12/2015)... 2015 Given the intricacy of the ... to deliver an ophthalmic drug effectively to a specific ocular ... ocular drug delivery. These include dilution of a drug by ... conjunctiva and drug permeation issues with respect to the cornea, ... eye drops, is lost due to the aforementioned barriers. ...
Breaking Medicine Technology: