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Specific Protein is Instrumental in Myelination

elination of white matter lesions.

A lesion in white matter naturally prompts progenitor cells to replicate and migrate to the site of the lesion where they are involved in remyelination and functional repair.

Over-expression (through genetic manipulation) of epidermal growth factor receptor (EGFR) protein promotes both myelination and remyelination (creation and repair of white matter).

Over-expression (through genetic manipulation) of EGFR protein promotes functional recovery of neural fibers (demonstrated through the conduction of electrical impulses).

Reducing (through genetic manipulation) EGFR signaling decreases myelination and remyelination.

Dr. Gallos work also reconfirmed that by enhancing EGFR receptor activity on a specific population of progenitor cells (through genetic manipulation), myelination and remyelination can be enhanced.

This part of the study builds on earlier work done in collaboration with Nancy Ratner, PhD, Professor in the Division of Experimental Hematology, Cincinnati Childrens Hospital Medical Center.

web site at www.dcchildrens.com.


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