Navigation Links
Specific Protein is Instrumental in Myelination

Scientists at Childrens National Medical Center have demonstrated conclusively that a specific protein and its signaling activity are instrumental in myelination and remyelination, processes essential to the creation and repair of the brains white matter.

This groundbreaking discovery in mouse models points the way to developing treatments or interventions to enhance healthy brain development and/or brain disease repair in children and adults. The paper will be published in the August issue of Nature Neuroscience.

By understanding the fundamental mechanisms of brain development, we get closer to finding clear instructions to repairing developmental brain disorders and injuries, said Vittorio Gallo, PhD, Director, Center for Neuroscience Research, Childrens Research Institute at Childrens National Medical Center.

Dr. Gallo and colleagues study used mouse models to identify an essential protein and its signaling activity in the processes of myelination and remyelination. These processes are relevant to white matter development and repair.

When white matter is injured or defective, the essential functions of information relay are impaired. Underdeveloped white matter or white matter injuries are linked to conditions including mental retardation, cerebral palsy and multiple sclerosis.

Childrens National Medical Center is the ideal environment for complex research, said Dr. Gallo. We work collaboratively with research institutes around the world, and then we walk down the hall to confer with colleagues who are on the front line of direct clinical care.

My colleagues in clinical research and care pioneered whole body cooling, which slows down brain damage underway in compromised newborns. Our breakthrough at the level of laboratory research will soon translate to the bedsides where they care for newborns.

If we can marry whole body cooling with new approaches that boost the activity of this essential protein, we may be able to slow down injury and enhance myelination, continued Dr. Gallo.

Some day we may be able to repair brain damage and subsequent affects such as mental retardation, developmental disabilities or other disorders that result from incomplete myelination or white matter damage.

Myelination in humans begins in utero at around 5 months of gestation and continues throughout the first three years of life, but can be impaired for a number of reasons, most commonly intrauterine infection, reduced or interrupted blood flow (which carries oxygen and nutrients) to the forming infant brain, or perinatal injury.

These conditions affect up to 30 percent of preterm babies, many with severe motor and cognitive deficits, such as in patients affected by cerebral palsy.

Remyelination is a natural attempt by the brain to repair damage of the white matter; however the brain does not have the ability to completely repair itself.

Dr. Gallo and colleagues work used enhanced epidermal growth factor receptor (EGFR) protein and activity to clearly demonstrate the role that this molecule plays as a catalyst to the natural processes of proliferation and migration of progenitor cells, which are integral to white matter development and repair.

By first inserting enhanced EGFR protein and showing enhanced myelination/remyelination, and then using an EGFR protein with reduced biological activity and showing the decrease in myelination/remyelination Dr. Gallo and colleagues demonstrate that EGFR protein is an essential ingredient and that its signaling is instrumental in progenitor cell proliferation, migration, and in myelination and functional repair of white matter.

Dr. Gallos work reported in this paper specifically demonstrates the following: Progenitor cells in the peri-ventricular zone of the brain contribute to remy elination of white matter lesions.

A lesion in white matter naturally prompts progenitor cells to replicate and migrate to the site of the lesion where they are involved in remyelination and functional repair.

Over-expression (through genetic manipulation) of epidermal growth factor receptor (EGFR) protein promotes both myelination and remyelination (creation and repair of white matter).

Over-expression (through genetic manipulation) of EGFR protein promotes functional recovery of neural fibers (demonstrated through the conduction of electrical impulses).

Reducing (through genetic manipulation) EGFR signaling decreases myelination and remyelination.

Dr. Gallos work also reconfirmed that by enhancing EGFR receptor activity on a specific population of progenitor cells (through genetic manipulation), myelination and remyelination can be enhanced.

This part of the study builds on earlier work done in collaboration with Nancy Ratner, PhD, Professor in the Division of Experimental Hematology, Cincinnati Childrens Hospital Medical Center.

web site at www.dcchildrens.com.


'"/>




Related medicine news :

1. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
2. Heart Drug Also Effective In Preventing Specific Causes Of Death
3. Specific Changes In A Particular Gene Found To Increase The Risk of Alzheimer’s Diseas
4. New Race –Specific drug
5. Age-Dependent Alterations Not Specific For Alzheimers Disease
6. Developing Specific Skills Ensure Better Grades In US Kids
7. Specific Immune Mechanism against DNA viruses
8. The Publication Of Surgeon Specific Death Rates Raises Controversy
9. Timing of Food Consumption Activates Genes in Specific Brain Area
10. By Targeting Specific Germs, Hospital Hopes to Improve Pneumonia Treatment
11. Complicated Grief Needs Specific Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: