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Specific Imbalance Between Two Peptides may Cause Alzheimer's

the good molecule, are like Yin and Yang in Taiji. The brain can only function normally when they are in balance," he added.

The study, to be published in the Journal of Molecular Biology, shows that when there is 15 times more AB40 than AB42, the formation of AB42 fibrils is almost completely stopped.

"This means that the introduction of AB40 to tip the peptide balance toward AB40 could potentially halt or slow down the progression of the Alzheimers in the human brain," Wang said.

Wang plans to continue investigating how AB40 halts the formation of AB42 fibrils.

"This has the potential to become a simple therapy to prevent the formation of toxic AB42 species. I plan to continue my research on the role of AB40 and hope that we can test this theory on human neurons, animal models, and someday in clinical trials. One critical advantage of using AB40 for the prevention or therapy for Alzheimers is that AB40 is already known to be largely free of side effects at near physiological concentration," he said.


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