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Soy Isoflavones Linked to Lower Prostate Cancer Risk

sociated with a dose-dependent decrease in the risk of localized cancer, with relative risks for men in the highest quartile of genistein, daidzein, and soy food consumption compared with the lowest of 0.52, 0.50, and 0.52, respectively," stated the researchers.

In contrast, increased isoflavone intake was found to enhance the risk of advanced prostate cancer, said Kurahashi.

The mechanism behind the benefits was linked to the weak oestrogenic activity of soy isoflavones, which may act to reduce testosterone levels and inhibit 5á-reductase - an enzyme involved in the metabolism of testosterone.

"Given that Japanese consume isoflavones regularly throughout life, we do not yet know the period during which the effects of isoflavones on prostate cancer are preventive," concluded the researchers.

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