Navigation Links
South Asians in US More Prone to Heart Disease

Washington: South Asian immigrants in America have a higher risk of heart disease than any other segment of the American population, according to a new study led by an// Indian American doctor.

The trouble, Medical College of Georgia (MCG) researchers suspect, is that their high-density lipoprotein, or so-called good cholesterol, doesn't protect many of them like it should and their new lifestyle makes that situation worse.

"Research shows that while only 9 percent of whites develop coronary artery disease, between 18 and 25 percent of South Asian immigrants eventually develop it," says Dr. Sunita Dodani, MCG epidemiologist and cardiologist. "Interestingly, South Asians who live in their homelands have normal rates of the disease."

In most South Asians, dysfunctional HDL, first identified by the historic Framingham Heart Study, is likely caused by a mutation of Apo-A1, the gene responsible for coding the major protein component of HDL, Dr. Dodani says.

"HDL can only protect people from heart disease if it's functional," she explains. "The dysfunctional HDL and external risk factors like stress from moving and new jobs and high-fat diets make for a deadly combination."

Since joining MCG in October, Dr. Dodani, a South Asian immigrant herself, and collaborators at MCG and the University of California (UCLA) at Los Angeles have been studying 29 Augusta immigrants, looking for a connection between the gene mutation and dysfunctional HDL.

Blood samples were sent to UCLA to determine whether each subject had dysfunctional HDL. DNA sequencing helped researchers look for mutations of Apo-A1 and a portable carotid Doppler machine measured the thickness of carotid arteries, an indicator of impending coronary artery disease.

"Recent research has shown that thickening of the carotid arteries is directly related to thickening of the coronary arteries," Dr. Dodani, the new assistant dean for resear ch in the School of Nursing, says. "The Doppler machine is less invasive than angiography (which includes injecting a contrast medium into the patient) and can just as easily detect the disease in the early stages."

Dr. Dodani and her colleagues suspected that if a subject had thickening of the carotid arteries, he or she would also have dysfunctional HDL and a polymorphism of the Apo-A1 gene. This is the first time researchers have examined a possible correlation between the gene polymorphisms, dysfunctional HDL and arterial thickness.

Interestingly, 40 percent of the study population had arterial thickness and, among that group, 17 percent had high blood pressure and more than 30 percent had high cholesterol. Half the study population also had dysfunctional HDL. DNA analysis of those blood samples also found six different mutations of Apo-A1.

"This is a strong indicator that these novel polymorphisms, which haven't been found in any previous studies, are linked to dysfunctional HDL," Dr. Dodani says. "These findings support our theory that the disease, in South Asians, is most likely caused by a combination of things - a dysfunctional HDL caused by a genetic polymorphism. Add the stresses of moving, high-stress jobs and high-fat diets and that could explain the high rates in immigrants and not those who stay in their homelands."

The next step, Dr. Dodani says, is expanding the study to include more people. She has applied for National Institutes of Health funding to do that over the next two years and eventually include other populations for comparison.

"Then we will be able to figure out what's next," she says. "If the cause is a combination of this gene mutation and other factors, are there preventive strategies that we can employ? Should cholesterol-lowering drugs be started earlier in certain populations? Those are questions we hope to eventually answer."

Source-IANS
'"/>




Related medicine news :

1. South Africa dilly-dallying on AIDS situation
2. Cipla holds talks with mining giant to supply AIDS drugs for South African workers
3. South Africa Wins landmark case against pharmaceutical giants
4. Over Six Million HIV Infected People In South Africa- Finds A Survey
5. The Kidney Transplantation conspiracy in South Africa
6. Phase II trails of new HIV vaccine to be held in South Africa
7. South Africa May Start Manufacturing Bird Flu Vaccines
8. Smoking Banned In Southeast Asian Games Venues
9. AIDS bias successfully overcome by Indian Muslims in South Africa
10. Increase in the Number of Cases of Animal Diseases in New South Wales.
11. Possibility Of Bird Flu Outbreak In South Africa Ruled Out
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... ... April 24, 2017 , ... MAP Health Management announced ... in people with addiction who are served by MAP’s patient engagement ecosystem. Lief ... that monitors heart and breath rates to identify anxiety levels and can provide ...
(Date:4/24/2017)... ... April 24, 2017 , ... As a former supermodel known for her timeless ... news for single women is that she put all the words in her new ... Joan's insight, personal experiences and sparkling sense of humor have inspired her to write ...
(Date:4/24/2017)... KNOLLS, Calif. (PRWEB) , ... April 24, 2017 , ... ... health topics, but she has not found any of them to be very practical. ... actions to slowly and easily make changes in their health. It prompted her in ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... “Learning to ... to navigate life. “Learning to Use Your SPIRITUAL COMPASS To Navigate Life Issues” ... for various nonprofits, former Chairman of the Board of Directors for CONTACT USA, and ...
(Date:4/24/2017)... ... , ... Life of Purpose Treatment is proud to present “An Evening for ... 7:30 pm on May 10th at the University Auditorium. , This benefit concert, featuring ... the UF Collegiate Recovery Community (UFCRC). The concert will kick off the 5th Annual ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 Cardiology devices segment is anticipated to reach ... The Cardiology Devices segment is likely to create absolute $ ... 2018 over 2017. By the end of 2027, Cardiology Devices ... US$ 700 Mn, expanding at a CAGR of 18.4% over ... Asia Pacific reprocessed medical devices market in ...
(Date:4/19/2017)... VIEW, Calif. , April 19, 2017  IRIDEX ... it will release financial results for the first quarter ... 3, 2017.  The Company,s management team will host a ... 5:30 p.m. ET. Investors interested in listening ... (844) 707-0665 for domestic callers or (703) 326-3030 for ...
(Date:4/19/2017)... 2017 Global Prostate Cancer Therapeutics Market: ... prostate cancer therapeutics market analyzes the current and ... of prostate cancer, launch of promising emerging therapies, ... new drugs & therapeutic biological products, and high ... lesser side effects are some of the drivers ...
Breaking Medicine Technology: