Navigation Links
South Asians in US More Prone to Heart Disease

Washington: South Asian immigrants in America have a higher risk of heart disease than any other segment of the American population, according to a new study led by an// Indian American doctor.

The trouble, Medical College of Georgia (MCG) researchers suspect, is that their high-density lipoprotein, or so-called good cholesterol, doesn't protect many of them like it should and their new lifestyle makes that situation worse.

"Research shows that while only 9 percent of whites develop coronary artery disease, between 18 and 25 percent of South Asian immigrants eventually develop it," says Dr. Sunita Dodani, MCG epidemiologist and cardiologist. "Interestingly, South Asians who live in their homelands have normal rates of the disease."

In most South Asians, dysfunctional HDL, first identified by the historic Framingham Heart Study, is likely caused by a mutation of Apo-A1, the gene responsible for coding the major protein component of HDL, Dr. Dodani says.

"HDL can only protect people from heart disease if it's functional," she explains. "The dysfunctional HDL and external risk factors like stress from moving and new jobs and high-fat diets make for a deadly combination."

Since joining MCG in October, Dr. Dodani, a South Asian immigrant herself, and collaborators at MCG and the University of California (UCLA) at Los Angeles have been studying 29 Augusta immigrants, looking for a connection between the gene mutation and dysfunctional HDL.

Blood samples were sent to UCLA to determine whether each subject had dysfunctional HDL. DNA sequencing helped researchers look for mutations of Apo-A1 and a portable carotid Doppler machine measured the thickness of carotid arteries, an indicator of impending coronary artery disease.

"Recent research has shown that thickening of the carotid arteries is directly related to thickening of the coronary arteries," Dr. Dodani, the new assistant dean for resear ch in the School of Nursing, says. "The Doppler machine is less invasive than angiography (which includes injecting a contrast medium into the patient) and can just as easily detect the disease in the early stages."

Dr. Dodani and her colleagues suspected that if a subject had thickening of the carotid arteries, he or she would also have dysfunctional HDL and a polymorphism of the Apo-A1 gene. This is the first time researchers have examined a possible correlation between the gene polymorphisms, dysfunctional HDL and arterial thickness.

Interestingly, 40 percent of the study population had arterial thickness and, among that group, 17 percent had high blood pressure and more than 30 percent had high cholesterol. Half the study population also had dysfunctional HDL. DNA analysis of those blood samples also found six different mutations of Apo-A1.

"This is a strong indicator that these novel polymorphisms, which haven't been found in any previous studies, are linked to dysfunctional HDL," Dr. Dodani says. "These findings support our theory that the disease, in South Asians, is most likely caused by a combination of things - a dysfunctional HDL caused by a genetic polymorphism. Add the stresses of moving, high-stress jobs and high-fat diets and that could explain the high rates in immigrants and not those who stay in their homelands."

The next step, Dr. Dodani says, is expanding the study to include more people. She has applied for National Institutes of Health funding to do that over the next two years and eventually include other populations for comparison.

"Then we will be able to figure out what's next," she says. "If the cause is a combination of this gene mutation and other factors, are there preventive strategies that we can employ? Should cholesterol-lowering drugs be started earlier in certain populations? Those are questions we hope to eventually answer."

Source-IANS
'"/>




Related medicine news :

1. South Africa dilly-dallying on AIDS situation
2. Cipla holds talks with mining giant to supply AIDS drugs for South African workers
3. South Africa Wins landmark case against pharmaceutical giants
4. Over Six Million HIV Infected People In South Africa- Finds A Survey
5. The Kidney Transplantation conspiracy in South Africa
6. Phase II trails of new HIV vaccine to be held in South Africa
7. South Africa May Start Manufacturing Bird Flu Vaccines
8. Smoking Banned In Southeast Asian Games Venues
9. AIDS bias successfully overcome by Indian Muslims in South Africa
10. Increase in the Number of Cases of Animal Diseases in New South Wales.
11. Possibility Of Bird Flu Outbreak In South Africa Ruled Out
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
(Date:9/22/2017)... 22, 2017  As the latest Obamacare repeal effort ... Cassidy (R-LA) and Lindsey Graham (R-SC) ... medical device industry is in an odd place.  The ... 2.3% excise tax on medical device sales passed along ... covered patients, increased visits and hospital customers with the ...
Breaking Medicine Technology: