Navigation Links
Smoking Hampers Healing of the Ligament

Researchers at the Washington University School of Medicine in St. Louis have just given people another reason to kick the butt by revealing that smoking interferes with ligament healing.

The researchers conducted a study on a mouse model and found that cigarette smoking impairs the recruitment of cells to the injury site and delays healing following ligament repair surgery.

The researchers looked at the mouse medial collateral ligament (MCL), a ligament that supports the knee joint in both mice and people.

MCL injuries are the most common, and are also the most common injuries seen in competitive and recreational sports.

Previous studies have demonstrated that the mouse provides a good paradigm for what happens in injured human knees.

"This is a good model for knee ligament injury, but it could be a model for ligament injuries anywhere in the body. It's likely the biology is transferable to other knee ligaments, elbow ligaments, shoulder ligaments, you name it," says co-investigator Linda J. Sandell, Ph.D., professor of orthopaedic surgery.

To look at the effects of smoking, Sandell, Wright and their colleagues used a system developed at the School of Medicine in which mice are placed inside smoking chambers six days per week.

The mice were exposed to enough passive fumes to make up for two cigarettes daily, the equivalent of a person smoking about four packs per day.

They were placed in the smoking chambers for two months prior to MCL surgery and then again after surgery to mimic the behaviour of humans who continue to smoke following an injury.

Soft tissue healing that occurs following ligament injuries occurs in stages. There is an immediate pooling of blood near the injury, the sort of hemorrhaging that will cause swelling right away. This initial response is followed by several days of inflammation, in which cells called macrophages fl ock to the injury site and secrete substances called cytokines and chemokines. Those, in turn, recruit more cells to assist in healing. That process of cellular proliferation and synthesis lasts for several days to several weeks. The final stage of healing involves remodeling of the tissue and can continue for months and even years.

An earlier study found an increase in cell density and in gene activity to produce type I collagen in the first week following MCL injury, so in this study the researchers paid close attention to cell density, biomechanical function and gene expression during the first week after MCL repair. In mice exposed to cigarette smoke, cell density was lower and type I collagen gene expression was reduced.

"Our studies also have shown a decreased macrophage response that may help explain why we see this delayed or decreased healing response," Wright says.

Sandell and Wright say their findings point to yet another reason smokers would do well to quit.

"Many patients don't want to hear it, but these results suggest that smoking affects anyone who needs ligament-repair surgery. I counsel surgery patients to at least try to decrease smoking because, if nothing else, that will improve the healing of their surgical incisions. Quitting smoking is good health management regardless, but in patients having this kind of surgery, there are extra advantages." Wright says.

The findings of the study are reported in the Journal of Orthopaedic Research.


'"/>




Related medicine news :

1. New hope on the Horizon for People Wishing to Quit Smoking
2. Cancers of Colon & Rectum linked to Cigarette Smoking
3. Smoking a greater risk than HIV? Yes say health experts!!!!
4. Kick Smoking with Nicotine Drink
5. Smoking spreads Cancer
6. Prescription Drug - Helps People Stop Smoking
7. Quit Smoking
8. Smoking can depreciate intellegence
9. Smoking Delays Pregnancy
10. Smoking Linked To Low Infant Birth Weight
11. GlaxoSmithKline To Cultivate Non-Smoking Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2017)... (PRWEB) , ... April 26, ... ... which provides an agile ecosystem and domain expertise for sponsors and CROs ... randomization and trial supply management (RTSM) software platform. Bioclinica AGILE RTSM ...
(Date:4/25/2017)... ... 25, 2017 , ... Bellus Medical, a leader in medical ... new class of photodynamic cosmetics (PDC). , Allumera® is the first PDC cream ... of aging, and minimize the appearance of pores – all with minimal downtime ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... they have signed an agreement to be the preferred physical therapy provider for ... and returning them to Derby City CrossFit as quickly and effectively as possible, ...
(Date:4/25/2017)... ... April 25, 2017 , ... A stressful work environment ... can also decrease overall productivity and performance in the workplace. The goal of Clearview ... the last few weeks of April, Clearview Resolution Services will be shutting down the ...
(Date:4/25/2017)... ... April 25, 2017 , ... A recent report from the ... for the 2015-16 school year across Wisconsin’s public schools, charter schools, and private ... patterns in student test score performance, the report’s limited analyses fail to provide ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017  New research provides evidence that an old drug ... a study released today that will be presented at the ... Boston , April 22 to 28, 2017. ... Parkinson,s disease, the oral drug levodopa has long been considered ... as the disease progresses, the effects of the medication can ...
(Date:4/19/2017)... THOUSAND OAKS, Calif. , April 19, 2017 ... premium industrial buildings it is developing at Conejo ... California , to Atara Biotherapeutics, Inc. ... patients with severe and life-threatening diseases that have ... focus on allogeneic T-cell therapies for cancer, autoimmune ...
(Date:4/18/2017)... MINNEAPOLIS , April 18, 2017 Cogentix ... focused on providing the Urology, Uro/Gyn and Gynecology markets ... for the first quarter ended March 31, 2017 after ... The Company will host a conference call ... day on Tuesday, May 2, 2017 at 4:30 p.m. ...
Breaking Medicine Technology: