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Slowing the Racing Heart

and potassium channels that we know to be key players in the generation and regulation of the pacemaker activity," said Ke.

"Although adrenaline and other mechanisms that accelerate the heart rate have been well studied, mechanisms that might act as a brake are poorly understood," said Solaro.

"Identification of this previously unknown molecular mechanism for slowing the heartbeat may offer new avenues of diagnosis, drug design and treatment of many common heart diseases," said Solaro.

"Further, now that we know something of how this enzyme works in the pacemaker cell, we may discover it is involved in the regulation of other processes, particularly in the brain, where it is also highly expressed," added Ke.


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