Navigation Links
Skin cancer linked to usage of Drug Azathioprine in organ transplants

The Drug Azathioprine, which is used as an immunomodulating drug in patients with organ transplants,// arthritis, inflammatory bowel disease and autoimmune disorders is found to increase the incidence of skin cancer in these patients.

Professor Peter O’Donovan and colleagues from London Research Institute in Hertfordshire has found that Azathioprine accumulates in the DNA of the patient taking the drug and when the skin is exposed to sunlight, the Ultraviolet rays of the sun triggers mutations in the DNA causing skin cancers. It was found that the drug Azathioprine which is accumulated in the DNA interacts with UV-light forms an irreversible photoproduct. Azathioprine is used for treatment of auto immune disorders such as Lupus erythematous which involves multiple organs such as lungs, kidneys and joints, the dosage of the drug taken by these patients is equal to the risk of development skin cancer as mentioned in this study. The risk is avoided in these patients as these patients are already advised to keep away from sunlight.

When examination of the patients taking the Azathioprine was done, it was found that these patients were more and abnormally sensitive to UV rays, even to a dose of one to two minutes of sunlight exposure. Moreover, skin cancer is 50 to 250 times more common among transplant patients than general population. Due to accumulation of drug in the DNA interaction of the UV light with the skin increases the risk of skin cancer. The possibility of skin cancer occurrence also depends upon the dosage of the drug and duration of the drug taken. The risk of skin cancer in organ transplants is more due to long duration and increased dosage of the drug taken.

(Source: BBC News)

For Information on Skin Biopsy in Medindia:

Skin biopsy is taken when there is an infection or disease in the skin, which requires further examination. A small piece of tissue is cut with the help of the blad e/ knife under sterile conditions, after cleaning the surface of the skin. '"/>




Related medicine news :


1. Vitamin B12 can help in detecting cancers
2. Want skin cancer? Please have a cigarette
3. New hope for cancer victims – will vaccine cure the deadly bug
4. Clintons new problem - Is the outgoing American president suffering from skin cancer?
5. Are cancer patients being taken for a ride?
6. Breast cancer treatment to be determined by gene test
7. Ductal lavage may detect early breast cancer
8. Beware of the oral patch! It could be cancer!!!
9. New drug helps boost cancer treatment
10. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
11. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... ... Word: Chocolate Biscuit”: a biographical account following a man who went on to support his ... Marlyn Ivey, born in Lynn Haven, Florida and at the age of 5, his family ... age, he joined the Navy and got married right out of boot camp. , ...
(Date:1/20/2017)... ... 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and colorful ... Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, and ... “I have been writing since high school and have many different titles,” Gaapf mentions ...
(Date:1/19/2017)... ... ... Next week after January 20th, the fear for many is that the ... needs of over 30 million. Many interviews with Dr. Carol Francis at the Los ... were suppose to prioritize. Interviews provided below. , Among those present was ...
(Date:1/19/2017)... ... , ... WhoHaha , a digital media company dedicated to creating and ... produce a three-part video series that uses humor to highlight ways to improve heart ... AHA’s Healthy For Good™ movement, which is designed to inspire all Americans to make ...
(Date:1/19/2017)... Plains, NJ (PRWEB) , ... January 19, 2017 ... ... board certified dermatologist by the American Board of Dermatology and fellowship trained Mohs ... of the National Institutes of Health, Dr. Li completed his internship in internal ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Report Details What can be expected ... to grow at the fastest rates? This visiongain report ... opportunities and prospects. Our 190-page report provides 124 ... in the industry and the future market prospects. Our ... all the major categories of the ophthalmic devices market. ...
(Date:1/19/2017)... 19, 2017 This report on the opioid ... scenario of the global market. Large number of chronic ... chronic constipation is a major side effect of consumption ... novel targeted therapy has been prescribed to treat opioid ... targeted medicines, and growing awareness about the therapy are ...
(Date:1/19/2017)... , Jan. 19, 2017 Accuray Incorporated (Nasdaq: ... and TomoTherapy® Systems continue to set the bar for ... highest composite overall user satisfaction rating among radiation treatment ... 2016 MD Buyline Market Intelligence Briefing™. The most recent ... composite ratings among industry peers for 11 of the ...
Breaking Medicine Technology: