Navigation Links
Skin cancer linked to usage of Drug Azathioprine in organ transplants

The Drug Azathioprine, which is used as an immunomodulating drug in patients with organ transplants,// arthritis, inflammatory bowel disease and autoimmune disorders is found to increase the incidence of skin cancer in these patients.

Professor Peter O’Donovan and colleagues from London Research Institute in Hertfordshire has found that Azathioprine accumulates in the DNA of the patient taking the drug and when the skin is exposed to sunlight, the Ultraviolet rays of the sun triggers mutations in the DNA causing skin cancers. It was found that the drug Azathioprine which is accumulated in the DNA interacts with UV-light forms an irreversible photoproduct. Azathioprine is used for treatment of auto immune disorders such as Lupus erythematous which involves multiple organs such as lungs, kidneys and joints, the dosage of the drug taken by these patients is equal to the risk of development skin cancer as mentioned in this study. The risk is avoided in these patients as these patients are already advised to keep away from sunlight.

When examination of the patients taking the Azathioprine was done, it was found that these patients were more and abnormally sensitive to UV rays, even to a dose of one to two minutes of sunlight exposure. Moreover, skin cancer is 50 to 250 times more common among transplant patients than general population. Due to accumulation of drug in the DNA interaction of the UV light with the skin increases the risk of skin cancer. The possibility of skin cancer occurrence also depends upon the dosage of the drug and duration of the drug taken. The risk of skin cancer in organ transplants is more due to long duration and increased dosage of the drug taken.

(Source: BBC News)

For Information on Skin Biopsy in Medindia:

Skin biopsy is taken when there is an infection or disease in the skin, which requires further examination. A small piece of tissue is cut with the help of the blad e/ knife under sterile conditions, after cleaning the surface of the skin. '"/>




Related medicine news :


1. Vitamin B12 can help in detecting cancers
2. Want skin cancer? Please have a cigarette
3. New hope for cancer victims – will vaccine cure the deadly bug
4. Clintons new problem - Is the outgoing American president suffering from skin cancer?
5. Are cancer patients being taken for a ride?
6. Breast cancer treatment to be determined by gene test
7. Ductal lavage may detect early breast cancer
8. Beware of the oral patch! It could be cancer!!!
9. New drug helps boost cancer treatment
10. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
11. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... products to meet the demand of today’s consumer and regulatory authorities worldwide. From ... probiotic experts and tested to meet the highest standard. , These products ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: