Navigation Links
Skin Cancer can Be Triggered by P53 Mutation

Two separate studies by research teams at Glasgow University and Baylor College of Medicine uncover 2 previously unidentified regulators of SCC development, providing insights into the development of this potentially lethal disease.

Squamous cell carcinoma (SCC) is a form of nonmelanoma skin cancer, which is the most common type of human malignancy with over 1 million new cases in the USA each year.

Mutations in the p53 tumor suppressor gene have been implicated in tumor formation: some give rise to a loss-of-function whereas the majority of mutations result in a gain-of-function.

In the first of these two studies, Dennis Roop, Carlos Caulin, and colleagues from Baylor College of Medicine, set out to determine whether gain-of-function or loss-of-function mutations in p53 are more critical for SCC development.

The authors show that certain p53 mutations occurring in human SCCs demonstrate gain-of-function properties that accelerate the frequency and progression of malignant SCC. Future studies will hopefully discover ways to target these mutations for therapeutic purposes.

A link between skin inflammation and SCC formation was first reported in the 19th century. In the second of these 2 new JCI studies, Robert Nibbs, Gerard Graham, and colleagues from Glasgow University show that the chemokine receptor D6 acts to sequester inflammatory molecules known as chemokines and as such is essential to suppressing the development of skin cancer.

They show that D6-deficient mice are acutely sensitive to SCC formation and that D6 expression is induced in cells in close proximity to invasive SCC cells from human oral SCCs. In the absence of D6, skin inflammation sensitizes skin cells to tumor formation.

In an accompanying commentary on these two studies, David Owens from Columbia University in New York comments that if a heightened inflammatory state in the skin can influence p53 gain- of-function status, this may have important implications for the prognosis of SCCs. AUTHOR CONTACT: Dennis R. Roop University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA. E-mail: dennis.roop@uchsc.edu


'"/>




Related medicine news :

1. Fibroids unlikely to Turn Cancerous
2. Virus Level could Predict Cervical Cancer Risk
3. Cancer Doctors Okays Controversial Prostate Therapy
4. Potential New Cancer Gene Identified
5. Consensus on "Combination Therapy" for Breast Cancer
6. Cancers of Colon & Rectum linked to Cigarette Smoking
7. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
8. The Cancer Rumour mill working over time
9. Cancer drugs in development nearly doubled since 1995
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. Cancer patients turning to Internet for information
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... ... April 28, 2017 , ... Intellitec Solutions announced ... Foundation implement a Microsoft Dynamics GP solution that integrates to their PointClickCare EHR ... specializes in long-term care, Brooke Grove now has the capability to achieve its ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular SearchLight Spectra ... modeling resource for fluorescence microscopists and optical system designers, enabling The Right Solution, ... spanning the globe, SearchLight has become a tremendously popular tool for the fluorescence ...
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... Healthcare companies ... But they will rapidly reject an outdated healthcare executive resume. , “If you’re a ... at your executive resume and wondering if it’s as ready as you are for ...
(Date:4/27/2017)... Reston, VA (PRWEB) , ... April 27, 2017 ... ... mobile application containerization, today announced an exhibitor sponsorship at MobileIron Live! 2017 ... leaders, and new technologies for an immersive, educational approach to helping organizations maximize ...
(Date:4/27/2017)... ... April 27, 2017 , ... Plastic Surgery Associates is excited to announce ... present at the upcoming Aesthetic Meeting. Held in San Diego, at the San Diego ... Canales will lend their expertise to the Premier Global Hot Topics session, speaking on ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  CVS Pharmacy, the retail division ... new store design to enhance the retail customer ... health-focused products and expanded beauty selections paired with ... discover new offerings. Together with its innovative digital ... the customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... Eyevensys, a private biotechnology company ... expression technology that enables the safe, local, sustained production ... wide range of ophthalmic diseases, announces it has received ... Agency (MHRA) to advance its technology into clinical development. ... The EyeCET ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment is ... period The Cardiology Devices segment is likely to ... 15 Mn in 2018 over 2017. By the end of ... valuation close to US$ 700 Mn, expanding at a CAGR ... dominated the Asia Pacific reprocessed medical ...
Breaking Medicine Technology: