Navigation Links
Sitagliptin, Under Investigation For Type 2 Diabetes

The number of people suffering from diabetes is already over 194 million worldwide and the number is expected to increase by 333 million by 2025. Type II diabetes is also known as non-insulin dependent diabetes // and is characterized by a relative disparity between endogenous insulin production and insulin requirements, leading to an elevated glucose. In contrast to Type I diabetes, there is always some endogenous insulin production, and many patients have normal or even elevated blood insulin levels. The disease usually occurs over the age of 40 and treatment involves diet, oral hypoglycemic drugs and exogenous insulin.

However, side effect profile of the given medication, route of administration or difficulties in sustaining glucose control pose serious concerns and necessitate more tolerable treatments that do not cause weight gain and produce less risk of hypoglycemia for patients with type 2 diabetes.

Clinical phase II studies involving Sitagliptin, an investigational diabetes drug, appears to control blood sugar with a low incidence of hypoglycaemia and with a neutral effect on body weight.

Sitagliptin is expected to lower blood glucose levels by increasing the level of active incretin hormones which increase insulin from pancreatic beta-cells and decrease glucagon from pancreatic alpha cells in a glucose-dependent manner (when blood glucose is elevated and not when blood glucose is low). If approved, Sitagliptin would be a member of a new class of antihyperglycaemic agents called DPP-IV inhibitors, which inhibit the DPP-4 enzyme that normally inactivates the incretin gut hormones GLP-1 and GIP. The patients studied exhibited a safety and tolerability profile similar to placebo. In addition, patients taking Sitagliptin experienced no significant weight gain and a low risk of hypoglycaemia. Patients treated with glipizide had an average weight gain of 1.1 kilogram relative to placebo. Adverse event reports of hypoglycaemia were observed in 4 percent of patients taking Sitagliptin, 17 percent of patients taking glipizide and 2 percent of patients taking placebo.

Results from the studies conducted to date are very promising and ongoing Phase III trials are expected to provide greater insight into the efficacy and tolerability profile of Sitagliptin over a longer period of time.


'"/>




Related medicine news :

1. Undertaking the obesity epidemic
2. Breast Cancer in Men Often Underestimated and Under-treated
3. Drug to Lower Cholesterol Underused
4. Understanding The Predictors Of Prostate Cancer
5. Understanding Restless Legs Syndrome
6. Understanding Lung Cancer Metastasis
7. Understanding The Link Between Hormone Replacement and Respiratory Disease
8. Understanding The Risks Of Hormone Therapy
9. Understanding The Link Between Metabolic Syndrome And Drinking Patterns
10. A Better Understanding Of The Brain Network
11. Understanding The Predictor’s Of Alzheimer’s Diseae
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
Breaking Medicine Technology: