Navigation Links
Single Sugar Enables Antibody to Treat Inflammation

For years, researchers have struggled to understand how IVIG worked. Its ability to treat autoimmune diseases seemed to be an apparent contradiction.//

Intravenous immunoglobulin (IVIG) is a complex mixture of IgG antibodies made from human plasma that contains the pooled antibodies from thousands of people, and is only FDA-approved to treat a few assorted conditions; nonetheless, practitioners have used it off-label with varied success in patients with lupus, arthritis and asthma, among other autoimmune disorders. In the body, the antibodies in plasma act as part of the immune response to identify and deactivate foreign invaders. When they begin attacking the body's own cells, the same protective immunoglobulins (known as IgG antibodies) can cause autoimmune disorders like lupus, arthritis and asthma. And yet, when IVIG is infused into people with those exact autoimmune conditions, it calms inflammation rather than causes it.

Jeffery Ravetch, Theresa and Eugene M. Lang Professor and head of Rockefeller's Leonard Wagner Laboratory of Molecular Genetics and Immunology, was struck by this inconsistency. "If IgG triggers autoimmune disease, how could it be pathogenic and therapeutic?" he asked. "We call it the IgG paradox." Six years ago he started an investigation into exactly how IVIG worked, and what he's discovered could one day lead to a whole new class of therapeutics. In a paper published in the August 4 issue of the journal Science, Ravetch and his colleagues, Falk Nimmerjahn and Yoshi Kaneko, explain what makes IVIG effective: A small fraction of the IgG antibodies in the IVIG solution carry a sugar called sialic acid that is required for its protective ability.

IgG antibodies bind to and activate specific immune cells, with different forms or "subclasses" binding to specific receptors (called Fc receptors) on the immune cell's surface. Antibody subclasses have different abilities to induce inflammation in the body by virt
'"/>




Page: 1 2 3

Related medicine news :

1. Single gene analysis for diagnosis of a range of blood disorders
2. Single drug for bipolar disorder
3. Treating Testicular Cancer With A Single Dose Of Chemotherapy
4. Decreasing Multiple Births By Single Embryo Transfers
5. Single gene skin cancer cause
6. Drug Firms To Produce Single Pill AIDS Treatment
7. Malaria May Gain Resistance To Single Drug Prescriptions
8. Single Women with Baby Cravings Can Actually Cradle their Own, Courtesy NHS
9. Thai Doctors Removed 421 Kidney Stones From A Single Person
10. Single Dose Of Azithromycin Could Cure Trichiasis
11. Effects Of Certain Food Related To Single Pain Receptors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Single Sugar Enables Antibody Treat Inflammation

(Date:6/1/2015)... June 02, 2015 The National ... Willey as a 2015-2016 inductee into its VIP ... with this prestigious distinction for leadership in safety, environment, ... networking organization exclusively for professional women, boasting more than ... "I’m pleased to present Lourinda with this important honor,” ...
(Date:6/1/2015)... 02, 2015 Dr. Robert ... Piedmont Physical Medicine & Rehabilitation, P.A., has published ... of stem cell therapy for knees, and highlights ... preferred alternative to arthroscopy or knee joint replacement. ... of Neuromusculoskeletal, Vascular and Regenerative Medicine, writes that ...
(Date:6/1/2015)... 01, 2015 Atagi Plastic Surgery and ... named an Ultherapy® Ultra Treatment Provider by ... Skin Aesthetics is one of only six practices in ... treatment provider. , Atagi Plastic Surgery and Skin ... area has led the practice to earn the distinction ...
(Date:6/1/2015)... 2015 The Muscular Dystrophy Association ... in participating in the sold out 2015 Bank ... secure guaranteed entry by signing up through the ... space is limited. , This national endurance program ... and abilities, and a supportive community of teammates, ...
(Date:6/1/2015)... (PRWEB) June 01, 2015 Note: Dr. ... development in breast cancer prevention. , A phase III ... that postmenopausal women with ductal carcinoma in situ (DCIS) ... and prevention. , The study (NSABP B-35/NRG Oncology) looked ... completed the standard five-year treatment with tamoxifen to those ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Lourinda Willey, Owner and Principal of Lourinda R. Willey LLC, Into its VIP Professional Woman of the Year Circle 2Health News:New Article by Dr. Robert G. Schwartz of Piedmont Physical Medicine & Rehabilitation Looks at Benefits of Stem Cell Therapy for Knees 2Health News:New Article by Dr. Robert G. Schwartz of Piedmont Physical Medicine & Rehabilitation Looks at Benefits of Stem Cell Therapy for Knees 3Health News:Atagi Plastic Surgery and Skin Aesthetics Named Ultherapy® Ultra Treatment Provider 2Health News:Sold Out 2015 Bank of America Chicago Marathon and Marine Corps Marathon Entries Still Available through MDA Team Momentum 2Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 2Health News:Today at ASCO: Anastrazole Offers Higher Breast Cancer-Free Survival Rates than Tamoxifen Following DCIS, Phase III Study Shows 3
... complication that can occur in children affected by acute ... attack, pulmonary embolism and other cardiovascular diseases//. ... Italy by the Laboratory of Genetic and Environmental Epidemiology ... collaboration with the Haematology Division of the University of ...
... Prexige is said to be linked to an increased risk ... warned to exercise caution in its use.// ,The ... Prexige (generic name, lumiracoxib) available from Tuesday. The drug is ... it was found in 2004 that these group of drugs ...
... have suggested that cross-immunity created in response to infection ... //,by related serotypes thus leading to the waxing and ... help understand the pattern of this deadly mosquito-borne illness ... 1980s, there's been a sequential replacement of the dominant ...
... Indiana University School of Medicine it was found that ... the life span of those suffering from compromised immune ... the journal of Biological Chemistry. These proteins can be ... boost the patient’s immune system. The lead researcher Roman ...
... been criticized severely because a staff nurse has refused to send ... Mary Smith, 87 had an agonizing pain in her lower abdomen. ... replied that she could not have an ambulance and had to ... her. Then when the GP arrived he just gave her some ...
... minds of many cancer survivors. After treatment, as life ... makers now //,consider a chronic condition, survivors need to ... choices to ensure quality-of-life. This national movement, commonly referred ... year. ,Steps for Living (SFL), a nonprofit ...
Cached Medicine News:Health News:Thrombosis, a Serious Risk in Children with Leukemia 2Health News:New Arthritis Drug Linked to Increased Risk of Heart Attacks 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 3Health News:New Music Project Promotes Quality-of-Life After Cancer 2
(Date:6/1/2015)... , June 1, 2015  Diomics, an innovator in ... Weissman , global financial executive, has joined Diomics, board ... more than 25 years of industry experience in broad ... as a managing director at Credit Suisse and JP ... Stanley/Dean Witter. "Diomics is on the forefront ...
(Date:6/1/2015)... Research and Markets  ( http://www.researchandmarkets.com/research/4lw2mn/global_a_dialyzer ) ... A Dialyzer Reprocessing Machine (A Dialyzer Reprocessor ) ... The Global A Dialyzer Reprocessing Machine ... a professional and in-depth study on the current ... The report provides a basic overview of ...
(Date:6/1/2015)... BROOK, N.J. , June 1, 2015 /PRNewswire/ ... Food and Drug Administration (FDA) has accepted for ... for Anthim® (obiltoxaximab) for the treatment and prevention ... was submitted on March 20, 2015. Anthim is ... National Stockpile, the U.S. government,s repository of critical ...
Breaking Medicine Technology:Richard M. Weissman joins Diomics Board of Directors 2Global A Dialyzer Reprocessing Machine (A Dialyzer Reprocessor) Industry Report 2014 - Development Trends Forecasts to 2020 2Global A Dialyzer Reprocessing Machine (A Dialyzer Reprocessor) Industry Report 2014 - Development Trends Forecasts to 2020 3U.S. Food And Drug Administration Accepts Biologics License Application For Anthim (Obiltoxaximab) 2U.S. Food And Drug Administration Accepts Biologics License Application For Anthim (Obiltoxaximab) 3
... March 19 FluoroPharma Inc., a company,developing breakthrough ... (PET) market, announced commencement of Phase,I clinical trials ... the proposed studies. The Phase I trial is ... safety, distribution and dosimetry,of BFPET as a PET ...
... KNOLLS, N.J., March 19 Emisphere,Technologies, Inc. (Nasdaq: ... studies demonstrating that its proprietary eligen(R) technology,enhances the ... than were,used previously. The lower doses are believed ... the rate of absorption of B12 administered,with eligen(R) ...
Cached Medicine Technology:FluoroPharma Announces Commencement of Phase I Clinical Trial for BFPET(TM), Myocardial Perfusion Imaging (MPI) Tracer for Positron Emission Tomography (PET) 2Emisphere Announces Second Study Demonstrating Dramatic Increases in Absorption of Oral B12 Using eligen(R) Technology at Lower Doses 2Emisphere Announces Second Study Demonstrating Dramatic Increases in Absorption of Oral B12 Using eligen(R) Technology at Lower Doses 3
... Easyfield is lightweight enough to shuttle ... carrying case. Designed with a goldmann standard ... fixed-point grid with 79 locations (including 30-2, ... and 3 different suprathresholds out to 30. ...
The Oculus easyfield is an exciting new compact perimeter to do automatic static perimetry up to 30 degrees eccentricity. It has been designed for the combined use as a visual field screener and peri...
... additional hardware and software features to meet ... clinics or teaching institutions. Standard with B/Y ... for experimental or clinical studies. Ethernet connection ... further tests including Flicker- and Color perimetry, ...
... Designed around the patented ... Octopus 301 sets the trend ... decade. Ideal for routine screening ... performance, accuracy and quality ...
Medicine Products: