Navigation Links
Single Protein Plays A Major Role In Prion Diseases

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins,// creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions - strange, self-replicating proteins that cause fatal brain diseases - convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process - fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "crusher," Serio thought. '"/>




Page: 1 2

Related medicine news :

1. Single gene analysis for diagnosis of a range of blood disorders
2. Single drug for bipolar disorder
3. Treating Testicular Cancer With A Single Dose Of Chemotherapy
4. Decreasing Multiple Births By Single Embryo Transfers
5. Single gene skin cancer cause
6. Drug Firms To Produce Single Pill AIDS Treatment
7. Malaria May Gain Resistance To Single Drug Prescriptions
8. Single Women with Baby Cravings Can Actually Cradle their Own, Courtesy NHS
9. Thai Doctors Removed 421 Kidney Stones From A Single Person
10. Single Dose Of Azithromycin Could Cure Trichiasis
11. Effects Of Certain Food Related To Single Pain Receptors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Single Protein Plays Major Role Prion Diseases

(Date:3/3/2015)... 2015 NOVAtime Technology, Inc. ( ... and Attendance / Workforce Management solutions, announced that ... SaaS Workforce Management / Time and Attendance ... , Since 2004, Innovative Services’ mission has ... the best quality of life. The company is ...
(Date:3/3/2015)... New York, New York (PRWEB) March 03, 2015 ... that question tactics used to market the atypical ... around the U.S. According to court documents, the ... jury’s 2011 finding that Johnson & Johnson’s Janssen ... concealed its serious risks. However, while the Court’s ...
(Date:3/3/2015)... On February 21st, the rooftop of the ... a day-long event that features a gathering of providers ... Organized by Debbie Durkin and Durkin Entertainment, Los Angeles’ ... EcoLuxe Lounge saw many notable attendees. Among them was ... The Flash, Star Trek: Deep Space Nine and many, ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Loma Linda ... whole health and well being, it will be offering ... across its campuses. , Over the past year, a ... part in creating dietary criteria, listening to vendors, sampling ... the entire organization. , Most recently, a food ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Longtime parent ... with CARE Surrogacy Center for a candid ... originally appearing online is an exhilarating revelation of his ... have led him from Australia to the birth of ... press interchange, Tolga Umar, CEO and Founder of CARE ...
Breaking Medicine News(10 mins):Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 2Health News:Innovative Services, Inc. Successfully Migrates to Cloud-Based NOVAtime Workforce Management Solution to Support Growth and Improve Payroll Processing Time 3Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Comments on Ruling Upholding South Carolina Jury Decision in Risperdal Marketing Case 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Comments on Ruling Upholding South Carolina Jury Decision in Risperdal Marketing Case 3Health News:Hollywood Star Chase Masterson and Choices Recovery Discuss Substance Abuse and Treatment at 2015 Oscars 2Health News:Loma Linda University Health Rejuvenates Its Vending Machines with Healthier Selections 2Health News:CARE Surrogacy Center Mexico Conducts Candid Interview with Australian Father of Twins 2Health News:CARE Surrogacy Center Mexico Conducts Candid Interview with Australian Father of Twins 3
... Cell-Based ... Melanoma Therapy, BOTHELL, Wash., ... developer and marketer of,proprietary hypothermic storage and cryopreservation media products for,cells, ... products in the cellular therapy and cord blood banking,market segments., ...
... Michelle Reesman, RN, Executive,Director, Passport Health Colorado, says far ... adventurous types, leave,home without taking the basic steps she ... preparation into their health as they do into their,destination ... 1) Get advice from a travel health ...
... LENEXA, Kan., Mar. 26 Mediware Information,Systems (Nasdaq: ... systems for,blood and medication management, has announced its ... hospital,blood banks and LifeTrak(R) software for blood centers, ... standards being required in the,United States., With ...
... for Voters on Health Care and,Social Security, ... said the most recent Medicare trustees, report calls ... issues.,According to the program,s trustees, Medicare,s Hospital Insurance ... Medicare must,rely also on interest accrued on trust ...
... 26 Spheris, a leading global,outsource provider of clinical ... and twelve months ended December 31, 2007., Financial ... fourth quarter of 2007 were $48.6 million compared,with $51.4 ... million decrease,in net revenues during the fourth quarter of ...
... a company,developing breakthrough molecular imaging agents for ... it has entered into a licensing,agreement with ... and,commercialization of agents for diagnosis and treatment ... were co-developed by,FluoroPharma and MGH scientists, target ...
Cached Medicine News:Health News:BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments 2Health News:BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments 3Health News:The Top Ten Health Tips for International Travel 2Health News:ISBT 128 Labeling Implementation Date Looms for Blood Centers 2Health News:ISBT 128 Labeling Implementation Date Looms for Blood Centers 3Health News:Medicare Trustees' Report Highlights Need for Reform 2Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 2Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 3Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 4Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 5Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 6Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 7Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 8Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 9Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 10Health News:Spheris Reports Fourth Quarter and Year-End 2007 Results 11Health News:FluoroPharma Inc. Expands Technology Platform to Include Agents for Alzheimer's Disease (AD) 2
(Date:3/3/2015)... Actavis plc (NYSE: ACT ) today announced ... aggregate principal amount of senior unsecured notes in 10 ... by its indirect wholly-owned subsidiary, Actavis Funding SCS, and ... as follows: Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO ... , Due 2016 , 100.00% 1.850% Senior ...
(Date:3/3/2015)...  Vermillion, Inc. (NASDAQ: VRML ), a bio-analytical ... present at the 27 th Annual ROTH Conference, which ... Point, California from March 8 to March 11. ... Palmieri , will be presenting on Monday, March 9 at ... Schoen , the company,s Vice President of Finance and Chief ...
(Date:3/3/2015)... Fla. , March 3, 2015 ... pleased to announce the hiring of Brian ... to lead business development efforts and build relationships ... of experience in software development, sales, and sales ... enterprise software applications. iTraycer is a comprehensive inventory ...
Breaking Medicine Technology:Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 2Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 3Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 4Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 5Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 6Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 7Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 8Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 9Actavis Announces Pricing of Public Offering of Senior Notes in Connection with Pending Acquisition of Allergan 10Vermillion To Present at 27th Annual ROTH Conference on March 9 2Medical Tracking Solutions, Inc. Hires New SVP, Sales 2
... LAWRENCE, Mass., Jan. 4, 2011 NxStage Medical, Inc. ... innovative dialysis products, today announced that Jeffrey H. Burbank, ... Officer, will present at the 29th Annual J.P. Morgan ... a.m. (PST). The live webcast of NxStage,s ...
... Pharmaceuticals, Inc. (Nasdaq: OPTR ) today announced ... granted orphan drug designation from the U.S. Food and ... Clostridium difficile infection (CDI).  This orphan drug designation ... of fidaxomicin used to treat Clostridium difficile ...
Cached Medicine Technology:NxStage to Present at the 29th Annual J.P. Morgan Healthcare Conference 2Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 2Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 3Optimer Pharmaceuticals Receives Orphan Drug Designation for Fidaxomicin for the Treatment of Pediatric Clostridium difficile Infection 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: