Navigation Links
Single Drug Dose Cures Malaria in Mice

Johns Hopkins University researchers have cured malaria-infected mice with single shots of a new series of potent, long lasting synthetic drugs modeled on an ancient Chinese// herbal folk remedy. The team also has developed several other compounds, which defeated the febrile disease in rodents after three oral doses.

These peroxide compounds, containing a crucial oxygen-oxygen unit, promise not only to be more effective than today's best malaria remedies, but also potentially safer and more efficient, said research team leader Dr Gary Posner, Scowe Professor of chemistry in the Krieger School of Arts and Sciences at Johns Hopkins.

"We are disclosing, for the first time, the curative activity of a new generation of compounds that are long-lasting and therapeutic, even when used by themselves," Posner said. "Older drugs in this family of peroxide anti malarials also are known to be fast-acting, but they are unfortunately short-lived and not curative when used by themselves."

Though they say their results are very promising, the researchers caution that the new compounds must be thoroughly tested for safety and for how they are absorbed, distributed and metabolized in, and eliminated from, rodents' bodies before human tests begin.

Malaria afflicts between 300 million and 500 million people a year, killing between 1.5 million and 3 million, mostly children and mostly in developing nations. The most commonly fatal species of the malaria parasite now shows strong resistance to most current treatments, making the development of effective new drugs a worldwide priority.

Since 1992, Posner and his team, which includes collaborator Theresa Shapiro, Professor and Chair of clinical pharmacology at the Johns Hopkins School of Medicine, have been tackling that challenge by designing a series of peroxide compounds, called trioxanes.

"As a class, these compounds have proven to be unusually valuable in sev eral ways, from their brisk and potent antimalarial activity to their lack of resistance and cross-resistance with other antimalarial agents," Shapiro said.

The Johns Hopkins trioxanes mimic artemisinin, the active agent in a Chinese herbal drug used to treat malaria and other fevers for thousands of years. Artemisinin comes from the Artemisia annua plant, an herb also known by a variety of names including sweet wormwood.

Although the substance is inexpensive by Western standards, the widespread use of artemisinins in the developing world remains limited, in part by availability and the cost of separating the active ingredient from the Artemisia annua plant. Posner and his team contend that the potency and curative activity of their compounds provide "a substantially more efficient and economical use of the price-setting natural product."


Related medicine news :

1. Single gene analysis for diagnosis of a range of blood disorders
2. Single drug for bipolar disorder
3. Treating Testicular Cancer With A Single Dose Of Chemotherapy
4. Decreasing Multiple Births By Single Embryo Transfers
5. Single gene skin cancer cause
6. Drug Firms To Produce Single Pill AIDS Treatment
7. Malaria May Gain Resistance To Single Drug Prescriptions
8. Single Women with Baby Cravings Can Actually Cradle their Own, Courtesy NHS
9. Thai Doctors Removed 421 Kidney Stones From A Single Person
10. Single Dose Of Azithromycin Could Cure Trichiasis
11. Effects Of Certain Food Related To Single Pain Receptors
Post Your Comments:

(Date:11/30/2015)... ... , ... According to Los Angeles bariatric surgeon Michael Feiz, M.D., F.A.C.S., many ... real hunger, but instead by a hormone called ghrelin which (often prematurely) signals ... are aware that weight loss surgery can help patients lose weight by restricting the ...
(Date:11/30/2015)... Miami, FL (PRWEB) , ... November 30, 2015 ... ... added a comparison chart and ingredient list of its hemorrhoid ointment to its ... “fast, effective pain relief for people suffering from hemorrhoids. Adding the comparison chart ...
(Date:11/30/2015)... ... November 30, 2015 , ... Using a combination of two blood sugar tests ... adults, according to a new study by researchers at the School of Public Health ... Adults: Using Combinations of Blood Glucose Tests ,” published in Frontiers in Public Health, ...
(Date:11/30/2015)... ... November 30, 2015 , ... The recently ... Poison Data System (NPDS) reveals that in 2014, someone called a poison center ... two million of which were human exposure cases. , The American Association of ...
(Date:11/30/2015)... Reading, PA (PRWEB) , ... November 30, 2015 ... ... Ashland Specialty Ingredients (ASI) as their exclusive channel partner for the Nutraceutical Specialties ... supplements markets in the US, effective immediately. , “We are pleased to ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Next week, December 2-3, BIOMEDevice San ... co-located events covering the latest in Medtech innovation, Wearable ... draw more than 3,000 design industry professionals to the ... events, combined show floor will host more than 300 ... --> --> BIOMEDevice features suppliers in ...
(Date:11/30/2015)...  IBA Molecular North America, Inc. (IBAMNA), a U.S. ... that as of January 1, 2016, it will do ... to rebrand the company reflects a refined vision for ... close relationship with Zevacor Molecular.  Both IBAMNA and Zevacor ... Peter Burke , Vice President Sales ...
(Date:11/30/2015)... , Nov. 30, 2015 Nautilus Medical Inc. ... Image Management platform ( ). The release of ... from RSNA 2015 (Radiology Society North America) in ... in the U.S. --> ... that enables access to radiology studies worldwide via a ...
Breaking Medicine Technology: