Navigation Links
Single Cancer Stem Cell may Be Sufficient to Initiate and Maintain a Malignant Tumour

Nobel Laureate Dr. Renato Dulbecco has demonstrated that an injection of a single cell taken from cultured LA7 cells into mouse breast tissue can seed a new mammary carcinoma .

The results of the efforts of an international team of researchers led by Dr. Dulbecco, President Emeritus and Distinguished Resident Professor at the Salk Institute for Biological Studies, support the observation that though cancer stem cells are rare, in the bulk of a tumour, a single cancer stem cell is sufficient to initiate and maintain a malignant tumour.

We can use single cancer stem cells to study the dynamics and behaviour of cancer stem cells and their role in solid tumour formation at the single cell level, says lead author Dr. Ileana Zucchi, a molecular cancer biologist at the Institute for Biological Technology (ITB-CNR) in Milan, Italy.

The researchers believe that a model of cancer stem cell system may allow them to identify genes and proteins that will help with the search for human breast cancer stem cells in the future.

As we learn more about tumour formation at the single cell level in tissue, we may be able to specifically target cancer stem cells for destruction while leaving the normal stem cells in the body intact, hopes Zucchi.

The researchers say that it is well known that tumour cells and stem cells share many properties, which is characterised by their abilities to divide and generate both new stem cells and specialized cell types. However, there exists a major difference between the two.

Although normal stem cells show significant stem cell renewal, they are usually not associated with uncontrolled cell proliferation when they reside within their normal environment or niche. Cancer stem cells, however, are not equally responsive to environmental cues that repress uncontrolled cell proliferation of the stem cells, explains Zucchi.

With a view to assessing the LA7 cells tumorigenic potential, the researchers injected them into the breast tissue of female mice. They observed that unable to respond to conditions that prevent normal stem cells from spinning out of control, even a single LA7 cell started to form tumours.

If tumour induction was dependent on injecting more than one cell, it would be difficult to determine whether cells that appear to be resistant to these conditions are simply cell types different from cancer stem cells, Zucchi says.

But since we start with a single cancer stem cell for injection, we know that the resistance must derive from the original cancer stem cell, adds the researcher.


Related medicine news :

1. Single gene analysis for diagnosis of a range of blood disorders
2. Single drug for bipolar disorder
3. Treating Testicular Cancer With A Single Dose Of Chemotherapy
4. Decreasing Multiple Births By Single Embryo Transfers
5. Single gene skin cancer cause
6. Drug Firms To Produce Single Pill AIDS Treatment
7. Malaria May Gain Resistance To Single Drug Prescriptions
8. Single Women with Baby Cravings Can Actually Cradle their Own, Courtesy NHS
9. Thai Doctors Removed 421 Kidney Stones From A Single Person
10. Single Dose Of Azithromycin Could Cure Trichiasis
11. Effects Of Certain Food Related To Single Pain Receptors
Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is ... 2015, our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an ... every day excited to rebuild lives and it’s an honor to have served all ...
(Date:11/26/2015)... Karnataka (PRWEB) , ... November ... ... innovative online platform for mental health and wellness consultation, has collaborated with ... to holistically address their reader’s queries on topics on mental and emotional ...
(Date:11/25/2015)... ... November 25, 2015 , ... As part ... For Empowerment ™ attracts volunteers together who want to combine talents and resources ... key stakeholders in the process. The non-profit launched its first major fundraiser on ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... been recognized once again for its stellar workplace culture with the company’s Cincinnati ... , Medical Solutions’ Cincinnati office was named a finalist in Cincinnati Business ...
(Date:11/25/2015)... ... , ... Ministers, senior government and UN agencies, representatives from ... Excellence, and public R&D institutions, civil societies and other partners gathered today at ... Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- day meeting ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the European Therapeutic Drug Monitoring (TDM) ... Competitive Intelligence, Emerging Opportunities"  report to ... ) has announced the addition of ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
(Date:11/25/2015)... , Nov. 25, 2015 ... the addition of the "Global Brain ... their offering. --> ) ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) has ...
Breaking Medicine Technology: