Navigation Links
Simulated Heart Tissue Enhances Understanding of Arrhythmias And Defibrillator Failure

Cultured Heart cells that were induced to imitate characters of the heart have led researchers to discern possible reasons for irregular heart rhythms. Studies of // this engineered tissue have unraveled that while electric shocks akin to those produced by defibrillators normally stopped errant waves, in few cases caused them to advance and proliferate.

These findings have been reported on Feb 1, 2006, by the teams in The Duke University and Johns Hopkins University, headed by Nenad Bursac of Duke's Pratt School of Engineering and Cardiovascular Research. The experiments were conducted by Bursac and study co-author Leslie Tung at Johns Hopkins prior to Bursac joining the Duke faculty. National Institutes of Health and the American Heart Association have provided adequate support for this work. The experiments hovered around understanding Ventricular Tachycardia threadbare. Ventricular Tachycardia results when the heart’s pumping chambers produce abnormally fast paced beats, arrhythmias, especially when this condition gives rise to ventricular fibrillation. Ventricular fibrillation is a condition when the heart’s electrical activity becomes unsettled and disarranged, causing a ventricular flutter rather than concurrent beats. This can lead to ineffective pumping of blood that may result in sudden death.

According to Bursac, Ventricular Tachycardia and Fibrillation appear to be the commonest causes of sudden death in recent times. In his opinion, it would indeed call for a methodical study of arrhythmias owing to the complex anatomy in Humans and animals.

Bursac and his team used cells from the heart ventricles of neonatal rats to create an easier version of the heart tissue. These cells were then transferred into a culture dishes that contained requisite arrangement of proteins intended to support the growth of heart tissue. The proteins fuel the cells to multiply in a manner the imitates normal heart tissue. These simulated tissues wer e charged with electrical activity and attempts were made to curb it with pace-setting pulses. The team found that the pulses managed to arrest the wave in 80% of cases, while in the remaining cases a single wave multiplied into many waves that continued to catalyze the cardiac cells at a fast rate. In 20% of the cases, the purpose of actually ceasing the wave did not happen; in contrast it actually worsened the condition. This estimation almost matches the frequency of similar occurrences in patients with implanted defibrillators.

ICD devices render a potent shock when fast pulses mobilize tachycardia. Continued study of the engineered tissues could reveal further regarding better methods to arrest arrhythmias. The results have amply suggested the efficacy of using engineered tissue in studying the complex electrophysiological characteristics of the heart, according to Bursac. This would certainly hold the key to progressive drug and gene therapies purported to stabilize heart rhythms.

Source: Eureka Alert
'"/>




Related medicine news :

1. Surgeons Skilled in Playing Video Games are Good at Simulated Surgery
2. One in Three Heart Attack Patients Have No Chest Pains
3. Epileptic Seizures Can Be Due to Heart Problem
4. Bypass Heart Surgery Performed Without General Anesthesia
5. New CPR Guidelines issued by Heart Association
6. White Cells Count Can Predict Heart Attack Death Risk
7. Vitamins-The answer to Heart Disease?
8. Fight Heart disease and Pain with Meditation
9. Heart disease in the newborn is related to maternal malnutrition
10. New drug to treat Heart Attack and damaged tissue
11. Heart disease threat starts early in life for Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... Raton, FL (PRWEB) , ... January 20, 2017 ... ... nutritional and wellness products to enhance people’s everyday lives, recently attended the January ... retail buyers. , ATP Science is known for its large range of supplements ...
(Date:1/20/2017)... York, NY (PRWEB) , ... January 20, 2017 ... ... – VW+ 001 and its sugar-free alternative VW+ 002. The drinks have been ... body with optimal conditions to perform during your workout. , After a successful ...
(Date:1/20/2017)... ... ... Forgive You”: a fine examination of how God handles sin, including how to let ... Stephen Miller, who, for over ten long years has been waiting to release this powerful ... Tobago, he has been serving the Lord for over twenty years, and he has been ...
(Date:1/20/2017)... ... 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and colorful ... Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, and ... “I have been writing since high school and have many different titles,” Gaapf mentions ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... System: an On-demand E-learning system for Clinical and Regulatory education for Physicians, ... based on Aerolib`s successful education methodology of Disease Specific Documentation Improvement. , ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... January 19, 2017 Incretin Mimetics/GLP-1 Agonists, SNDRIs, ... The global anti-obesity drugs market is expected ... of the forecast period and CAGR of 38.7% in the second ... at a CAGR of 32.8% from 2016 to 2027. The market ... and $24,063 million in 2027. ...
(Date:1/19/2017)... , Jan. 19, 2017 Accuray Incorporated (Nasdaq: ... and TomoTherapy® Systems continue to set the bar for ... highest composite overall user satisfaction rating among radiation treatment ... 2016 MD Buyline Market Intelligence Briefing™. The most recent ... composite ratings among industry peers for 11 of the ...
(Date:1/19/2017)... 2017 James Gilbart ... Haematology, 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... Published recently in a supplement to European Oncology ... an article by James Gilbart and ...
Breaking Medicine Technology: