Navigation Links
Simulated Heart Tissue Enhances Understanding of Arrhythmias And Defibrillator Failure

Cultured Heart cells that were induced to imitate characters of the heart have led researchers to discern possible reasons for irregular heart rhythms. Studies of // this engineered tissue have unraveled that while electric shocks akin to those produced by defibrillators normally stopped errant waves, in few cases caused them to advance and proliferate.

These findings have been reported on Feb 1, 2006, by the teams in The Duke University and Johns Hopkins University, headed by Nenad Bursac of Duke's Pratt School of Engineering and Cardiovascular Research. The experiments were conducted by Bursac and study co-author Leslie Tung at Johns Hopkins prior to Bursac joining the Duke faculty. National Institutes of Health and the American Heart Association have provided adequate support for this work. The experiments hovered around understanding Ventricular Tachycardia threadbare. Ventricular Tachycardia results when the heart’s pumping chambers produce abnormally fast paced beats, arrhythmias, especially when this condition gives rise to ventricular fibrillation. Ventricular fibrillation is a condition when the heart’s electrical activity becomes unsettled and disarranged, causing a ventricular flutter rather than concurrent beats. This can lead to ineffective pumping of blood that may result in sudden death.

According to Bursac, Ventricular Tachycardia and Fibrillation appear to be the commonest causes of sudden death in recent times. In his opinion, it would indeed call for a methodical study of arrhythmias owing to the complex anatomy in Humans and animals.

Bursac and his team used cells from the heart ventricles of neonatal rats to create an easier version of the heart tissue. These cells were then transferred into a culture dishes that contained requisite arrangement of proteins intended to support the growth of heart tissue. The proteins fuel the cells to multiply in a manner the imitates normal heart tissue. These simulated tissues wer e charged with electrical activity and attempts were made to curb it with pace-setting pulses. The team found that the pulses managed to arrest the wave in 80% of cases, while in the remaining cases a single wave multiplied into many waves that continued to catalyze the cardiac cells at a fast rate. In 20% of the cases, the purpose of actually ceasing the wave did not happen; in contrast it actually worsened the condition. This estimation almost matches the frequency of similar occurrences in patients with implanted defibrillators.

ICD devices render a potent shock when fast pulses mobilize tachycardia. Continued study of the engineered tissues could reveal further regarding better methods to arrest arrhythmias. The results have amply suggested the efficacy of using engineered tissue in studying the complex electrophysiological characteristics of the heart, according to Bursac. This would certainly hold the key to progressive drug and gene therapies purported to stabilize heart rhythms.

Source: Eureka Alert
'"/>




Related medicine news :

1. Surgeons Skilled in Playing Video Games are Good at Simulated Surgery
2. One in Three Heart Attack Patients Have No Chest Pains
3. Epileptic Seizures Can Be Due to Heart Problem
4. Bypass Heart Surgery Performed Without General Anesthesia
5. New CPR Guidelines issued by Heart Association
6. White Cells Count Can Predict Heart Attack Death Risk
7. Vitamins-The answer to Heart Disease?
8. Fight Heart disease and Pain with Meditation
9. Heart disease in the newborn is related to maternal malnutrition
10. New drug to treat Heart Attack and damaged tissue
11. Heart disease threat starts early in life for Diabetics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: