Navigation Links
Simple Urine Test Can Help To Monitor Disfiguring Birthmarks,,

Research from Children's Hospital Boston suggests that a urine test can help in both monitoring and predicting // vascular anomalies. The study also raises the possibility of treating these with anti-angiogenesis drugs

The July issue of the journal - Pediatrics, has published an article about vascular anomalies in children. Vascular anomalies can be found in about 10% of newly born infants and include both vascular malformations and vascular tumors.

These occur when the cells lining blood vessels multiply abnormally, forming clusters of vessels and then they are also called – Hemangiomas. They can grow rapidly in the first year of life, then usually shrink and disappear. But some grow quite large, causing obstruction, ulceration and other problems.

Marsha Moses, PhD of Children's Vascular Biology Program, senior investigator on the study, had been studying the matrix metalloproteinases (MMPs), a family of enzymes required for angiogenesis, or growth of new blood vessels.

Angiogenesis is also critical to a cancer's expansion, and Moses' lab was the first to show that inhibitors of MMP can inhibit angiogenesis. Recently, her lab also demonstrated that cancer patients have elevated levels of MMPs in their urine. Because vascular anomalies like hemangiomas also involve angiogenesis.

Moses, Marler and colleagues tested the urine of 217 patients with vascular anomalies and 74 healthy controls of the same age and tested it for MMP . A subgroup of MMPs – known as the high-molecular-weight MMPs – were elevated in the urine of 53 percent of patients with vascular tumors and 41 percent of those with vascular malformations, but in only 22 percent of controls.

Vascular anomalies were also associated with elevated urine levels of basic fibroblast growth factor (bFGF), another compound that promotes angiogenesis. Increased urine levels of MMPs and bFGF correlated with both the extent and progression of vascular anomalies. The new findings suggest, for the first time, that angiogenesis also plays a role in the progression of vascular malformations, raising the possibility of curbing these difficult-to-treat anomalies with anti-angiogenic drugs, in particular MMP inhibitors.

Current treatment for vascular malformations consists of surgery, embolization or sclerotherapy, which can be dangerous, deforming, or produce unsatisfactory results.

Children's Hospital Boston researchers have in 1980 already showed that growth of hemangiomas is known to be angiogenesis-dependent and can be suppressed with anti-angiogenic drugs –currently, corticosteroids and vincristine. "Prior to this study, we had thought it was not possible to treat vascular malformations with drugs, since congenital anomalies generally do not respond to drugs," says Steven Fishman, MD, a surgeon on Children's Vascular Anomalies team. "This study gives us hope that with further research we'll be able to develop drug treatments."

Urine testing for MMPs may help physicians know when a vascular anomaly is about to become aggressive and needs intervention. "It can be very hard to tell whether an anomaly will progress," Fishman says. "It can sit there and do nothing, or go on to destroy the nose or other nearby tissues. What we've shown that the presence of MMPs in urine correlates with how aggressive the lesions are."

News Extract from - http://www.childrenshospital.org/research/. Contact: Elizabeth Andrews elizabeth.andrews@childrens.harvard.edu 617-355-6420 Children's Hospital Boston
'"/>




Related medicine news :

1. Long-Term Survival can be Predicted by a Simple Lung Test
2. Simple Therapy
3. Simple Stroke Prevention is Best
4. Few Simple Steps to Lower The Incidence Of SIDS
5. A Simple Blood Test Can Predict Gum Disease
6. A Simple Exercise Can Uncover Undiagnosed Asthma
7. Simple Exercises Might Help Vertigo
8. Simple Steps To Help Fight Asthma
9. Revolutionary Simple Pregnancy Blood Test Can Save Both Mother And Child
10. Simple Procedural Improvements Can Improve Care Of Stroke Patients
11. Simplest therapeutic regimen found less effective against HIV
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm ... California Berkeley, and other leading institutions in announcing the launch of the ... change the way animals are raised for food. , Founding members of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... Nvision ... executive staff with the addition of industry sales leader, Thomas (Tom) Slott, as ... the national distribution and sales network, direct the efforts of the surgical sales ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
Breaking Medicine Technology: