Navigation Links
Simple Urine Test Can Help To Monitor Disfiguring Birthmarks,,

Research from Children's Hospital Boston suggests that a urine test can help in both monitoring and predicting // vascular anomalies. The study also raises the possibility of treating these with anti-angiogenesis drugs

The July issue of the journal - Pediatrics, has published an article about vascular anomalies in children. Vascular anomalies can be found in about 10% of newly born infants and include both vascular malformations and vascular tumors.

These occur when the cells lining blood vessels multiply abnormally, forming clusters of vessels and then they are also called – Hemangiomas. They can grow rapidly in the first year of life, then usually shrink and disappear. But some grow quite large, causing obstruction, ulceration and other problems.

Marsha Moses, PhD of Children's Vascular Biology Program, senior investigator on the study, had been studying the matrix metalloproteinases (MMPs), a family of enzymes required for angiogenesis, or growth of new blood vessels.

Angiogenesis is also critical to a cancer's expansion, and Moses' lab was the first to show that inhibitors of MMP can inhibit angiogenesis. Recently, her lab also demonstrated that cancer patients have elevated levels of MMPs in their urine. Because vascular anomalies like hemangiomas also involve angiogenesis.

Moses, Marler and colleagues tested the urine of 217 patients with vascular anomalies and 74 healthy controls of the same age and tested it for MMP . A subgroup of MMPs – known as the high-molecular-weight MMPs – were elevated in the urine of 53 percent of patients with vascular tumors and 41 percent of those with vascular malformations, but in only 22 percent of controls.

Vascular anomalies were also associated with elevated urine levels of basic fibroblast growth factor (bFGF), another compound that promotes angiogenesis. Increased urine levels of MMPs and bFGF correlated with both the extent and progression of vascular anomalies. The new findings suggest, for the first time, that angiogenesis also plays a role in the progression of vascular malformations, raising the possibility of curbing these difficult-to-treat anomalies with anti-angiogenic drugs, in particular MMP inhibitors.

Current treatment for vascular malformations consists of surgery, embolization or sclerotherapy, which can be dangerous, deforming, or produce unsatisfactory results.

Children's Hospital Boston researchers have in 1980 already showed that growth of hemangiomas is known to be angiogenesis-dependent and can be suppressed with anti-angiogenic drugs –currently, corticosteroids and vincristine. "Prior to this study, we had thought it was not possible to treat vascular malformations with drugs, since congenital anomalies generally do not respond to drugs," says Steven Fishman, MD, a surgeon on Children's Vascular Anomalies team. "This study gives us hope that with further research we'll be able to develop drug treatments."

Urine testing for MMPs may help physicians know when a vascular anomaly is about to become aggressive and needs intervention. "It can be very hard to tell whether an anomaly will progress," Fishman says. "It can sit there and do nothing, or go on to destroy the nose or other nearby tissues. What we've shown that the presence of MMPs in urine correlates with how aggressive the lesions are."

News Extract from - Contact: Elizabeth Andrews 617-355-6420 Children's Hospital Boston

Related medicine news :

1. Long-Term Survival can be Predicted by a Simple Lung Test
2. Simple Therapy
3. Simple Stroke Prevention is Best
4. Few Simple Steps to Lower The Incidence Of SIDS
5. A Simple Blood Test Can Predict Gum Disease
6. A Simple Exercise Can Uncover Undiagnosed Asthma
7. Simple Exercises Might Help Vertigo
8. Simple Steps To Help Fight Asthma
9. Revolutionary Simple Pregnancy Blood Test Can Save Both Mother And Child
10. Simple Procedural Improvements Can Improve Care Of Stroke Patients
11. Simplest therapeutic regimen found less effective against HIV
Post Your Comments:

(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from reveals that behind the tendency ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
Breaking Medicine Technology: