( rapy alone. The researchers also ...)Significant Advance in Treatment of Breast Cancer Reported,Health

rapy alone.

The researchers also demonstrated that tipifarnib inhibited farnesyltransferase in tumor tissue by an average of 90 percent. Farnesyltransferase is essential for activating proteins, such as one called Ras, that contribute to the growth of cancer cells.

"This important study suggests that the proliferation and survival of breast tumor cells from one third of the patients in our study depended on proteins that were activated by farnesyltransferase," said Dr. Said Sebti, coauthor of the study and associate director of the Moffitt Research Institute in Tampa, Florida.

"We believe that by switching off the farnesylation-dependent pathways we made the chemotherapy much more effective" said Dr. Sparano. "Our next step will be to combine tipifarnib with other types of standard chemotherapy in order to push the response rate even higher, and perform randomized trials that provide more definitive proof of the benefits of this treatment."

The trial was performed by the New York Cancer Consortium, a multicenter clinical trials group funded by the National Cancer Institute to evaluate the newest and most promising cancer treatments. Montefiore Medical Center is the lead institution for this group. Each year, approximately 200 patients are enrolled in clinical trials conducted by the Consortium. The work was also partially funded by a grant from the National Cancer Institute to Dr. Septi.

Montefiore Medical Center, The University Hospital and Academic Medical Center for the Albert Einstein College of Medicine, ranks among the top one percent of all US hospitals based on its investments in medical innovation and cutting-edge technology.

(Source: Newswise)
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