Navigation Links
Short Stature Can Be Treated With A New, Non-Growth Hormone In Future

Insulin-like Growth Factor-1 (IGF-1) is an important hormone necessary for statural growth and must be present in order for children's bones, cartilage and organs to grow normally. In healthy individuals, growth hormone is // secreted into the bloodstream by the pituitary gland that binds to growth hormone receptors on liver and other cells, where it stimulates the cellular production and secretion of IGF-1 into the bloodstream.

Any defect in the above mentioned pathway can lead to growth failure and short stature. Supplementation with human growth hormone is the currently available method for management of the condition. However, patients who are deficient in IGF-1 and resistant to the effects of growth hormone do not respond well to the treatment.

Primary IGFD afflicts an estimated 30,000 children evaluated for short stature in the United States. A child with short stature is defined as being shorter than 97.5 percent of all children the same age and gender.

If untreated, primary IGFD may lead, in children and adults, to a range of other metabolic disorders, including lipid abnormalities, decreased bone density, obesity, and insulin resistance.

A clinical trial aiming at replacing IGF-1 directly rather than using growth hormone to stimulate the production has been initiated. The drug, called Increlex, was approved by the FDA August 31 for the most severe form of short stature due to a deficiency of Insulin-like Growth Factor-1 (IGF-1).

Increlex is a genetically engineered copy of IGF-1. The purified protein has been shown to be structurally and functionally identical to natural human IGF-1. It is injected daily before a meal to provide the catalyst the body needs to grow.

Ongoing clinical trails would be directed towards assessment the efficacy, safety and tolerability of the drug over the conventional treatment.
'"/>




Page: 1

Related medicine news :

1. Bad News for Short People
2. Painkillers Do Not Shorten Dying Patients Lives
3. Short stature -a problem
4. Shortage of MMR vaccine
5. Short stature -a problem
6. Shorter infants have lower incomes in later life
7. Eye Disorders, A Predictor Of A Shorter Lifespan
8. Shorter Radiation Schedules Found To Be More Effective For Patients With Breast Cancer
9. Short term hormone replacement therapy effective
10. New Eye Surgery Gives Hope To Short-Sighted
11. Short Workouts May Not Prevent Weight Gain And Diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... April 30, 2016 , ... Create an abstract shape animation ... and manipulate three-dimensional shapes with ease all within Apple Motion . Users ... polygon texture animation, opacity texture animation, overall shape texture displacement, twist, camera controls, ...
(Date:4/30/2016)... Austin, Texas (PRWEB) , ... April 30, 2016 ... ... time to celebrate the profession and recognize veterinarians’ global impact on public health. ... choose a theme each year, and this year have selected continuing education with ...
(Date:4/30/2016)... Santa Rosa, CA (PRWEB) , ... April 30, 2016 , ... “Aging well is a challenge for all of us, ... says NCMA’s Dr. Parul T. Kohli . “Research is showing more and more that ... the risk of disease and disability as we age.” Top priorities Dr. Kohli’s recommends for her ...
(Date:4/29/2016)... ... 2016 , ... Mercy College is expanding its Graduate Business Programs to the ... due to high demand: Master of Business Administration (MBA), Master of Organizational Leadership (MSOL) ... , School of Business Graduate Program Chair Dr. Ray Manganelli said: “We believe that ...
(Date:4/29/2016)... ... April 29, 2016 , ... Memorial Healthcare System Graduate ... Education (ACGME) that it has received accreditation for its residency program on Physical ... programs that Memorial is currently pursuing, including Pediatrics and Internal Medicine. This accreditation ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016 The ... USD 2.06 billion by 2022, according to a ... consumer awareness towards a healthy lifestyle is expected ... years.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ... with rising health treatment expenditure has urged consumers ...
(Date:4/26/2016)... Mich. , April 26, 2016 Diplomat ... promotion of Jennifer Hagerman , Pharm D., to ... her growing role at Diplomat, Hagerman will continue to ... the company that delivers custom education and training to ... the specialty pharmacy industry. Diplomat University also houses the ...
(Date:4/26/2016)... , April 26, 2016 US demand ... to expand 4.9 percent annually to $27.6 billion ... healthcare facilities to decrease rates of healthcare-associated infections ... supplies, equipment, and services.  Although declining, the overall ... above targeted levels set by the CDC.  Recent ...
Breaking Medicine Technology: