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Shire Developed DAYTRANA – The First Medication to Treat ADHD Symptom

sor of psychiatry, University of Pittsburgh School of Medicine. ‘Because not all children with ADHD are the same and because a child's schedule may vary from day to day, parents and patients may benefit from the individualized management of a patient's ADHD symptoms that DAYTRANA provides. DAYTRANA is a valuable new tool in the treatment of ADHD.’

DAYTRANA Significantly Controls ADHD symptoms

Data from phase II and phase III clinical trials demonstrated statistically significant improvements in the primary and secondary endpoints analyzed for children aged 6-12 years treated with DAYTRANA compared to children treated with placebo.

The phase II analog classroom study included 79 children with ADHD. The patch was worn for nine hours, and significant efficacy was demonstrated at the first time point measured, two hours after patch application, and throughout the day for 12 hours. The participants treated with DAYTRANA demonstrated statistically significant improvement over placebo on the measures tested. Behavior, which was measured using the Swanson, Kotkin, Agler, M-Flynn, and Pelham-Deportment (SKAMP-D) scale, in which higher ratings reflect greater impairment, was improved with DAYTRANA overall (mean score 3.2 for DAYTRANA versus 8.0 for placebo) and at all time points assessed throughout the day (P < .01). Children taking DAYTRANA also attempted more math questions on the Permanent Product Measure of Performance (PERMP) scale than those taking placebo (114 versus 87, respectively) and completed more math problems correctly than did those taking placebo (110 versus 81, respectively).

In the phase III naturalistic trial with 270 participants, investigators found that DAYTRANA worn for nine hours reduced the children's overall symptoms of ADHD, compared to a placebo (P < .0001), as measured by scores1 on the ADHD Rating Scale (ADHD-RS-IV), in which higher scores reflect greater impairment. By the study's end, mean ADHD-RS-IV sc
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