Navigation Links
Sex Determination Gene Blamed For High Incidence Of Parkinson’s In Me

The SRY or the sex determination gene, that plays a crucial role in deciding if an embryo should develop into a male or female (embryo with SRY gene develops into a male), could explain the high incidence of Parkinson's disease in men. // The SRY protein, required for formation of testes is also produced by Parkinson's affected areas in the brain, report researchers from Prince Henry's Institute and University of California.

The SRY gene was discovered in 1990 and is present only in the male. The gene is transmitted from father to son and is not present in females. It could contribute to different aspects related to control of physical movement and brain function, according to Vincent Harley, one of the senior researchers. Clearly, more research is needed to better understand the role of SRY gene in co-ordination of body movements.

Parkinson's disease is a chronic disease characterized movement disorder and affects nearly 40,000 Australians. It is 1.5 times more likely to occur in men compared to women. The disease is associated with an earlier age of onset in one out of seven Parkinson's sufferers and is highly variable in terms of symptoms and disease progression. There is no proper available cure or treatment for this disease. Surgery and medication may be of limited help.

A region of the brain called substantia nigra, has been found to secrete small amount of the SRY protein. It is this region of the brain that deteriorates in Parkinson's disease patients.

With death of cells in the substantia nigra, there is less production of dopamine that signals the brain regarding co-ordination and movement of the body parts. As a consequence, patients lose their ability to initiate or have control over their body movements and eventually end up with paralysis.

The research team analyzed the effects of low SRY protein levels in animals designed to mimic human models of Parkinson's disease. Parkinson's-like movement problems in animals were manifested in animals with low SRY level in the substantia nigra of animal brain.

'We were surprised to find a function for SRY outside the testes. The SRY gene may also explain the sex differences in other dopamine-linked disorders with a higher incidence in males, such as schizophrenia or addiction,' remarked the researchers.

Following this finding, the researchers hypothesize that men with low SRY levels could face an increased risk of developing Parkinson's disease. Furthermore, genetic variations in the SRY gene could confer an increased or decreased susceptibility to the disease. With improved understanding of such genetic mechanisms, it might be possible to identify at-risk individuals at an early stage.


'"/>




Related medicine news :

1. Punjab Government To Clamp Down On Sex Determination Tests
2. Doctor Caught Red-Handed For Conducting Sex-Determination Test
3. NHRC Demands Report From Govt Of Rajasthan On Sex Determination Tests
4. Punjab Plans of Banning Sex Determination Kit from US
5. Sex Determination Test Informers to be Rewarded
6. Pet Project: Dogged Determination to Rid Vienna of Ubiquitous Dog Droppings
7. Gender-Benders: Sports and Sex Determination
8. Madhya Pradesh Gets Tough on Sex Determination Tests
9. Now Sex Determination of Fetuses in Six Weeks in UK
10. Green Onions Blamed in Outbreak
11. Women Poorly Informed About Contraceptive Options: Doctors Blamed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will ... the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey ... Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017   Divoti USA ... Jewelry up to the standard of the latest FDA requirements, which ... 2017). Anyone in need of Medical ID jewelry such ... Alert Jewelry are engraved in terms of the new ... Divoti offers ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
Breaking Medicine Technology: