Navigation Links
Sex Determination Gene Blamed For High Incidence Of Parkinson’s In Me

The SRY or the sex determination gene, that plays a crucial role in deciding if an embryo should develop into a male or female (embryo with SRY gene develops into a male), could explain the high incidence of Parkinson's disease in men. // The SRY protein, required for formation of testes is also produced by Parkinson's affected areas in the brain, report researchers from Prince Henry's Institute and University of California.

The SRY gene was discovered in 1990 and is present only in the male. The gene is transmitted from father to son and is not present in females. It could contribute to different aspects related to control of physical movement and brain function, according to Vincent Harley, one of the senior researchers. Clearly, more research is needed to better understand the role of SRY gene in co-ordination of body movements.

Parkinson's disease is a chronic disease characterized movement disorder and affects nearly 40,000 Australians. It is 1.5 times more likely to occur in men compared to women. The disease is associated with an earlier age of onset in one out of seven Parkinson's sufferers and is highly variable in terms of symptoms and disease progression. There is no proper available cure or treatment for this disease. Surgery and medication may be of limited help.

A region of the brain called substantia nigra, has been found to secrete small amount of the SRY protein. It is this region of the brain that deteriorates in Parkinson's disease patients.

With death of cells in the substantia nigra, there is less production of dopamine that signals the brain regarding co-ordination and movement of the body parts. As a consequence, patients lose their ability to initiate or have control over their body movements and eventually end up with paralysis.

The research team analyzed the effects of low SRY protein levels in animals designed to mimic human models of Parkinson's disease. Parkinson's-like movement problems in animals were manifested in animals with low SRY level in the substantia nigra of animal brain.

'We were surprised to find a function for SRY outside the testes. The SRY gene may also explain the sex differences in other dopamine-linked disorders with a higher incidence in males, such as schizophrenia or addiction,' remarked the researchers.

Following this finding, the researchers hypothesize that men with low SRY levels could face an increased risk of developing Parkinson's disease. Furthermore, genetic variations in the SRY gene could confer an increased or decreased susceptibility to the disease. With improved understanding of such genetic mechanisms, it might be possible to identify at-risk individuals at an early stage.


'"/>




Related medicine news :

1. Punjab Government To Clamp Down On Sex Determination Tests
2. Doctor Caught Red-Handed For Conducting Sex-Determination Test
3. NHRC Demands Report From Govt Of Rajasthan On Sex Determination Tests
4. Punjab Plans of Banning Sex Determination Kit from US
5. Sex Determination Test Informers to be Rewarded
6. Pet Project: Dogged Determination to Rid Vienna of Ubiquitous Dog Droppings
7. Gender-Benders: Sports and Sex Determination
8. Madhya Pradesh Gets Tough on Sex Determination Tests
9. Now Sex Determination of Fetuses in Six Weeks in UK
10. Green Onions Blamed in Outbreak
11. Women Poorly Informed About Contraceptive Options: Doctors Blamed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2016)... ... April 30, 2016 , ... Orlando-based Maximized Living has selected Dr. ... gold in Rio. Under the care of Maximized Living doctors at the London ... unprecedented showing, Maximized Living is sending the largest contingent of elite chiropractors to Rio ...
(Date:4/29/2016)... ... April 29, 2016 , ... Memorial Healthcare System Graduate ... Education (ACGME) that it has received accreditation for its residency program on Physical ... programs that Memorial is currently pursuing, including Pediatrics and Internal Medicine. This accreditation ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... and author of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related ... 2016 and podcasted thereafter . Dr. Bernie Siegel, author of a plethora ...
(Date:4/29/2016)... ... April 29, 2016 , ... Spine Team Texas, a comprehensive spine physician ... one of their physicians has been invited to be a featured speaker at the ... Review conference on April 30, 2016. , Dr. R. Scott McPherson, a physical ...
(Date:4/29/2016)... ... 29, 2016 , ... Melanoma is the deadliest type of skin cancer. Although only about 1 ... skin cancer deaths. More than 10,000 people are expected to die of melanoma this year. ... is the one of the most commonly diagnosed cancers in young women. A recent breakthrough ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016 Tie-up with Government hospitals ... to save newborns   Fortis La Femme, ... in collaboration with Breast Milk Foundation (BMF), a non-profit organization ... Milk Bank, ,Amaara, in Delhi-NCR today. This non-profit centre recognizes ... infants and should be available to babies deprived of mother,s ...
(Date:4/27/2016)... 2016 Oasmia Pharmaceutical AB ... a new generation of drugs within human and ... for Paclical/Apealea in the Phase III study that ... ovarian cancer. These preliminary results showed non-inferiority between ... carboplatin versus Taxol in combination with carboplatin. In ...
(Date:4/26/2016)... FLINT, Mich. , April 26, 2016 ... the promotion of Jennifer Hagerman , Pharm D., ... In her growing role at Diplomat, Hagerman will continue ... of the company that delivers custom education and training ... to the specialty pharmacy industry. Diplomat University also houses ...
Breaking Medicine Technology: