Navigation Links
Sex Determination Gene Blamed For High Incidence Of Parkinson’s In Me

The SRY or the sex determination gene, that plays a crucial role in deciding if an embryo should develop into a male or female (embryo with SRY gene develops into a male), could explain the high incidence of Parkinson's disease in men. // The SRY protein, required for formation of testes is also produced by Parkinson's affected areas in the brain, report researchers from Prince Henry's Institute and University of California.

The SRY gene was discovered in 1990 and is present only in the male. The gene is transmitted from father to son and is not present in females. It could contribute to different aspects related to control of physical movement and brain function, according to Vincent Harley, one of the senior researchers. Clearly, more research is needed to better understand the role of SRY gene in co-ordination of body movements.

Parkinson's disease is a chronic disease characterized movement disorder and affects nearly 40,000 Australians. It is 1.5 times more likely to occur in men compared to women. The disease is associated with an earlier age of onset in one out of seven Parkinson's sufferers and is highly variable in terms of symptoms and disease progression. There is no proper available cure or treatment for this disease. Surgery and medication may be of limited help.

A region of the brain called substantia nigra, has been found to secrete small amount of the SRY protein. It is this region of the brain that deteriorates in Parkinson's disease patients.

With death of cells in the substantia nigra, there is less production of dopamine that signals the brain regarding co-ordination and movement of the body parts. As a consequence, patients lose their ability to initiate or have control over their body movements and eventually end up with paralysis.

The research team analyzed the effects of low SRY protein levels in animals designed to mimic human models of Parkinson's disease. Parkinson's-like movement problems in animals were manifested in animals with low SRY level in the substantia nigra of animal brain.

'We were surprised to find a function for SRY outside the testes. The SRY gene may also explain the sex differences in other dopamine-linked disorders with a higher incidence in males, such as schizophrenia or addiction,' remarked the researchers.

Following this finding, the researchers hypothesize that men with low SRY levels could face an increased risk of developing Parkinson's disease. Furthermore, genetic variations in the SRY gene could confer an increased or decreased susceptibility to the disease. With improved understanding of such genetic mechanisms, it might be possible to identify at-risk individuals at an early stage.


'"/>




Related medicine news :

1. Punjab Government To Clamp Down On Sex Determination Tests
2. Doctor Caught Red-Handed For Conducting Sex-Determination Test
3. NHRC Demands Report From Govt Of Rajasthan On Sex Determination Tests
4. Punjab Plans of Banning Sex Determination Kit from US
5. Sex Determination Test Informers to be Rewarded
6. Pet Project: Dogged Determination to Rid Vienna of Ubiquitous Dog Droppings
7. Gender-Benders: Sports and Sex Determination
8. Madhya Pradesh Gets Tough on Sex Determination Tests
9. Now Sex Determination of Fetuses in Six Weeks in UK
10. Green Onions Blamed in Outbreak
11. Women Poorly Informed About Contraceptive Options: Doctors Blamed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
Breaking Medicine Technology: