Navigation Links
Sex Determination Gene Blamed For High Incidence Of Parkinson’s In Me

The SRY or the sex determination gene, that plays a crucial role in deciding if an embryo should develop into a male or female (embryo with SRY gene develops into a male), could explain the high incidence of Parkinson's disease in men. // The SRY protein, required for formation of testes is also produced by Parkinson's affected areas in the brain, report researchers from Prince Henry's Institute and University of California.

The SRY gene was discovered in 1990 and is present only in the male. The gene is transmitted from father to son and is not present in females. It could contribute to different aspects related to control of physical movement and brain function, according to Vincent Harley, one of the senior researchers. Clearly, more research is needed to better understand the role of SRY gene in co-ordination of body movements.

Parkinson's disease is a chronic disease characterized movement disorder and affects nearly 40,000 Australians. It is 1.5 times more likely to occur in men compared to women. The disease is associated with an earlier age of onset in one out of seven Parkinson's sufferers and is highly variable in terms of symptoms and disease progression. There is no proper available cure or treatment for this disease. Surgery and medication may be of limited help.

A region of the brain called substantia nigra, has been found to secrete small amount of the SRY protein. It is this region of the brain that deteriorates in Parkinson's disease patients.

With death of cells in the substantia nigra, there is less production of dopamine that signals the brain regarding co-ordination and movement of the body parts. As a consequence, patients lose their ability to initiate or have control over their body movements and eventually end up with paralysis.

The research team analyzed the effects of low SRY protein levels in animals designed to mimic human models of Parkinson's disease. Parkinson's-like movement problems in animals were manifested in animals with low SRY level in the substantia nigra of animal brain.

'We were surprised to find a function for SRY outside the testes. The SRY gene may also explain the sex differences in other dopamine-linked disorders with a higher incidence in males, such as schizophrenia or addiction,' remarked the researchers.

Following this finding, the researchers hypothesize that men with low SRY levels could face an increased risk of developing Parkinson's disease. Furthermore, genetic variations in the SRY gene could confer an increased or decreased susceptibility to the disease. With improved understanding of such genetic mechanisms, it might be possible to identify at-risk individuals at an early stage.


'"/>




Related medicine news :

1. Punjab Government To Clamp Down On Sex Determination Tests
2. Doctor Caught Red-Handed For Conducting Sex-Determination Test
3. NHRC Demands Report From Govt Of Rajasthan On Sex Determination Tests
4. Punjab Plans of Banning Sex Determination Kit from US
5. Sex Determination Test Informers to be Rewarded
6. Pet Project: Dogged Determination to Rid Vienna of Ubiquitous Dog Droppings
7. Gender-Benders: Sports and Sex Determination
8. Madhya Pradesh Gets Tough on Sex Determination Tests
9. Now Sex Determination of Fetuses in Six Weeks in UK
10. Green Onions Blamed in Outbreak
11. Women Poorly Informed About Contraceptive Options: Doctors Blamed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... , ... December 07, 2016 , ... ... Dallas, Texas, is condemning "scam operations" carried out by unethical locksmith companies and ... scam operations to a halt. According to Texas Premier Locksmith, these fraudulent locksmith ...
(Date:12/7/2016)... Ohio (PRWEB) , ... December 07, 2016 , ... ... in the 2016 BOC Business Brilliance Awards under the Best New Product Launch ... and results achieved through user experience. , BOC Global Events & Training Group ...
(Date:12/7/2016)... ... 07, 2016 , ... “Tomorrow Trump Goes To Washington”: a brief but ... presidency and to America. “Tomorrow Trump Goes To Washington” is the creation of published ... for this country. , Nancy attributes her patriotic nature to her WWII veteran father. ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... the fifth annual Business Architecture Innovation Summit in Reston, VA on March 21-22, ... who will share a range of experiences from a cross-section of industries such ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... networks that can be seen on a type of MRI, according to a ... progressive disorder of the central nervous system characterized by tremors or trembling and ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... bringing their 100% all-natural lice removal service to Brooklyn ... th Street was specifically chosen to make treatment convenient for ... is to ease parents, stress and bring their lives back under ... to class without skipping a beat. The best part is that ... family," Licenders President Adie Horowitz states. ...
(Date:12/6/2016)... LONDON , Dec. 6, 2016 Diabetes ... The diabetes and obesity disease cluster is currently ... (T1DM) and type 2 diabetes mellitus (T2DM), and the ... and quality of products, is attributable to these indications. ... a large market presence, there are a large number ...
(Date:12/6/2016)... , Dec. 6, 2016 Human Vaccines ... in-depth region wise and country wise analysis of ... include manufacturers of human vaccines products, raw material ... to enter the market. The report provides ... vaccines market. Qualitative analysis comprises market dynamics, trends, ...
Breaking Medicine Technology: