Navigation Links
Sequencing of the Plague

Bubonic plague, the bacterium blamed for the Black Death during middle ages in Europe and now a potential biological weapon, has had its entire genome sequenced. The genes seem to be "unusually fluid", readily re-arranging themselves and picking up new genes from other microbes. That could mean that more virulent strains of plague might emerge. More ominously, it suggests that enhanced strains might be relatively easy to develop as weapons.

The bacillus that causes bubonic plague, Yersinia pestis, commonly infects rodents in Asia, Africa and the Americas. But it occasionally spreads to humans, with fatal effect.It does so by infecting both insects and mammals. Fleas that feed on infected rodents swallow the bacteria, which infect and block their midguts. The starving fleas feed ravenously, but only regurgitate the blood they try to swallow - along with the bacteria. So plague spreads among rodents, often causing only mild disease.//

If the infected flea bites a human, however, up to half the victims die, unless treated with antibiotics. If the bacteria invade the lungs of such patients, and they cough them out, nearby people may catch "pneumonic" plague. This is always fatal without treatment.

Pneumonic plague is the form feared as a latent biological weapon, as it can be released as an aerosol and can spread directly among humans, without the interposition of fleas.Russia developed such a plague weapon.

It picked up genes directly from baculoviruses that infect insects, including one for a toxin that damages the midgut. It also acquired "pathogenicity islands", by assembling of genes from other bacteria that help cause human disease.

The sequence also reveals new surface molecules, which might provide new ways to attack plague. But "this genome displays unusual fluidity," comment Stewart Cole and Carmen Buchreiser in the magazine Nature, where the genome is published. Numerous Yersinia genes have been copie d backwards and have exchanged positions within the genome, sometimes creating different variants in the same population.

These recombinations could mean differences in virulence in a single batch of plague, they note. That could also mean that the bacteria - or bioweapons developers - have the genes at their disposal for new and potentially vexatious strains of disease.


'"/>




Related medicine news :

1. High -tech Mitochondrial DNA Sequencing Tool Updated
2. Plague creates panic in India
3. Tobacco plant based Vaccine against Plague
4. Mosquito Plague Reported From Western Australia
5. Health Services Plagued By Corruption
6. Bubonic Plague Confirmed In L.A. After More Than Two Decades
7. Crisis Of Bubonic Plague In New Mexico
8. Pneumonic Plague Kills 22 People in Congo
9. Plague Proteome Reveals Proteins Linked to Infection
10. Disabling Key Protein may Give Physicians Time to Treat Pneumonic Plague
11. Scientists Find Potential Weakness In Plague Germ
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate ... primary prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, ... lowdown on sciatica in a new episode of "Success Files," which is an ... and innovation and investigates each subject in-depth with passion and integrity. , Sciatica ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... introduction of an innovative new design of the shoulder pad. The shoulder pad ... comfort while controlling your pain while using cold therapy. By utilizing ice and water ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
Breaking Medicine Technology: