Navigation Links
Sequencing of the Plague

Bubonic plague, the bacterium blamed for the Black Death during middle ages in Europe and now a potential biological weapon, has had its entire genome sequenced. The genes seem to be "unusually fluid", readily re-arranging themselves and picking up new genes from other microbes. That could mean that more virulent strains of plague might emerge. More ominously, it suggests that enhanced strains might be relatively easy to develop as weapons.

The bacillus that causes bubonic plague, Yersinia pestis, commonly infects rodents in Asia, Africa and the Americas. But it occasionally spreads to humans, with fatal effect.It does so by infecting both insects and mammals. Fleas that feed on infected rodents swallow the bacteria, which infect and block their midguts. The starving fleas feed ravenously, but only regurgitate the blood they try to swallow - along with the bacteria. So plague spreads among rodents, often causing only mild disease.//

If the infected flea bites a human, however, up to half the victims die, unless treated with antibiotics. If the bacteria invade the lungs of such patients, and they cough them out, nearby people may catch "pneumonic" plague. This is always fatal without treatment.

Pneumonic plague is the form feared as a latent biological weapon, as it can be released as an aerosol and can spread directly among humans, without the interposition of fleas.Russia developed such a plague weapon.

It picked up genes directly from baculoviruses that infect insects, including one for a toxin that damages the midgut. It also acquired "pathogenicity islands", by assembling of genes from other bacteria that help cause human disease.

The sequence also reveals new surface molecules, which might provide new ways to attack plague. But "this genome displays unusual fluidity," comment Stewart Cole and Carmen Buchreiser in the magazine Nature, where the genome is published. Numerous Yersinia genes have been copie d backwards and have exchanged positions within the genome, sometimes creating different variants in the same population.

These recombinations could mean differences in virulence in a single batch of plague, they note. That could also mean that the bacteria - or bioweapons developers - have the genes at their disposal for new and potentially vexatious strains of disease.


'"/>




Related medicine news :

1. High -tech Mitochondrial DNA Sequencing Tool Updated
2. Plague creates panic in India
3. Tobacco plant based Vaccine against Plague
4. Mosquito Plague Reported From Western Australia
5. Health Services Plagued By Corruption
6. Bubonic Plague Confirmed In L.A. After More Than Two Decades
7. Crisis Of Bubonic Plague In New Mexico
8. Pneumonic Plague Kills 22 People in Congo
9. Plague Proteome Reveals Proteins Linked to Infection
10. Disabling Key Protein may Give Physicians Time to Treat Pneumonic Plague
11. Scientists Find Potential Weakness In Plague Germ
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... February 23, 2017 , ... ... , media relations, content marketing, social media management, corporate communications, SEO and cause ... the state and in nearby New Hampshire, Massachusetts and Canada, Rosica will focus ...
(Date:2/23/2017)... Colorado (PRWEB) , ... February 23, 2017 , ... ... Magazine, an exciting, new, interactive publication where generations converge and explore the world ... expand their worldview, Dialog Magazine enables readers to gain understanding, increase empathy, and ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... new partnership with the Rhode Island Consortium for Autism Research and Treatment (RI-CART) ... for children with autism spectrum disorder (ASD) to see films in an environment ...
(Date:2/23/2017)... ... 2017 , ... Curemark, LLC announced today that the Blüm Study, a Phase ... 3-8 with Autism, is now enrolling at three new sites. These new sites are ... , “There are currently no approved drugs that address the core symptoms of ...
(Date:2/22/2017)... York (PRWEB) , ... February 22, 2017 , ... ... entrance and lobby of a new healthcare contact center in Georgia, PENETRON Specialty ... One of the nation’s largest healthcare systems recently invested $51 million to purchase ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017  Cogentix Medical, Inc. ... and markets innovative proprietary products for the urology market, ... fiscal year ended December 31, 2016 before the market ... The Company will host a conference call and webcast ... Thursday, March 9, 2017 at 11:00 a.m. Eastern Time ...
(Date:2/23/2017)... Feb 23, 2017 Research and Markets has announced ... 2016" report to their offering. ... The latest research Menopause Drugs Price Analysis and Strategies - ... The research answers the following questions: ... How are they positioned in the Global Menopause market? ...
(Date:2/23/2017)... 23, 2017 Research and Markets has announced ... - 2016" report to their offering. ... The latest research Fibromyalgia Drugs Price ... in the global Fibromyalgia market. The research answers the ... marketed for Fibromyalgia and their clinical attributes? How are they positioned ...
Breaking Medicine Technology: