Navigation Links
Sentry Enzyme Blocks Two Paths to Parkinson’s Diseas

t of Developmental Neurobiology at St. Jude. “In the future, treatments that increase GST pi levels in the substantia nigra might help to prevent or delay the onset of Parkinson’s disease or reduce its severity,” said Smeyne, the report’s senior author.

GST pi is one of a family of similar enzymes that eliminate free radicals generated by pesticides and other chemicals. Two members of this family are present in the brain, but only one of them, GST pi, is found in the dopaminergic neurons of the substantia nigra. Free radicals are highly unstable molecules that readily interact with other molecules, causing cell damage.

The study sheds light on the cause of most cases of Parkinson’s disease, which currently are unexplained. “The majority of these cases of Parkinson’s disease appear to arise because individuals who have a genetic susceptibility to the disease are exposed to environmental toxins such as pesticides and herbicides, which trigger the formation of free radicals that kill dopaminergic neurons in the substantia nigra,” Smeyne said. “We also know that GST pi blocks the process of cell suicide triggered by stresses that the cell can’t overcome, such as an increase in the presence of free radicals or a loss of the cell’s ability to produce energy.”

Smeyne’s team showed that of the two known types of GST in the brain, only GST pi was present in the dopaminergic neurons that are lost in Parkinson’s disease. The scientists then treated two different populations of mice with MPTP, a chemical that causes loss of these cells, in order to determine if levels of GST pi changed. In mice known to be sensitive to MPTP, there was a complete but transient loss of GST pi in the dopaminergic neurons of the substantia nigra, while the same area of the brain in MPTP-resistant mice never completely lost GST pi and recovered their original levels within 12 hours.

In addition, the team showed that when MPTP-resistant mice were trea
'"/>




Page: 1 2 3 4

Related medicine news :

1. Enzyme may be target for obesity drugs
2. Researchers trick Alzheimers Enzyme
3. Enzyme stimulates growth of adult stem cells
4. Enzyme may aid hold back disease
5. Enzyme help destroy cancer cell
6. Enzyme Associated with Memory
7. Enzyme Associated With Memory
8. Brain Enzyme Found To Regulate Weight
9. New Enzyme Identified For Arthritis
10. Enzyme for treatment of arthritis
11. An Enzyme That Turns a One –time Experience into a long-time Memor
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sentry Enzyme Blocks Two Paths Parkinson Diseas

(Date:10/25/2014)... -- Researchers who discovered antibiotics in farmed and ... concern. The use of antibiotics in animals, ... contribute to the development of antibiotic-resistant bacteria that ... the study. Each year in the United ... and kill about 23,000, according to the Infectious ...
(Date:10/25/2014)... 2014 (HealthDay News) -- Current osteoporosis screening guidelines ... women at risk for osteoporosis-related fractures, a new ... fractures, we need tools that help us accurately ... that we can target these at-risk people for ... of medicine in the division of general internal ...
(Date:10/25/2014)... shorter, darker days can trigger a type of depression, ... People affected by seasonal affective disorder, also ... even have trouble getting out of bed. In extreme ... Halaris, a professor in the department of psychiatry and ... Medicine. "Seasonal affective disorder should not be taken ...
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville ... health and fitness fair ¡Vive tu vida! Get Up! Get ... nutrition for better health and wellness for people of all ... open to the public, will be held at Dean Porter ... to 1:00 pm. , “¡Vive tu Vida! Get Up! ...
(Date:10/22/2014)... 22, 2014 Medical Solutions ... is happy to announce that our co-founder and ... Industry Analysts’ Staffing 100 for 2014. Anderson was ... most influential people in the staffing industry,” in ... the 13th-largest healthcare staffing company in the U.S., ...
Breaking Medicine News(10 mins):Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3
... researchers at the Salk Institute for Biological Studies and ... suppressor p53, long thought of as the "Guardian of ... It may also prevent established cancer cells from sliding ... a "Guardian against Genome Reprogramming." The new work, ...
... study from the Swedish medical university Karolinska Institutet sheds ... brain of the first Alzheimer,s patient to display amyloids ... during progression of the disease and after death. ... accumulation in the brain of beta-amyloid proteins to form ...
... , MONDAY, Dec. 13 (HealthDay News) -- A federal ... is unconstitutional, saying the federal government has no authority to ... is a cornerstone of the new legislation, signed into law ... was not unexpected, and both supporters and opponents of the ...
... recognized that fragmentation of medical information is a problem in ... many patients may be at risk haven,t been well quantified. ... looked at adult acute care in Massachusetts and found that ... a five-year period, almost a third sought care at two ...
... devastating side effect of chemotherapy with an innovative new program ... reduce scalp hair loss in breast cancer patients. One ... inquiry of its kind in the United States, will test ... overseas called the "DigniCap." The FDA recently approved a pilot ...
... 13 (HealthDay News) -- About 40 percent of patients ... to conventional treatments, finds a new study. German ... grade IV gliomas (tumors) about their use of alternative ... percent used homeopathy, 31 percent used vitamin supplements and ...
Cached Medicine News:Health News:The stemness of cancer cells 2Health News:The stemness of cancer cells 3Health News:Unique case study on Alzheimer's disease 2Health News:Federal Judge Strikes Down Health Reform Law 2Health News:Federal Judge Strikes Down Health Reform Law 3Health News:Quantifying fragmentation of medical information 2Health News:Quantifying fragmentation of medical information 3Health News:UCSF tests promising solutions for cancer hair loss 2Health News:UCSF tests promising solutions for cancer hair loss 3Health News:Many Brain Tumor Patients Turn to Alternative Therapies 2
(Date:10/25/2014)... , Oct. 24, 2014 Research and ... Equipment Market Current Trends, Opportunities - Global Forecast to ... In this report, the global dental equipment market is ... dental systems and equipment market is expected to register ... during the forecast period (2014 to 2019). This high ...
(Date:10/25/2014)... 24, 2014  The National Association of Drug ... achieved by Kentucky,s real-time, ... The National Precursor Log Exchange (NPLEx) system automatically ... sale and helps flag meth offenders for law ... up NPLEx "watch lists" that notify them via ...
(Date:10/25/2014)... 2014 Burzynski Research Institute, Inc. (BRI) announced ... has given the company permission to conduct an open-label ... 3 months of age with a diffuse intrinsic brainstem ... of five treatment groups based on their age and ... DIPG. The primary study endpoint is a decrease in ...
Breaking Medicine Technology:Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 2Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 3Kentucky's NPLEx Technology Making Significant Progress 2Burzynski Research Institute, Inc. Announces FDA Permission to Launch a New Clinical Trial in Diffuse Intrinsic Brainstem Glioma 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: