Navigation Links
Sensible Diet, Exercise and Weight Control Increases Longevity

A new research has shown just how a sensible diet, exercise and weight control helps people live a longer life.

Researchers from Howard Hughes Medical Institute have found that all these factors increase longevity by reducing signalling through a specific pathway in the brain.

This insulin-like pathway governs growth and metabolic processes in cells throughout the body. The pathway is activated when insulin and insulin-like growth factor-1 switch on proteins inside the cell called insulin receptor substrates (Irs).

Other researchers have already shown that reducing the activity of the pathway in roundworms and fruitflies extends lifespan.

Because reducing insulin-like signalling in the neurons of roundworms and fruitflies extends their lifespan, the researchers decided to examine what would happen when they knocked out one or both copies of the Irs2 gene only in the brains of mice.

Mice lacking one copy of the Irs2 gene in brain cells also showed an 18 percent longer lifespan, and the near complete deletion of brain Irs2 had a similar effect.

Lead author Morris F. White said that the finding had come as a bit of a shock for the researchers.

The idea that insulin reduces lifespan is difficult to reconcile with decades of clinical practice and scientific investigation to treat diabetes, he said.

In fact, based on our work on one of the insulin receptor substrates, Irs2, in liver and pancreatic beta cells, we thought more Irs2 would be good for you.

It reduces the amount of insulin needed in the body to control blood glucose, and it promotes growth, survival and insulin secretion from pancreatic beta cells, he added.

In earlier work, the researchers had found that knocking out both copies of the Irs2 gene in mice reduces brain growth and produces diabetes due to pancreatic beta cell failure. However, in the new study, when the re searchers knocked out only one copy of the gene, they found the mice lived 18 percent longer than normal mice.

Whats more, the animals lived longer, even though they had characteristics that should shorten their livessuch as being overweight and having higher insulin levels in the blood, said White.

However, both sets of Irs2 knockout mice exhibited other characteristics that marked them as healthier. They were more active as they aged, and their glucose metabolism resembled that of younger mice.

The researchers also found that after eating, their brains showed higher levels of superoxide dismutase, an antioxidant enzyme that protects cells from damage by highly reactive chemicals called free radicals.

Our findings put a mechanism behind what your mother told when you were growing upeat a good diet and exercise, and it will keep you healthy, said White.

Diet, exercise and lower weight keep your peripheral tissues sensitive to insulin. That reduces the amount and duration of insulin secretion needed to keep your glucose under control when you eat. Therefore, the brain is exposed to less insulin. Since insulin turns on Irs2 in the brain, that means lower Irs2 activity, which weve linked to longer lifespan in the mouse.

The study was co-authored by Akiko Taguchi and Lynn Wartschow in Whites laboratory in the Division of Endocrinology at Childrens Hospital Boston and Harvard Medical School.

White speculated that the insulin-like signaling pathway in the brain might promote age-related brain diseases.

We are beginning to appreciate that obesity, insulin resistance, and high blood insulin levels are connected to Alzheimers disease, Huntingtons disease, and dementias in general, he said.

It might be that, in people who are genetically predisposed to these diseases, too much insulin overactivates Irs2 in the brain and accelerates disease pro gression. Thus, insulin resistance and higher insulin levels might be the environmental influences that promote these diseases, he said.


Related medicine news :

1. Sensible drinking staves off strokes
2. Sensible Overall Dietary Pattern More Important than Individual Food Choices
3. Sensible Diet and Good Exercise is the Key to Lose Weight
4. Diet, Sunlight connected to Breast Cancer Risk
5. Healthy Diet, Exercise can Halve the Risk of Mortality in Breast Cancer Survivors
6. Exercises reduce risks of cancers
7. Exercise lowers Risk of Ovarian Cancer
8. Exercise is necessary in daily life
9. Exercise for patients with cancer
10. Exercise therapy for fibromyalgia
11. Exercise has a undeniable effect on cholesterol
Post Your Comments:

(Date:11/25/2015)... ... November 25, 2015 , ... Beddit® has launched a new Android app ... new app features a more intuitive SleepScore™ that rates sleep quality on a 100-point ... SleepScore is created by a proprietary algorithm. Beddit analyzes the data to provide an ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical ... Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of its product ... intensive care units (totaling 30 beds) from May 2014 through October 2015 at a ...
(Date:11/25/2015)... ... , ... Today, Mothers Against Drunk Driving (MADD) learned that the ... the first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol ... National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in ...
(Date:11/25/2015)... ... November 25, 2015 , ... In ... nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for pulmonary hypertension ... Pioneers, nominated by the public, will receive special recognition throughout 2016 as part ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately owned Contract Development ... expansion of its current state of the art research, development and manufacturing facility ... increase its manufacturing capacity as well as to support its clients’ growing research ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, ... optimizing treatment outcomes for patients suffering from chronic pain, ... for a Temporary Restraining Order (TRO) enjoining Express Scripts ... two companies. --> --> ... all of its legal options. --> ...
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (NASDAQ: KTOV ) (TASE: KTOV), a biopharmaceutical company ... simultaneous treatment of various clinical conditions, today announced the ... 3,158,900 American Depository Shares ( ADSs ), each representing ... purchase up to 3,158,900 ADSs. The ADSs and warrants ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 Endo International ... Rajiv De Silva , President and CEO, will discuss ... Healthcare Conference in New York on ... . Click on Investor Relations, and then the ... prior to the presentation,s start time to visit the site ...
Breaking Medicine Technology: