Navigation Links
Sensible Diet, Exercise and Weight Control Increases Longevity

A new research has shown just how a sensible diet, exercise and weight control helps people live a longer life.

Researchers from Howard Hughes Medical Institute have found that all these factors increase longevity by reducing signalling through a specific pathway in the brain.

This insulin-like pathway governs growth and metabolic processes in cells throughout the body. The pathway is activated when insulin and insulin-like growth factor-1 switch on proteins inside the cell called insulin receptor substrates (Irs).

Other researchers have already shown that reducing the activity of the pathway in roundworms and fruitflies extends lifespan.

Because reducing insulin-like signalling in the neurons of roundworms and fruitflies extends their lifespan, the researchers decided to examine what would happen when they knocked out one or both copies of the Irs2 gene only in the brains of mice.

Mice lacking one copy of the Irs2 gene in brain cells also showed an 18 percent longer lifespan, and the near complete deletion of brain Irs2 had a similar effect.

Lead author Morris F. White said that the finding had come as a bit of a shock for the researchers.

The idea that insulin reduces lifespan is difficult to reconcile with decades of clinical practice and scientific investigation to treat diabetes, he said.

In fact, based on our work on one of the insulin receptor substrates, Irs2, in liver and pancreatic beta cells, we thought more Irs2 would be good for you.

It reduces the amount of insulin needed in the body to control blood glucose, and it promotes growth, survival and insulin secretion from pancreatic beta cells, he added.

In earlier work, the researchers had found that knocking out both copies of the Irs2 gene in mice reduces brain growth and produces diabetes due to pancreatic beta cell failure. However, in the new study, when the re searchers knocked out only one copy of the gene, they found the mice lived 18 percent longer than normal mice.

Whats more, the animals lived longer, even though they had characteristics that should shorten their livessuch as being overweight and having higher insulin levels in the blood, said White.

However, both sets of Irs2 knockout mice exhibited other characteristics that marked them as healthier. They were more active as they aged, and their glucose metabolism resembled that of younger mice.

The researchers also found that after eating, their brains showed higher levels of superoxide dismutase, an antioxidant enzyme that protects cells from damage by highly reactive chemicals called free radicals.

Our findings put a mechanism behind what your mother told when you were growing upeat a good diet and exercise, and it will keep you healthy, said White.

Diet, exercise and lower weight keep your peripheral tissues sensitive to insulin. That reduces the amount and duration of insulin secretion needed to keep your glucose under control when you eat. Therefore, the brain is exposed to less insulin. Since insulin turns on Irs2 in the brain, that means lower Irs2 activity, which weve linked to longer lifespan in the mouse.

The study was co-authored by Akiko Taguchi and Lynn Wartschow in Whites laboratory in the Division of Endocrinology at Childrens Hospital Boston and Harvard Medical School.

White speculated that the insulin-like signaling pathway in the brain might promote age-related brain diseases.

We are beginning to appreciate that obesity, insulin resistance, and high blood insulin levels are connected to Alzheimers disease, Huntingtons disease, and dementias in general, he said.

It might be that, in people who are genetically predisposed to these diseases, too much insulin overactivates Irs2 in the brain and accelerates disease pro gression. Thus, insulin resistance and higher insulin levels might be the environmental influences that promote these diseases, he said.


'"/>




Related medicine news :

1. Sensible drinking staves off strokes
2. Sensible Overall Dietary Pattern More Important than Individual Food Choices
3. Sensible Diet and Good Exercise is the Key to Lose Weight
4. Diet, Sunlight connected to Breast Cancer Risk
5. Healthy Diet, Exercise can Halve the Risk of Mortality in Breast Cancer Survivors
6. Exercises reduce risks of cancers
7. Exercise lowers Risk of Ovarian Cancer
8. Exercise is necessary in daily life
9. Exercise for patients with cancer
10. Exercise therapy for fibromyalgia
11. Exercise has a undeniable effect on cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: